Researcher identifiers

Co-authors

Number of documents

36

Publications de Benjamin Gourbal


As a comparative immunologist with interests in the evolution of immunity, my work focus on gaining a deeper understanding of invertebrate innate immune systems and their modulation. I work mainly on one model: the snail Biomphalaria glabrata and its trematode parasite Schistosoma mansoni, in which I investigate the mechanisms that determine the compatibility polymorphism, the specificity, and regulation of innate immune response. Finally I investigate also the molecular mechanisms of immune priming or innate immune memory in B. glabratasnails. Through collaborations this last question will be also applied to viral immune priming for the mollusk Crassostrea gigas and to trans-generational immune priming” (TGIP) for the arthropod Tenebrio molitor.

To solve our objectives (i) different comparative molecular approaches were developed at genomic level (NGS DNA sequencing), transcriptomic level (RNASeq, Q-RT-PCR) and proteomic level (protein enrichment, 2D-gel, 2D-DIGE, interactome) and (ii) functional approaches were conducted (recombinant proteins, RNA-interference, in-vitro culture).

For more details please follow the link hereafter: 

http://ihpe.univ-perp.fr/ihpe-gourbal-benjamin/


Journal articles36 documents

  • Anaïs Portet, Silvain Pinaud, Cristian Chaparro, Richard Galinier, Nolwenn Dheilly, et al.. Sympatric versus allopatric evolutionary contexts shape differential immune response in Biomphalaria / Schistosoma interaction. PLoS Pathogens, Public Library of Science, 2019, 15 (3), pp.e1007647. ⟨10.1371/journal.ppat.1007647⟩. ⟨hal-02076267⟩
  • Silvain Pinaud, Anaïs Portet, Jean-François Allienne, Lucid Belmudes, Cécile Saint-Beat, et al.. Molecular characterisation of immunological memory following homologous or heterologous challenges in the schistosomiasis vector snail, Biomphalaria glabrata. Developmental and Comparative Immunology, Elsevier, 2019, 92, pp.238-252. ⟨hal-01952235⟩
  • Euan R.O. Allan, Benjamin Gourbal, Camila Dores, Anaïs Portet, Christopher Bayne, et al.. Clearance of schistosome parasites by resistant genotypes at a single genomic region in Biomphalaria glabrata snails involves cellular components of the hemolymph. International Journal for Parasitology, Elsevier, 2018, 48 (5), pp.387 - 393. ⟨10.1016/j.ijpara.2017.08.008⟩. ⟨hal-01808560⟩
  • Anaïs Portet, Richard Galinier, Silvain Pinaud, Julien Portela, Fanny Nowacki, et al.. BgTEP: an antiprotease involved in innate immune sensing in Biomphalaria glabrata. Frontiers in Immunology, Frontiers, 2018, 9, pp.1206. ⟨10.1101/308130⟩. ⟨hal-01838951⟩
  • Annia Alba, Antonio Vázquez, Jorge Sánchez, David Duval, Hilda Hernández, et al.. Fasciola hepatica-Pseudosuccinea columella interaction: effect of increasing parasite doses, successive exposures and geographical origin on the infection outcome of susceptible and naturally-resistant snails from Cuba. Parasites and Vectors, BioMed Central, 2018, 11, pp.559. ⟨10.1186/s13071-018-3155-3⟩. ⟨hal-02007549⟩
  • Annia Alba, Antonio Vázquez, Jorge Sánchez, David Duval, Hilda Hernández, et al.. Fasciola hepatica-Pseudosuccinea columella interaction: effect of increasing parasite doses, successive exposures and geographical origin on the infection outcome of susceptible and naturally-resistant snails from Cuba. Parasites and Vectors, BioMed Central, 2018, 11, pp.559. ⟨10.1186/s13071-018-3155-3⟩. ⟨hal-01912747⟩
  • Benjamin Gourbal, Silvain Pinaud, Gerold Beckers, Jos van der Meer, Uwe Conrath, et al.. Innate immune memory: An evolutionary perspective. Immunological Reviews, Wiley, 2018, 283 (1), pp.21 - 40. ⟨10.1111/imr.12647⟩. ⟨hal-01792968⟩
  • Guillaume Mitta, Benjamin Gourbal, Christoph Grunau, M. Knight, J.M. Bridger, et al.. The compatibility between Biomphalaria glabrata snails and Schistosoma mansoni: an increasingly complex puzzle. Advances in Parasitology, Elsevier, 2017, 97, pp.111-145. ⟨10.1016/bs.apar.2016.08.006⟩. ⟨hal-01511043⟩
  • Richard Galinier, Emmanuel Roger, Yves Moné, David Duval, Anaïs Portet, et al.. A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni. PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (3), pp.e0005398. ⟨http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005398⟩. ⟨10.1371/journal.pntd.0005398.s005⟩. ⟨hal-01511153⟩
  • C. Adema, L. Hillier, C. Jones, E.S. Loker, M. Knight, et al.. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications, Nature Publishing Group, 2017, 8, pp.15451. ⟨https://www.nature.com/articles/ncomms15451⟩. ⟨10.1038/ncomms15451⟩. ⟨hal-01523953⟩
  • Maxime Lafont, Bruno Petton, Agnès Vergnes, Marianna Pauletto, Amélie Segarra, et al.. Long-lasting antiviral innate immune priming in the Lophotrochozoan Pacific oyster, Crassostrea gigas. Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.13143. ⟨10.1038/s41598-017-13564-0⟩. ⟨hal-01632346⟩
  • Anaïs Portet, Silvain Pinaud, Guillaume Tetreau, Richard Galinier, Céline Cosseau, et al.. Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP- Sm PoMuc interaction. Developmental and Comparative Immunology, Elsevier, 2017, 75, pp.16 - 27. ⟨10.1016/j.dci.2017.02.025⟩. ⟨hal-01598455⟩
  • Guillaume Tetreau, Silvain Pinaud, Anaïs Portet, Richard Galinier, Benjamin Gourbal, et al.. Specific Pathogen Recognition by Multiple Innate Immune Sensors in an Invertebrate. Frontiers in Immunology, Frontiers, 2017, 8, pp.1249. ⟨10.3389/fimmu.2017.01249⟩. ⟨hal-01729395⟩
  • Richard Galinier, Guillaume Tetreau, Anaïs Portet, Silvain Pinaud, David Duval, et al.. First characterization of viruses from freshwater snails of the genus Biomphalaria, the intermediate host of the parasite Schistosoma mansoni. Acta Tropica, Elsevier, 2017, 167, pp.196-203. ⟨http://www.sciencedirect.com/science/article/pii/S0001706X1630715X⟩. ⟨10.1016/j.actatropica.2016.12.021⟩. ⟨hal-01435053⟩
  • Richard Galinier, Guillaume Tetreau, Anaïs Portet, Silvain Pinaud, David Duval, et al.. First characterization of viruses from freshwater snails of the genus Biomphalaria , the intermediate host of the parasite Schistosoma mansoni. Acta Tropica, Elsevier, 2017, 167, pp.196-203. ⟨hal-01988464⟩
  • Silvain Pinaud, Julien Portela, David Duval, Fanny Nowacki,, Marie-Aude Olive, et al.. A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata. PLoS Pathogens, Public Library of Science, 2016, 12 (1), pp.e1005361. ⟨http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005361⟩. ⟨10.1371/journal.ppat.1005361⟩. ⟨hal-01259482⟩
  • Silvain Pinaud, Julien Portela, David Duval, Fanny Nowacki, Marie-Aude Olive, et al.. A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata. PLoS Pathogens, Public Library of Science, 2016, 12 (1), pp.e1005361. ⟨10.1371/journal.ppat.1005361⟩. ⟨hal-02191477⟩
  • David Duval, Richard Galinier, Gabriel Mouahid, Eve Toulza, Jean-François Allienne, et al.. A Novel Bacterial Pathogen of Biomphalaria glabrata: A Potential Weapon for Schistosomiasis Control?. PLoS Neglected Tropical Diseases, Public Library of Science, 2015, 9 (2), pp.e0003489. ⟨10.1371/journal.pntd.0003489.s002⟩. ⟨hal-01162649⟩
  • Christine Coustau, Benjamin Gourbal, David Duval, T.P. Yoshino, C. M. Adema, et al.. Advances in gastropod immunity from the study of the interaction between the snail Biomphalaria glabrata and its parasites: A review of research progress over the last decade. Fish and Shellfish Immunology, Elsevier, 2015, 46 (1), pp.5-16. ⟨10.1016/j.fsi.2015.01.036⟩. ⟨hal-01162871⟩
  • Nolwenn M Dheilly, Fanny Maure, Marc Ravallec, Richard Galinier, Josée Doyon, et al.. Who is the puppet master? Replication of a parasitic wasp-associated virus correlates with host behaviour manipulation. Proceedings of the Royal Society B: Biological Sciences, Royal Society, The, 2015, 282 (1803), pp.20142773. ⟨10.1098/rspb.2014.2773⟩. ⟨hal-01141139⟩
  • Nolwenn M Dheilly, David Duval, Gabriel Mouahid, Rémi Emans, Jean-François Allienne, et al.. A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata. Developmental and Comparative Immunology, Elsevier, 2015, 48 (1), pp.234-243. ⟨http://www.sciencedirect.com/science/article/pii/S0145305X14002560#⟩. ⟨10.1016/j.dci.2014.10.009⟩. ⟨hal-01082870⟩
  • Nolwenn M Dheilly, Coen Adema, David A Raftos, Benjamin Gourbal, Christoph Grunau, et al.. No more non-model species: The promise of next generation sequencing for comparative immunology.. Developmental and Comparative Immunology, Elsevier, 2014, 45 (1), pp.56-66. ⟨10.1016/j.dci.2014.01.022⟩. ⟨halsde-00965375⟩
  • Audrey Sophie Vanhove, Marylise Duperthuy, Guillaume M Charrière, Frédérique Le Roux, David Goudenège, et al.. Outer membrane vesicles are vehicles for the delivery of Vibrio tasmaniensis virulence factors to oyster immune cells.. Environmental Microbiology, Wiley-Blackwell, 2014, 17 (4), pp.1152-65. ⟨10.1111/1462-2920.12535⟩. ⟨halsde-01054322⟩
  • Julien Portela, David Duval, Anne Rognon, Richard Galinier, Jérôme Boissier, et al.. Evidence for Specific Genotype-Dependent Immune Priming in the Lophotrochozoan Biomphalaria glabrata Snail.. Journal of Innate Immunity, Karger, 2013, 5 (3), pp.261-276. ⟨10.1159/000345909⟩. ⟨halsde-00790554⟩
  • Olga Lucia Baron, Pieter van West, Benoit Industri, Michel Ponchet, Géraldine Dubreuil, et al.. Parental Transfer of the Antimicrobial Protein LBP/BPI Protects Biomphalaria glabrata Eggs against Oomycete Infections.. PLoS Pathogens, Public Library of Science, 2013, 9 (12), pp.e1003792. ⟨10.1371/journal.ppat.1003792⟩. ⟨hal-00938929⟩
  • Richard Galinier, Julien Portela, Yves Moné, Jean-François Allienne, Hélène Henri, et al.. Biomphalysin, a new β pore-forming toxin involved in Biomphalaria glabrata immune defense against Schistosoma mansoni.. PLoS Pathogens, Public Library of Science, 2013, 9 (3), pp.e1003216. ⟨10.1371/journal.ppat.1003216⟩. ⟨halsde-00823685⟩
  • Julien Portela, Jérôme Boissier, Benjamin Gourbal, Vincent Pradines, Vincent Collière, et al.. Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni. PLoS Neglected Tropical Diseases, Public Library of Science, 2012, 6 (2), pp.e1474. ⟨10.1371/journal.pntd.0001474⟩. ⟨halsde-00670260⟩
  • Emeline Deleury, Géraldine Dubreuil, Namasivayam Elangovan, Eric Wajnberg, Jean-Marc Reichhart, et al.. Specific versus non-specific immune responses in an invertebrate species evidenced by a comparative de novo sequencing study.. PLoS ONE, Public Library of Science, 2012, 7 (3), pp.e32512. ⟨10.1371/journal.pone.0032512⟩. ⟨halsde-00700368⟩
  • Yves Moné, Anne-Cécile Ribou, Céline Cosseau, David Duval, André Théron, et al.. An example of molecular co-evolution: Reactive oxygen species (ROS) and ROS scavenger levels in Schistosoma mansoni/Biomphalaria glabrata interactions.. International Journal for Parasitology, Elsevier, 2011, 41 (7), pp.721-730. ⟨10.1016/j.ijpara.2011.01.007⟩. ⟨halsde-00580768⟩
  • Jean-François Allienne, André Théron, Benjamin Gourbal. Recovery of primary sporocysts in vivo in the Schistosoma mansoni/Biomphalaria glabrata model using a simple fixation method suitable for extraction of genomic DNA and RNA.. Experimental Parasitology, Elsevier, 2011, 129 (1), pp.11-16. ⟨10.1016/j.exppara.2011.06.003⟩. ⟨halsde-00612896⟩
  • Yves Moné, Benjamin Gourbal, David Duval, Louis Du Pasquier, Sylvie Kieffer-Jaquinod, et al.. A large repertoire of parasite epitopes matched by a large repertoire of host immune receptors in an invertebrate host/parasite model. PLoS Neglected Tropical Diseases, Public Library of Science, 2010, 4 (9), pp.e813. ⟨10.1371/journal.pntd.0000813⟩. ⟨halsde-00515823⟩
  • Alvaro Baeza Garcia, Raymond Pierce, Benjamin Gourbal, Elisabeth Werkmeister, Dominique Colinet, et al.. Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni.. PLoS Pathogens, Public Library of Science, 2010, 6 (9), pp.e1001115. ⟨10.1371/journal.ppat.1001115⟩. ⟨halsde-00608628⟩
  • Yves Moné, Guillaume Mitta, David Duval, Benjamin E F Gourbal. Effect of amphotericin B on the infection success of Schistosoma mansoni in Biomphalaria glabrata.. Experimental Parasitology, Elsevier, 2010, 125 (2), pp.70-5. ⟨10.1016/j.exppara.2009.12.024⟩. ⟨halsde-00495366⟩
  • Emmanuel Roger, Christoph Grunau, Raymond Pierce, Hirohisa Hirai, Benjamin Gourbal, et al.. Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata).. PLoS Neglected Tropical Diseases, Public Library of Science, 2008, 2 (11), pp.e330. ⟨10.1371/journal.pntd.0000330⟩. ⟨halsde-00344615⟩
  • François Guillou, Emmanuel Roger, Yves Moné, Anne Rognon, Christoph Grunau, et al.. Excretory-secretory proteome of larval Schistosoma mansoni and Echinostoma caproni, two parasites of Biomphalaria glabrata.. Molecular and Biochemical Parasitology, Elsevier, 2007, 155 (1), pp.45-56. ⟨10.1016/j.molbiopara.2007.05.009⟩. ⟨hal-00170690⟩
  • Baptiste Vergnes, Benjamin Gourbal, Isabelle Girard, Shyam Sundar, Jolyne Drummelsmith, et al.. A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death.. Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2007, 6 (1), pp.88-101. ⟨10.1074/mcp.M600319-MCP200⟩. ⟨hal-00170702⟩