Bertrand Castaing

Documents

Publications

	Identification of key residues of the DNA glycosylase OGG1 controlling efficient DNA sampling and recruitment to oxidized bases in living cells Ostiane d'Augustin , Virginie Gaudon , Capucine Siberchicot , Rebecca Smith , Catherine Chapuis Nucleic Acids Research, 2023, 51 (10), pp.4942-4958. ⟨10.1093/nar/gkad243⟩ Article dans une revue hal-04088267v2
	OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression Xhaferr Tanushi , Guillaume Pinna , Marie Vandamme , Capucine Siberchicot , Ostiane D’augustin Frontiers in Cell and Developmental Biology, 2023, 11, pp.1124960. ⟨10.3389/fcell.2023.1124960⟩ Article dans une revue hal-04016264v1
	Structure-dependent recruitment and diffusion of guest proteins in liquid droplets of FUS Kiyoto Kamagata , Nanako Iwaki , Saori Kanbayashi , Trishit Banerjee , Rika Chiba Scientific Reports, 2022, 12 (1), pp.7101. ⟨10.1038/s41598-022-11177-w⟩ Article dans une revue hal-03927893v1
	Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing Coste Franck , Stéphane Goffinont , Julien Cros , Virginie Gaudon , Guérin Martine Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac932⟩ Article dans une revue hal-03841526v1
	Molecular principles of recruitment and dynamics of guest proteins in liquid droplets Kiyoto Kamagata , Nanako Iwaki , Milan Kumar Hazra , Saori Kanbayashi , Trishit Banerjee Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-98955-0⟩ Article dans une revue hal-03433608v1
	Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1 Alan Wacquiez , Franck Coste , Emmanuel Kut , Virginie Gaudon , Sascha Trapp Viruses, 2020, 12 (9), 25 p. ⟨10.3390/v12090947⟩ Article dans une revue hal-03082436v1
	Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights Charlotte Rieux , Stéphane Goffinont , Franck Coste , Zahira Tber , Julien Cros International Journal of Molecular Sciences, 2020, 21 (6), pp.2058. ⟨10.3390/ijms21062058⟩ Article dans une revue hal-03082414v1
	New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure Karine Loth , Justine Largillière , Franck Coste , Françoise Culard , Céline Landon Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-50211-2⟩ Article dans une revue hal-02306224v1
	Microwave-assisted Suzuki-Miyaura and Sonogashira coupling of 4-Chloro-2-(trifluoromethyl)pyrido[1,2-e]purine derivatives Zahira Tber , Nicolas G. Biteau , Luigi Agrofoglio , Julien Cros , Stéphane Goffinont European Journal of Organic Chemistry, 2019, 2019, pp.5756-5767. ⟨10.1002/ejoc.201900921⟩ Article dans une revue hal-02347523v1
	Liquid Native MALDI Mass Spectrometry for the Detection of Protein-Protein Complexes Martine Beaufour , David Ginguené , Rémy Le Meur , Bertrand Castaing , Martine Cadène Journal of The American Society for Mass Spectrometry, 2018, 29 (10), pp.1981-1994. ⟨10.1007/s13361-018-2015-x⟩ Article dans une revue hal-01965971v1
	Repair of 8-oxo-7,8-dihydroguanine in prokaryotic and eukaryotic cells: Properties and biological roles of the Fpg and OGG1 DNA N -glycosylases Serge Boiteux , Franck Coste , Bertrand Castaing Free Radical Biology and Medicine, 2017, 107, pp.179 - 201. ⟨10.1016/j.freeradbiomed.2016.11.042⟩ Article dans une revue hal-01618166v1
	The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase R. Le Meur , Françoise Culard , V. Nadan , S. Goffinont , F. Coste Biochemical Journal, 2015, 471 (1), pp.13-23. ⟨10.1042/BJ20150387⟩ Article dans une revue hal-01216639v1
	ATP-dependent motor activity of the transcription termination factor Rho from Mycobacterium tuberculosis F. d'Heygere , A. Schwartz , F. Coste , B. Castaing , M. Boudvillain Nucleic Acids Research, 2015, 43 (12), pp.6099-60111. ⟨10.1093/nar/gkv505⟩ Article dans une revue hal-01171219v1
	Backbone assignment of the three dimers of HU from Escherichia coli at 293 K: EcHUα2, EcHUβ2 and EcHUαβ Rémy Le Meur , Karine Loth , Françoise Culard , Bertrand Castaing , Céline Landon Biomolecular NMR Assignments, 2015, 9 (2), pp.359-363. ⟨10.1007/s12104-015-9610-6⟩ Article dans une revue hal-01171467v1
	Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea Françoise Paquet , Olivier Delalande , Stephane Goffinont , Françoise Culard , Karine Loth PLoS ONE, 2014, 9 (2), pp.e88809. ⟨10.1371/journal.pone.0088809⟩ Article dans une revue hal-01063974v1
	Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization A. Biela , F. Coste , F. Culard , M. Guerin , S. Goffinont Nucleic Acids Research, 2014, 42 (16), pp.doi: 10.1093/nar/gku613. ⟨10.1093/nar/gku613⟩ Article dans une revue hal-01175522v1
	The orientation of the C-terminal domain of the Saccharomyces cerevisiae Rap1 protein is determined by its binding to DNA Béatrice Matot , Yann-Vaï Le Bihan , Rachel Lescasse , Javier Pérez , Simona Miron Nucleic Acids Research, 2012, 40 (7), pp.3197-207. ⟨10.1093/nar/gkr1166⟩ Article dans une revue hal-00720647v1
	Binding of the RamR repressor to wild-type and mutated promoters of the RamA gene involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. Sylvie Baucheron , Franck Coste , Sylvie Canepa , Marie-Christine Maurel , Etienne Giraud Antimicrobial Agents and Chemotherapy, 2012, 56 (2), pp.942-8. ⟨10.1128/AAC.05444-11⟩ Article dans une revue hal-00721770v1
	5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases Yann Vei Le Bihan , Angeles M. Izquierdo , Franck Coste , Pierre Aller , Françoise Culard Nucleic Acids Research, 2011, 39 (14), pp.6277-6290. ⟨10.1093/nar/gkr215⟩ Article dans une revue hal-00614943v1
	An alternative flexible conformation of the E. coli HU beta(2) protein: structural, dynamics, and functional aspects Norbert Garnier , Karine Loth , Franck Coste , Rafal Augustyniak , Virginie Nadan European Biophysics Journal, 2011, 40 (2), pp.117-129. ⟨10.1007/s00249-010-0630-y⟩ Article dans une revue hal-00602370v1
	Scaling of ac electrical conductivity of powders under compression Mathieu Creyssels , Éric Falcon , Bertrand Castaing Physical Review B: Condensed Matter and Materials Physics (1998-2015), 2008, 77 (7), pp.075135. ⟨10.1103/PhysRevB.77.075135⟩ Article dans une revue hal-00264434v1
	Complex oligomeric structure of a truncated form of DdrA: A protein required for the extreme radiotolerance of Deinococcus. Irina Gutsche , Andreja Vujicić-Zagar , Xavier Siebert , Pascale Servant , Françoise Vannier Biochimica et Biophysica Acta - Molecular Cell Research, 2008, 1784 (7-8), pp.1050-8. ⟨10.1016/j.bbapap.2008.03.009⟩ Article dans une revue hal-00297143v1
	Bacterial base excision repair enzyme Fpg recognizes bulky N7-substituted-FapydG lesion via unproductive binding mode. Franck Coste , Matthias Ober , Yann-Vaï Le Bihan , Maria Angeles Izquierdo , Nadège Hervouet Chemistry & Biology / Chemistry and Biology; CHEMISTRY & BIOLOGY, 2008, 15 (7), pp.706-17. ⟨10.1016/j.chembiol.2008.05.014⟩ Article dans une revue hal-00408047v1
	Some aspects of electrical conduction in granular systems of various dimensions Mathieu Creyssels , Stéphane Dorbolo , Alexandre Merlen , Claude Laroche , Bertrand Castaing European Physical Journal E: Soft matter and biological physics, 2007, 23, pp.255. ⟨10.1140/epje/i2006-10186-9⟩ Article dans une revue hal-00170319v3
	Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by Formamidopyrimidine-DNA glycosylase F. Coste , M. Ober , T. Carrell , S. Boiteux , C. Zelwer Journal of Biological Chemistry, 2006, 279 (42), pp.44074-44083. ⟨10.1074/jbc.M405928200⟩ Article dans une revue hal-00114389v1
	Location and base selectivity on fragmentation of brominated oligodeoxynucleotides C. Buré , B. Castaing , C. Lange , A.F. Delmas Journal of Mass Spectrometry, 2006, 41 (1), pp.84-90. ⟨10.1002/jms.967⟩ Article dans une revue hal-00088837v1
	Modification of DNA radiolysis by DNA-binding proteins: structural aspects Marie Davídková , Viktorie Stísová , Stéphane Goffinont , Nathalie Gillard , Bertrand Castaing Radiation Protection Dosimetry, 2006, 122 (1-4), pp.100-105. ⟨10.1093/rpd/ncl442⟩ Article dans une revue hal-00168743v1
	BER: (Base excision repair): molecular mechanisms and biological roles Stéphane Boiteux , Bertrand Castaing , J.P. Radicella Biofutur, 2006, 25 (271), pp.35-39 Article dans une revue hal-00387927v1
	Radiolysis of DNA-protein complexes M. Bégusovà , N. Gillard , D. Sy , B. Castaing , M. Charlier Radiation Physics and Chemistry, 2005, 72, pp.265-270 Article dans une revue hal-00088505v1
	Structural insights into abasic site for Fpg specific binding and catalysis: comparative high-resolution crystallographic studies of Fpg bound to various models of abasic site analogues containing DNA K. Pereira de Jesus , L. Serre , C. Zelwer , B. Castaing Nucleic Acids Research, 2005, 33, pp.5936-5944 Article dans une revue hal-00088666v1
	Insights into the DNA repair process by the formamidopyrimidine-DNA glycosylase investigated by molecular dynamics Patricia Amara , Laurence Serre , B. Castaing , A. Thomas Journal of Biological Chemistry, 2004, 13 (8), pp.2009-2021. ⟨10.1110/ps.04772404⟩ Article dans une revue hal-00088335v1
	Radiation affects binding of Fpg repair protein to an abasic site containing DNA N. Gillard , M. Bégusovà , B. Castaing , M. Spotheim-Maurizot Radiation Research, 2004, 162, pp.566-571. ⟨10.1667/RR3247⟩ Article dans une revue hal-00113044v1
	Recognition of cyclonucleoside lesions by the Lactococcus lactis FPG protein E. Muller , D. Gasparutto , B. Castaing , A. Favier , J. Cadet Nucleosides, Nucleotides and Nucleic Acids, 2003, 22, pp.1563-1565 Article dans une revue hal-00088198v1
	Evidence of a thermal unfolding dimeric intermediate for the Escherichia coli histone-like HU proteins: thermodynamics and structure. Charles Ramstein , Nadège Hervouet , Franck Coste , Charles Zelwer , Jacques Oberto Journal of Molecular Biology, 2003, 331 (1), pp.101-21 Article dans une revue hal-02127656v1
	Crystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA Laurence Serre , Karine Pereira de Jésus , Serge Boiteux , Charles Zelwer , Bertrand Castaing EMBO Journal, 2002, 21 (12), pp.2854-2865. ⟨10.1093/emboj/cdf304⟩ Article dans une revue hal-02141118v1
	Crystallization and preliminary X-ray crystallographic studies of a complex between the Lactococcus lactis Fpg DNA-repair enzyme and an abasic site containing DNA Karine Pereira de Jésus , Laurence Serre , Nadège Hervouet , Véronique Bouckson-Castaing , Charles Zelwer Acta crystallographica Section D : Structural biology [1993-..], 2002, 58 (4), pp.679-682. ⟨10.1107/S0907444902001397⟩ Article dans une revue hal-02141124v1
	Catalytic and DNA binding properties of the ogg1 protein of Saccharomyces cerevisiae: comparison between the wild type and the K241R and K241Q active-site mutant proteins. N Guibourt , Bertrand Castaing , P van Der Kemp , S. Boiteux Biochemistry, 2000, 39 (7), pp.1716-24 Article dans une revue hal-02141126v1
	AP site structural determinants for Fpg specific recognition Bertrand Castaing , Jean-Louis Fourrey , Nadege Hervouet-Coste , Martial Thomas , Serge Boiteux Nucleic Acids Research, 1999, 27 (2), pp.608-615. ⟨10.1093/nar/27.2.608⟩ Article dans une revue hal-02141144v1
	Crystallization and preliminary X-ray diffraction analysis of the homodimeric form alpha2 of the HU protein from Escherichia coli. Franck Coste , N. Hervouet , J. Oberto , C. Zelwer , Bertrand Castaing Acta crystallographica Section D : Structural biology [1993-..], 1999, 55 (Pt 11), pp.1952-4 Article dans une revue hal-02127644v1
	Synthesis of an Enantiomerically Pure Carbocyclic DNA Abasic Site Analogue Martial Thomas , Bertrand Castaing , Jean-Louis Fourrey , Charles Zelwer Nucleosides and Nucleotides, 1999, 18 (2), pp.239-243. ⟨10.1080/15257779908043071⟩ Article dans une revue hal-02141150v1
	HU Protein of Escherichia coli Binds Specifically to DNA That Contains Single-strand Breaks or Gaps Bertrand Castaing , Charles Zelwer , Jacques Laval , Serge Boiteux Journal of Biological Chemistry, 1995, 270 (17), pp.10291-10296. ⟨10.1074/jbc.270.17.10291⟩ Article dans une revue hal-02141159v1
	Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role. T.R O'Connor , R.J Graves , G. de Murcia , Bertrand Castaing , J Laval Journal of Biological Chemistry, 1993, 268 (12), pp.9063-70 Article dans une revue hal-02141187v1
	Cleavage and binding of a DNA fragment containing a single 8-oxoguanine by wild type and mutant FPG proteins Bertrand Castaing , Albert Geiger , Hartmut Seliger , Peter Nehls , Jacques Laval Nucleic Acids Research, 1993, 21 (12), pp.2899-2905. ⟨10.1093/nar/21.12.2899⟩ Article dans une revue hal-02141167v1
	DNA containing a chemically reduced apurinic site is a high affinity ligand for the E.coli formamidopyrimidine-DNA glycosyiase Bertrand Castaing , Serge Boiteux , Charles Zelwer Nucleic Acids Research, 1992, 20 (3), pp.389-394. ⟨10.1093/nar/20.3.389⟩ Article dans une revue hal-02141191v1
	Purification and characterization of the Saccharomyces cerevisiae mitochondrial leucyl-tRNA synthetase. W Zagorski , Bertrand Castaing , C.J Herbert , M Labouesse , R Martin Journal of Biological Chemistry, 1991, 266 (4), pp.2537-41 Article dans une revue hal-02141199v1

	Architecture et dynamique de protéines histone-like de bactérie et d’archées Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon Journée BioRMN IdF, Sep 2020, Gif-sur-Yvette, France Communication dans un congrès hal-03053296v1
	Inhibition des ADN glycosylases de la super famille structurale Fpg/Nei par des thiopurines: relations structure-activité Bertrand Castaing Journée scientifique de la Fédération de Recherche 2708, Apr 2019, Orléans, France Communication dans un congrès hal-02903112v1
	Vers une description cinétique et structurale complète du mécanisme d'échange de chaînes de la protéine HU d'Escherichia coli. Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon XXXIe congrès du GERM (Groupement d'Etudes de Résonance Magnétique), May 2019, Oléron, France Communication dans un congrès hal-02361645v1
	Les ADN glycosylases qui initient le système de réparation de l'ADN par excision de base, de nouvelles cibles potentielles pour lutter contre le cancer Bertrand Castaing Colloque du Réseau « Molécules marines, métabolisme et cancer » du Canréropôle Grand Ouest, May 2019, Mansigné, France Communication dans un congrès hal-02903074v1
	Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy J. Cros , F. Coste , S. Goffinont , Virginie Nadan , V. Roy Laboratoire International Associé, Jun 2019, Varsovie, Poland Communication dans un congrès hal-02903108v1
	Small molecule inhibitors of the human DNA glycosylases hOGG1 and NEIL1, pertinent therapeutic targets in cancer and neurodegenerative disease therapies J. Cros , F. Coste , Z. Tber , S. Goffinont , Virginie Nadan 25th Young Research Fellows Meeting, Mar 2018, Orléans, France Communication dans un congrès hal-02903084v1
	Des cristaux pour la recherche de nouveaux antiviraux Daniel Marc , Franck Coste , Bertrand Castaing Journées d'Animation Scientifique de la Fédération de Recherche d'Infectiologie (FéRI), Oct 2015, Orléans, France. 17 diapositives Communication dans un congrès hal-02792217v1

	Screening, characterization and structural studies of small molecules inhibitors of the DNA glycosylase hNEIL1 and hOGG1, potential therapeutic targets in cancer and neurodegenerative disease Julien Cros , Franck Coste , Stéphane Goffinont , Virginie Nadan , Norbert Garnier 1st French congress on Integrative Structural Biology (BSI-2019), Oct 2019, Toulouse, France Poster de conférence hal-03385201v1
	To a complete kinetics and structural description of the EcHU chain exchange system Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon NMR : a tool for biology XITh, Jan 2019, Paris, France Poster de conférence hal-02362588v1
	Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer J. Cros , F. Coste , S. Goffinont , V. Gaudon , V. Roy 13th French 3R meeting, May 2019, Presqu’île de Giens, France Poster de conférence hal-02903219v1
	Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer J. Cros , F. Coste , S. Goffinont , V. Gaudon , V. Roy Journée Fédération de recherche “Physique et Chimie du Vivant” FR2708 (CBM/ICOA), Apr 2019, Orléans, France Poster de conférence hal-02903223v1
	Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity F. Coste , G. Chaume , J.-B. Madinier , I. Rahioui , B. Castaing 21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France Poster de conférence hal-02893471v1
	To a complete kinetics and structural description of the EcHU chain exchange system. Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon Journée Fédération de recherche “Physique et Chimie du Vivant”, Apr 2019, Orléans, France Poster de conférence hal-02362578v1
	Interaction de la protéine NS1 des virus influenza A avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique Daniel Marc , Alan Wacquiez , Stéphane Goffinont , Virginie Nadan , Franck Coste XIIes Journées Francophones de Virologie, Mar 2019, Lyon, France. Virologie, 23, 2019 Poster de conférence hal-02737761v1
	Native and Intermediate conformations of the three HU dimers of E.coli. Justine Largillière , Rémy Le Meur , Norbert Garnier , Celine Landon , A.F. Delmas 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland Poster de conférence hal-02362585v1
	Recherche d’inhibiteurs des enzymes de réparation de l’ADN hNeil1 et hOGG1, de nouvelles cibles pertinentes pour le développement de thérapies anticancéreuses J. Cros , F. Coste , S. Goffinont , V. Gaudon , V. Roy 31e colloque Biotechnocentre, Oct 2018, Seillac, France Poster de conférence hal-02904682v1
	NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales Alan Wacquiez , Franck Coste , Caroline Blondeau , Emmanuel Kut , Virginie Nadan 20. Journées Francophones de Virologie 2018, Mar 2018, Paris, France. John Libbey Eurotext, Virologie, 22, 148 p., 2018 Poster de conférence hal-02736544v1
	Search for small molecule inhibitors of DNA glycosylases, pertinent therapeutic targets in cancer and neurodegenerative disease therapies J. Cros , F. Coste , Z. Tber , S. Goffinont , V. Nadan 5e Colloque annuel du Laboratoire International Associé (LIA) MiR-TANGo, May 2018, Orléans, France Poster de conférence hal-02904701v1
	New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure. Karine Loth , Justine Largillière , Franck Coste , Françoise Culard , Celine Landon EuroMar 2018, Jul 2018, Nantes, France Poster de conférence hal-02362581v1
	First kinetics description of the EcHU chain exchange system. Justine Largillière , Rémy Le Meur , David Ginguené , Celine Landon , A.F. Delmas 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland Poster de conférence hal-02362586v1
	To a complete kinetics and structural description of the EcHU chain exchange system. Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon 31e colloque Biotechnocentre, Oct 2018, Seillac, France Poster de conférence hal-02362818v1
	Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity F. Coste , G. Chaume , J.-B. Madinier , I. Rahioui , B. Castaing 35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland Poster de conférence hal-02894161v1
	Premières études cinétiques du mécanisme d’échange de chaînes de la protéine HU d’Escherischia coli. Justine Largillière , Rémy Le Meur , Martine Cadene , Bertrand Castaing , Karine Loth 16e colloque scientifique de l’ADOC : Converger pour Renforcer, Apr 2018, Orléans, France Poster de conférence hal-02362579v1
	Premières études cinétiques du mécanisme d’échange de chaînes de la protéine HU d’Escherischia coli. Justine Largillière , Rémy Le Meur , Martine Cadene , Bertrand Castaing , Karine Loth Journée Fédération de recherche “Physique et Chimie du Vivant”, Jan 2018, Orléans, France Poster de conférence hal-02362577v1
	New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure. Karine Loth , Françoise Culard , Justine Largillière , Celine Landon , Bertrand Castaing 5e séminaire scientifique du LIA MiR-TANGo, May 2018, Orléans, France Poster de conférence hal-02362804v1
	Structures et fonctions de la protéine NS1 des virus influenza pour la recherche de nouvelles cibles thérapeutiques Alan Wacquiez , Stéphane Goffinont , Virginie Nadan , Franck Coste , Emmanuel Kut 31e Colloque Biotechnocentre, Oct 2018, Seillac, France. , 2018 Poster de conférence hal-02736195v1
	New protein-DNA complexes in archaea: a small monomeric protein induces a V-turn structure. Karine Loth , Justine Largillière , Franck Coste , Françoise Culard , Bertrand Castaing 28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland Poster de conférence hal-02362584v1
	NS1 des virus influenza : relations structure-fonction pour la recherche de nouveaux anti-viraux A. Wacquiez , S. Goffinont , V. Nadan , F. Coste , E. Kut 30e colloque Biotechnocentre, Oct 2017, Seillac, France Poster de conférence hal-02904785v1
	New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure. Karine Loth , Justine Largillière , Franck Coste , A.F. Delmas , Bertrand Castaing Le Studium Confenrence: Structural biology and biophysics of RNA-protein complexes, Nov 2017, Orléans, France Poster de conférence hal-02362576v1
	NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales A. Wacquiez , F. Coste , C. Blondeau , E. Kut , V. Nadan Le Studium Conférence « Messenger RNA therapeutics : advances and perspectives », Mar 2017, Orléans, France Poster de conférence hal-02904828v1
	NS1 of Influenza viruses: structural and functional approaches towards the discovery of novel anti-influenza drugs A. Wacquiez , F. Coste , V. Nadan , E. Kut , S. Goffinont Le Studium Conférence “Structural Biology and biophysics of RNA-protein complexes”, Nov 2017, Orléans, France Poster de conférence hal-02904778v1
	Première description cinétique du mécanisme d’échange de chaînes de la protéine HU d'Escherichia coli. Justine Largillière , Rémy Le Meur , Martine Cadene , Bertrand Castaing , Karine Loth 30e colloque Biotechnocentre, Oct 2017, Seillac, France Poster de conférence hal-02361632v1
	The MC1-DNA complex solution structure reveals that a monomeric protein can induce a U-turn in archaea. Karine Loth , Françoise Culard , Justine Largillière , Celine Landon , Bertrand Castaing NMR: a tool for biology XTh, Jan 2017, Paris, France Poster de conférence hal-02361613v1
	Small-molecule inhibitors of Fpg/Nei DNA glycosylases, enzymes initiating the base excision repair pathway, new targets for cancer therapy C. Rieux , F. Coste , F. Culard , S. Goffinont , S. Bourg XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Jul 2016, Paris, France Poster de conférence hal-02919151v1
	Improvement of the chemical production of β-defensins including straightforward attribution of disulfide bridges Mathieu Galibert , Chrystelle Derache , Franck Coste , Hervé Meudal , Anne-Christine Lalmanach 18. Réunion du GFPP, May 2013, Sète, France. 1 p., 2013 Poster de conférence hal-02805308v1

	Ogg1, a Saccharomyces cerevisiae bifunctional DNA glycosylase involved in base excision repair of oxidative DNA damage, interacts with the replicative DNA polymerase, Pol epsilon Kadija Essalhi , L. Gellon , Julie Berthault , Françoise Culard , Martine Guerin pp.409, 2011 Ouvrages hal-00614891v1

	Monitoring RNA Unwinding by the Transcription Termination Factor Rho from Mycobacterium tuberculosis F. d'Heygère , A. Schwartz , F. Coste , B. Castaing , M. Boudvillain Methods in Mecular Biology, 1259, Springer, pp.293-311, 2015, RNA remodelling proteins (Boudvillain, ed), 978-1-4939-2213-0. ⟨10.1007/978-1-4939-2214-7_18⟩ Chapitre d'ouvrage hal-01174055v1
	Radiation damage to biomolecules, radioprotection and radiotherapy. Genome maintenance mechanisms in response to radiation-induced DNA damage Evelyne Sage , Bertrand Castaing Mélanie Spotheim-Maurizot. Radiation chemistry from basics to applications in material and life sciences, EDP Sciences, pp.219-232, 2008 Chapitre d'ouvrage hal-00284342v1

Bertrand Castaing

Publications

Identification of key residues of the DNA glycosylase OGG1 controlling efficient DNA sampling and recruitment to oxidized bases in living cells

OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression

Structure-dependent recruitment and diffusion of guest proteins in liquid droplets of FUS

Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing

Molecular principles of recruitment and dynamics of guest proteins in liquid droplets

Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1

Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights

New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure

Microwave-assisted Suzuki-Miyaura and Sonogashira coupling of 4-Chloro-2-(trifluoromethyl)pyrido[1,2-e]purine derivatives

Liquid Native MALDI Mass Spectrometry for the Detection of Protein-Protein Complexes

Repair of 8-oxo-7,8-dihydroguanine in prokaryotic and eukaryotic cells: Properties and biological roles of the Fpg and OGG1 DNA N -glycosylases

The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase

ATP-dependent motor activity of the transcription termination factor Rho from Mycobacterium tuberculosis

Backbone assignment of the three dimers of HU from Escherichia coli at 293 K: EcHUα2, EcHUβ2 and EcHUαβ

Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea

Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization

The orientation of the C-terminal domain of the Saccharomyces cerevisiae Rap1 protein is determined by its binding to DNA

Binding of the RamR repressor to wild-type and mutated promoters of the RamA gene involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.

5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases

An alternative flexible conformation of the E. coli HU beta(2) protein: structural, dynamics, and functional aspects

Scaling of ac electrical conductivity of powders under compression

Complex oligomeric structure of a truncated form of DdrA: A protein required for the extreme radiotolerance of Deinococcus.

Bacterial base excision repair enzyme Fpg recognizes bulky N7-substituted-FapydG lesion via unproductive binding mode.

Some aspects of electrical conduction in granular systems of various dimensions

Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by Formamidopyrimidine-DNA glycosylase

Location and base selectivity on fragmentation of brominated oligodeoxynucleotides

Modification of DNA radiolysis by DNA-binding proteins: structural aspects

BER: (Base excision repair): molecular mechanisms and biological roles

Radiolysis of DNA-protein complexes

Structural insights into abasic site for Fpg specific binding and catalysis: comparative high-resolution crystallographic studies of Fpg bound to various models of abasic site analogues containing DNA

Insights into the DNA repair process by the formamidopyrimidine-DNA glycosylase investigated by molecular dynamics

Radiation affects binding of Fpg repair protein to an abasic site containing DNA

Recognition of cyclonucleoside lesions by the Lactococcus lactis FPG protein

Evidence of a thermal unfolding dimeric intermediate for the Escherichia coli histone-like HU proteins: thermodynamics and structure.

Crystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA

Crystallization and preliminary X-ray crystallographic studies of a complex between the Lactococcus lactis Fpg DNA-repair enzyme and an abasic site containing DNA

Catalytic and DNA binding properties of the ogg1 protein of Saccharomyces cerevisiae: comparison between the wild type and the K241R and K241Q active-site mutant proteins.

AP site structural determinants for Fpg specific recognition

Crystallization and preliminary X-ray diffraction analysis of the homodimeric form alpha2 of the HU protein from Escherichia coli.

Synthesis of an Enantiomerically Pure Carbocyclic DNA Abasic Site Analogue

HU Protein of Escherichia coli Binds Specifically to DNA That Contains Single-strand Breaks or Gaps

Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role.

Cleavage and binding of a DNA fragment containing a single 8-oxoguanine by wild type and mutant FPG proteins

DNA containing a chemically reduced apurinic site is a high affinity ligand for the E.coli formamidopyrimidine-DNA glycosyiase

Purification and characterization of the Saccharomyces cerevisiae mitochondrial leucyl-tRNA synthetase.

Architecture et dynamique de protéines histone-like de bactérie et d’archées

Inhibition des ADN glycosylases de la super famille structurale Fpg/Nei par des thiopurines: relations structure-activité

Vers une description cinétique et structurale complète du mécanisme d'échange de chaînes de la protéine HU d'Escherichia coli.

Les ADN glycosylases qui initient le système de réparation de l'ADN par excision de base, de nouvelles cibles potentielles pour lutter contre le cancer

Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy

Small molecule inhibitors of the human DNA glycosylases hOGG1 and NEIL1, pertinent therapeutic targets in cancer and neurodegenerative disease therapies

Des cristaux pour la recherche de nouveaux antiviraux

Screening, characterization and structural studies of small molecules inhibitors of the DNA glycosylase hNEIL1 and hOGG1, potential therapeutic targets in cancer and neurodegenerative disease

To a complete kinetics and structural description of the EcHU chain exchange system

Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer

Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer

Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity

To a complete kinetics and structural description of the EcHU chain exchange system.

Interaction de la protéine NS1 des virus influenza A avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique

Native and Intermediate conformations of the three HU dimers of E.coli.

Recherche d’inhibiteurs des enzymes de réparation de l’ADN hNeil1 et hOGG1, de nouvelles cibles pertinentes pour le développement de thérapies anticancéreuses

NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales

Search for small molecule inhibitors of DNA glycosylases, pertinent therapeutic targets in cancer and neurodegenerative disease therapies

New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure.

First kinetics description of the EcHU chain exchange system.

To a complete kinetics and structural description of the EcHU chain exchange system.

Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity

Premières études cinétiques du mécanisme d’échange de chaînes de la protéine HU d’Escherischia coli.

Premières études cinétiques du mécanisme d’échange de chaînes de la protéine HU d’Escherischia coli.

New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure.

Structures et fonctions de la protéine NS1 des virus influenza pour la recherche de nouvelles cibles thérapeutiques

New protein-DNA complexes in archaea: a small monomeric protein induces a V-turn structure.

NS1 des virus influenza : relations structure-fonction pour la recherche de nouveaux anti-viraux

New protein-DNA complexes in archaea: a monomeric protein induces a U-turn structure.

NS1 des virus Influenza A : approches structurales et fonctionnelles pour de nouvelles stratégies anti-virales

NS1 of Influenza viruses: structural and functional approaches towards the discovery of novel anti-influenza drugs

Première description cinétique du mécanisme d’échange de chaînes de la protéine HU d'Escherichia coli.

The MC1-DNA complex solution structure reveals that a monomeric protein can induce a U-turn in archaea.