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Béatrice Vallée

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Documents

Publications

helene-benedetti
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LIM Kinases: From Molecular to Pathological Features

Hélène Bénédetti , Béatrice Vallée
Cells, 2023, 12 (12), pp.1649. ⟨10.3390/cells12121649⟩
Article dans une revue hal-04208415v1
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LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features

Elodie Villalonga , Christine Mosrin , Thierry Normand , Caroline Girardin , Amandine Serrano
Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩
Article dans une revue hal-04208405v1
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Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper

Bojan Žunar , Christine Mosrin-Huaman , Hélène Bénédetti , Béatrice Vallée
Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩
Article dans une revue hal-03820214v1
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LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo

Rayan Berabez , Sylvain Routier , Hélène Bénédetti , Karen Plé , Béatrice Vallée
Cells, 2022, 11 (13), pp.2090. ⟨10.3390/cells11132090⟩
Article dans une revue hal-03721458v1
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Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors

Frédéric Buron , Nuno Rodrigues , Thibault Saurat , Marie-Aude Hiebel , Stéphane Bourg
Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Article dans une revue hal-03348966v1
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Neurofibromin Structure, Functions and Regulation

Mohammed Bergoug , Michel Doudeau , Fabienne Godin , Christine Mosrin-Huaman , Béatrice Vallée
Article dans une revue hal-03070759v2
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Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein

Béatrice Vallée , Michel Doudeau , Fabienne Godin , Hélène Bénédetti
Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩
Article dans une revue hal-02282630v1

LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability

Julie Tastet , Hélène Cuberos , Béatrice Vallée , Annick Toutain , Martine Raynaud
Neuroscience, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩
Article dans une revue hal-02067472v1

LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b

Béatrice Vallée , Hélène Cuberos , Michel Doudeau , Fabienne Godin , David Gosset
Biochemical Journal, 2018, 475 (23), pp.3745-3761
Article dans une revue hal-01966439v1

Roles of LIM kinases in central nervous system function and dysfunction

H. Cuberos , B. Vallée , P. Vourc'H , J. Tastet , C.R. Andres
FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩
Article dans une revue hal-02072231v1

Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.

Martine Beaufour , Fabienne Godin , Béatrice Vallée , Martine Cadene , Hélène Bénédetti
Journal of Proteome Research, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩
Article dans une revue hal-00721771v1

LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain

Julie Tastet , Patrick Vourc'H , Frédéric Laumonnier , Béatrice Vallée , Carole Michelle
Biochemical and Biophysical Research Communications, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩
Article dans une revue hal-01136281v1

A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.

Fabienne Godin , Sandrine Villette , Béatrice Vallée , Michel Doudeau , Séverine Morisset-Lopez
Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩
Article dans une revue hal-00721861v1
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Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways

Béatrice Vallée , Michel Doudeau , Fabienne Godin , Aurélie Gombault , Aurélie Tchalikian-Cosson
PLoS ONE, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩
Article dans une revue hal-03054185v1

A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY

Aurélie Gombault , Jonas Warringer , Robert Caesar , Fabienne Godin , Béatrice Vallée
FEMS Yeast Research, 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩
Article dans une revue hal-00522432v1

Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study

Aurélie Gombault , Fabienne Godin , Denise Sy , Baptiste Legrand , Hélène Chautard
Journal of Molecular Biology, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩
Article dans une revue hal-00181161v1

Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action

Justine Corret , Sokaina Hammoud , Frédéric Buron , Pierre Daligaux , Christophe Chesné
FEBS 2021, the 45th FEBS Congress, Jul 2021, Virtual, France
Communication dans un congrès hal-03668584v1

High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells

N Laroui , C Delehedde , C Goncalves , F Godin , Federico Perche
SFNano 2021, Dec 2021, Angers, France
Communication dans un congrès hal-03668422v1

Séminaire invité : Signalisation cellulaire et Neurofibromatose

Béatrice Vallée , Hélène Bénédetti
Journées NF, Sep 2021, Orléans, France
Communication dans un congrès hal-03560050v1

Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel

Béatrice Vallée , Christine Mosrin-Huaman , Hélène Bénédetti , Régis Guégan , Bojan Zunar
ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria
Communication dans un congrès hal-03559939v1

Les LIM kinases : nouvelles cibles thérapeutiques anti-cancer

H. Bénédetti , Béatrice Vallée , A. Cosson , F. Godin , M. Doudeau
Journée scientifique du réseau « Cancers hormonaux–dépendants » du Cancéropôle Grand-Ouest, Apr 2019, Nantes, France
Communication dans un congrès hal-02928496v1

Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease

M. Bergoug , A. Cosson , D. Casas , M. Doudeau , F. Godin
6th LIA Workshop on "Biomarkers and mediators of diseases and new approaches in repair/regenerative therapies, Jun 2019, Varsovie, Poland
Communication dans un congrès hal-02928511v1

Détermination et mise en œuvre d’un modèle in vivo pour tester de nouveaux inhibiteurs originaux des LIM kinases, cibles thérapeutiques émergentes dans le cancer

Béatrice Vallée , K. Plé , A. Cosson , M. Doudeau , F. Godin
Cancéropôle Grand Ouest, Colloque du Réseau Molécules marines, métabolisme et cancer, May 2019, Mansigné, France
Communication dans un congrès hal-02928507v1

Développement de modulateurs des LIM kinases

Béatrice Vallée , S. Routier , A. Cosson , M. Doudeau , F. Godin
Cancéropôle Grand Ouest - 14e colloque du Réseau Produits de la mer en cancérologie - 5e colloque du Réseau Canaux ioniques et cancer, May 2018, Mansigné, France
Communication dans un congrès hal-02928559v1

Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose

Béatrice Vallée , Karen Plé , A. Cosson , M. Doudeau , F. Godin
Journée Fédération CBM-ICOA, Jan 2018, Orléans, France
Communication dans un congrès hal-02928530v1

Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1

M. Bergoug , A. Cosson , M. Doudeau , F. Godin , Béatrice Vallée
Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France
Communication dans un congrès hal-02928220v1

Neurofibromatosis type I: from basic to applied research

Béatrice Vallée , A. Cosson , M. Doudeau , F Godin , A. Braka
4th LIA Workshop, Jun 2017, Cracovie, Poland
Communication dans un congrès hal-02928517v1

Study of new partners of neurofibromin: an approach to identify novel therapeutic targets for neurofibromatosis type 1

Béatrice Vallée , Hélène Bénédetti , F. Godin , M. Doudeau
17th European Neurofibromatosis meeting, Sep 2016, Albano-Terme, Italy
Communication dans un congrès hal-02928226v1

Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements

Christine Mosrin-Huaman , Mohammed Bergoug , Fabienne Godin , Michel Doudeau , Iva Sosic
2021 NF1 virtual conference, Jun 2021, Virtual, France
Poster de conférence hal-03680001v1

New insights into the regulation of actin cytoskeleton dynamics via the Rho/ROCK/LIMK2/cofilin signalling pathway: a novel mechanism of regulation of cofilin by LIMK2

Elodie Villalonga , Célina Chalal , Déborah Cassas , Michel Doudeau , Fabienne Godin
FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, virtual, Slovenia
Poster de conférence hal-03680139v1

Sumoylation of neurofibromin and its SecPH domain plays a role in their functions and implies unexpected structural requirements

Christine Mosrin-Huaman , Mohammed Bergoug , Fabienne Godin , Michel Doudeau , Iva Sosic
FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia
Poster de conférence hal-03679991v1

High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells

N Laroui , C Delehedde , Cristine Gonçalves , F Godin , F Perche
10th mRNA Health Conference, Nov 2021, Berlin, Germany
Poster de conférence hal-03668434v1

Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development

Bojan Zunar , Christine Mosrin-Huaman , Hélène Bénédetti , Régis Guégan , Béatrice Vallée
FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia
Poster de conférence hal-03679975v1

Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action

Justine Corret , Sokaina Hammoud , Frédéric Buron , Pierre Daligaux , Christophe Chesné
FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia
Poster de conférence hal-03679980v1

New molecular insights into the crosstalk between Rho/ROCK/LIMK2/cofilin signalling pathway and Nf1

Mélissa Thomas , Lauren Blot , Kevin Lesage , Fabienne Godin , Michel Doudeau
2021 NF1 virtual conference, Jun 2021, Virtual, France
Poster de conférence hal-03679999v1

LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors

Béatrice Vallée , A. Cosson , M. Doudeau , F. Godin , A. Champiré
FEBS Meeting 2019, Jul 2019, Cracovie, Poland
Poster de conférence hal-02924140v1

Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease

M. Bergoug , I. Sošic , M. Doudeau , F. Godin , Béatrice Vallée
EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia
Poster de conférence hal-02924095v1

Study of the different forms of sumoylation of the neurofibromin SecPH domain

H. Bénédetti , M. Bergoug , I. Sošic , M. Doudeau , F. Godin
EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia
Poster de conférence hal-02924090v1

Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability

H. Bénédetti , Béatrice Vallée , J. Tastet , H. Cubéros , A. Toutain
NeuroFrance 2019, May 2019, Marseille, France
Poster de conférence hal-02924881v1

Yeast biosensors to detect environmental pollutants into effluent waters

Christine Mosrin-Huaman , B. Handelaoui , H. Bénédetti , Béatrice Vallée
ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden
Poster de conférence hal-02924111v1

LARP6, a RNA−binding protein involved in translation and stability of collagen mRNA, is a new partner of Neurofibromin: Molecular studies and functional implications

H. Bénédetti , M. Doudeau , F. Godin , Béatrice Vallée , A. Cosson
Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France
Poster de conférence hal-02924084v1

Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I

Béatrice Vallée , A. Cosson , M. Doudeau , F. Godin , A. Champiré
Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France
Poster de conférence hal-02924077v1

Design, synthesis and biological evaluation of LIMK inhibitors

A. Champiré , A. Braka , Béatrice Vallée , M. Doudeau , F. Godin
XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France
Poster de conférence hal-02904837v1

Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1

M. Bergoug , A. Cosson , M. Doudeau , F. Godin , Béatrice Vallée
EMBO Conference "Ubiquitin and SUMO: from molecular mechanisms to system-wide responses, Sep 2017, Cavtat, Croatia
Poster de conférence hal-02924070v1

LIM Kinases: new anticancer therapeutic targets

Béatrice Vallée , A. Cosson , M. Doudeau , F. Godin , Anthony Champiré
Breast Cancer Symposium, Jun 2017, Nantes, France
Poster de conférence hal-03680148v1

Projet Région LiCorNe: LIMK protein inhibitors, new therapeutic agents for treatment of cognitive disorders associated with type I Neurofibromatosis

Béatrice Vallée , Michel Doudeau , F. Godin , H. Cubéros , A. Champiré
Journée Fédération PCV FR2708, Jan 2016, Orléans, France
Poster de conférence hal-02924056v1

LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability

Béatrice Vallée , Hélène Cuberos , Julie Tastet , Michel Doudeau , Fabienne Godin
10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark.
Poster de conférence hal-02453486v1

LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications

Hélène Bénédetti , Fabienne Godin , Michel Doudeau , Béatrice Vallée , Marie-Ludivine De Tauzia
10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark
Poster de conférence hal-02453487v1

The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways

Béatrice Vallée , Hélène Cuberos , Michel Doudeau , Fabienne Godin , Patrick Vourc’h
EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany.
Poster de conférence hal-02453489v1

Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases

A. Champiré , A. Braka , Béatrice Vallée , M. Doudeau , F. Godin
29e colloque de Biotechnocentre, Oct 2016, Seillac, France
Poster de conférence hal-02904847v1

LIM kinases: new therapeutic targets to treat Neurofibromatosis type I

Béatrice Vallée , Michel Doudeau , Fabienne Godin , Anthony Champiré , Karen Plé
The 7th EMBO meeting, Sep 2016, Mannheim, Germany.
Poster de conférence hal-02453490v1