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Ata Martin LAWSON

Maître de conférences (HDR), URCOM
25
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Présentation

![](https://) Ata Martin LAWSON was born in Tsévié (Togo) in 1974. He studied at Joseph Fourier University of Grenoble, France, graduating in 2002. He worked on aurone analogs’ synthesis as potent P-gp (P-glycoprotein) inhibitors in DPM Laboratory with Pr. Ahcene Boumendjel. He also worked on flavonoid synthesis in the same laboratory. In October 2002, he moved to the University of Limoges as PhD student where he has been interested in the extraction of rotenoids and, the chemistry of natural polyphenols of the Fabaceae family. After becoming a doctor by defending his PhD in 2006, he moved to the University of Reims as an Assistant Professor in the Medicinal Chemistry Laboratory of Pr. Janos Sapi. He stayed there for two years before acquiring a permanent position as an Associate Professor at Le Havre University in 2009. He then joined the team of Pr. Adam DAÏCH at URCOM laboratory. His current research interests include natural product chemistry (phytochemistry) as well as the synthesis of novel heterocycles using chromone derivatives as starting materials following The DOS (Diversity Oriented Synthesis) strategy and finally the development of hybrid molecules synthesis with diverse biological activities. **# 1. L'axe de recherche : Axe 1. Chimie durable et Santé** **# 2. Thème de recherche** **# 3. Mots-clés** **# 4. Production Scientifique** Publications : 48 Chapitres de livre : 0 Conférences invitées : 15 .

Domaines de recherche

Chimie organique Chimie thérapeutique

Compétences

Synthèse organique Réactions domino Extraction et modification de produits naturels Synthèse de molécules hybrides Activité anticancer, antibactérienne, antibiofilm et antifongique

Publications

"mohamed-othman"

Indolylglycines Backbones in the Synthesis of Enantiopure 3,3-Spiroindolenines, Indolyl Tetracyclic Hemiaminals, and 3-Indolyl-maleimides Frameworks

Jozef Markus , Branislav Ferko , Dušan Berkeš , Ján Moncol , Ata Martin Lawson
European Journal of Organic Chemistry, 2019, 2019 (33), pp.5662-5677. ⟨10.1002/ejoc.201900814⟩
Article dans une revue hal-02332612v1

Highly Enantioselective Semisynthesis of (+)/(−)-Gossypol Schiff Base Derivatives from Ground Plant Material

Mohamed Sidi Boune , Brahim Elemine , Ahmed Aliyenne , Abderrahmane Hadou , Adam Daïch
Journal of Natural Products, 2019, 82 (7), pp.1779-1790. ⟨10.1021/acs.jnatprod.8b01045⟩
Article dans une revue hal-02332614v1

Access to 3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species: a new family of potent farnesyltransferase inhibitors

Anthony Pesquet , Hamid Marzag , Michael Knorr , Carsten Strohmann , Ata Martin Lawson
Organic & Biomolecular Chemistry, 2019, 17 (10), pp.2798-2808. ⟨10.1039/c8ob02612b⟩
Article dans une revue hal-02332627v1
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Benzo[7,8]indolizinoquinoline scaffolds based on Mg(ClO4)2-promoted regiospecific imide reduction and π-cyclization of N-acyliminium species. Analogues of the topo-1 poison rosettacin and 22-hydroxyacuminatine alkaloids

Abdulkareem Hamid , Abdelaziz Souizi , Ata Martin Lawson , Mohamed Othman , Alina Ghinet
Arabian Journal of Chemistry, 2019, 12 (5), pp.680-693. ⟨10.1016/j.arabjc.2018.03.009⟩
Article dans une revue hal-02413296v1

Phenyliodine(III) Diacetate/I 2 ‐Mediated Domino Approach for Pyrrolo[1,4]Thiazines and 1,4‐Thiazines by a One‐Pot Morin Rearrangement of N,S ‐ Acetals

Fanny Danton , Mohamed Othman , Ata Martin Lawson , Ján Moncol , Alina Ghinet
Chemistry - A European Journal, 2019, 25 (24), pp.6113-6118. ⟨10.1002/chem.201901111⟩
Article dans une revue hal-02563783v1

Design and semisynthesis of new herbicide as 1,2,3-triazole derivatives of the natural maslinic acid

Aymen Ben Nejma , Mansour Znati , Adam Daïch , Mohamed Othman , Ata Martin Lawson
Steroids, 2018, 138, pp.102-107. ⟨10.1016/j.steroids.2018.07.004⟩
Article dans une revue hal-02332632v1

Structure-Based Kinetic Control in a Domino Process: A Powerful Tool Toward Molecular Diversity in Chromone Series

Thomas Lepitre , Clément Denhez , Jan Moncol , Mohamed Othman , Ata Martin Lawson
Journal of Organic Chemistry, 2017, 82 (23), pp.12188-12201. ⟨10.1021/acs.joc.7b01996⟩
Article dans une revue hal-02332616v1

Development of SECheM Concept for Isolation and Chemical Modification of Gossypol Directly from Cienfuegosia digitata

Mohamed Vall Sidi Boune , Brahim Ould Elemine , Thomas Lepitre , Abderrahmane Ould Hadou , Ahmed Aliyenne
Phytochemical Analysis, 2017, 28 (5), pp.410-415. ⟨10.1002/pca.2688⟩
Article dans une revue hal-02332630v1

Phytochemical and biological studies of Atriplex inflata f. Muell.: isolation of secondary bioactive metabolites

Aymen Ben Nejma , Mansour Znati , Asma Nguir , Adam Daïch , Mohamed Othman
Journal of Pharmacy and Pharmacology, 2017, 69 (8), pp.1064-1074. ⟨10.1111/jphp.12735⟩
Article dans une revue hal-02332617v1

Metal-Free Cascade Approach toward Polysubstituted Indolizines from Chromone-Based Michael Acceptors

Thomas Lepitre , Raphael Le Biannic , Mohamed Othman , Ata Martin Lawson , Adam Daïch
Organic Letters, 2017, 19 (8), pp.1978-1981. ⟨10.1021/acs.orglett.7b00309⟩
Article dans une revue hal-02332628v1

Original Mitsunobu-Triggered Sequence Involved in a One-Pot Domino Process toward Tetracyclic Systems Bearing a Bis- N , O -acetal Junction

Thomas Lepitre , Clément Denhez , Morgane Sanselme , Mohamed Othman , Ata Martin Lawson
Journal of Organic Chemistry, 2016, 81 (19), pp.8837 - 8849. ⟨10.1021/acs.joc.6b01523⟩
Article dans une revue hal-01928655v1
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Use of chiral-pool approach into epi-thieno analogues of the scarce bioactive phenanthroquinolizidine alkaloids

Peter Šafář , Štefan Marchalín , Nadežda Prónayová , Viktor Vrábel , Ata Martin Lawson
Tetrahedron, 2016, 72 (23), pp.3221-3231. ⟨10.1016/j.tet.2016.04.047⟩
Article dans une revue hal-02413311v1

New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities

Aymen Ben Nejma , Asma Nguir , Hichem Ben Jannet , M’hamed Ali Hamza , Adam Daïch
Bioorganic and Medicinal Chemistry Letters, 2015, 25 (8), pp.1665-1670. ⟨10.1016/j.bmcl.2015.03.028⟩
Article dans une revue hal-02413288v1

Preparation of (+) / (-)-gossypol Schiff base derivatives by SECheM methodology

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Ould Elemine , Abderrahmane Ould Hadou , Ahmed Aliyenne
Journées André Collet de la Chiralité JACC, Sep 2018, Noirmoutier, France
Communication dans un congrès hal-02568053v1

N,X-Acetals as Purinergic receptor P2RX7 ligands. Design and synthesis of N,S-backbones based on Morin rearrangement

Adam Daïch , Fanny Danton , Mohamed Othman , Ata Martin Lawson
Journée de l'école doctorale Normandie de Chimie JEDNC, Jun 2018, Le Havre, France
Communication dans un congrès hal-02567974v1

N,X Acetals : Ligands des récepteurs purinergiques P2X7

Adam Daïch , Fanny Danton , Mohamed Othman , Ata Martin Lawson
Journées Nord-Ouest Européennes des Jeunes Chercheurs, Jun 2018, Villeneuve d’Ascq, France
Communication dans un congrès hal-02568051v1

New methodology for synthesis of Schiff base derivatives of (aR)/(aS)-gossypol

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Elemine , Abderrahmane Ould Hadou , Mohamed Othman
Journée de l'école doctorale Normandie de Chimie JEDNC, Jun 2018, Le Havre, France
Communication dans un congrès hal-02567973v1

SECHEM Concept for Gossypol extraction and semi-synthesis directly from Cienfuegosia digitata

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Elemine , Thomas Lepitre , Abderrahmane Ould Hadou
Journée de l'école doctorale Normandie de Chimie JEDNC, Jun 2017, Rouen, France
Communication dans un congrès hal-02567969v1

A Simultaneous Extraction and Chemical Modification Concept: Application for Gossypol Extraction and Semi-synthesis Directly from Cienfuegosia digitata

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Elemine , Abderrahmane Ould Hadou , Mohamed Othman
Trends in Natural Product Research - PSE Young Scientists' Meeting Lille 2017, Natural Products in Health, Agro-Food and Cosmetics, Jun 2017, Lille, France
Communication dans un congrès hal-02568195v1

N,X-Acetals as Purinergic receptor P2X7 ligands. Design, synthesis and anti-cancer/anti-inflammatory evaluation

Adam Daïch , Fanny Danton , Mohamed Othman , Ata Martin Lawson
Journée de l'école doctorale Normandie de Chimie JEDNC, Jun 2017, Rouen, France
Communication dans un congrès hal-02567972v1

Original "one-pot" methodology combining extraction/chemical modification of gossypol from cienfuegosia digitata by traditional soxhlet system

Adam Daïch , Mohamed Vall Sidi Boune , Brahim Elemine , Abderrahmane Ould Hadou , Ahmed Aliyenne
Journées de Chimie Organique, Sep 2016, Palaiseau, France
Communication dans un congrès hal-02568193v1

Original Mitsunobu triggered sequence involved in a one-pot domino process

Adam Daïch , Thomas Lepitre , Ata Martin Lawson , Mohamed Othman
Journées de Chimie Organique, Sep 2016, Palaiseau, France
Communication dans un congrès hal-02568191v1

Competitive intramolecular C-C vs. C-O bond coupling reactions through C6 ring-fused 2-pyridones synthesis

Adam Daïch , Thomas Lepitre , Ata Martin Lawson , Mohamed Othman
13th Anglo-Norman Organic Chemistry Colloquium (ANORCQ XIII), Apr 2016, Rouen, France
Communication dans un congrès hal-02568190v1

Original Mitsunobu triggered sequence involved in a one-pot domino process

Adam Daïch , Thomas Lepitre , Ata Martin Lawson , Mohamed Othman
Journée de l'Ecole Doctorale Normande de Chimie, Jun 2016, Caen, France
Communication dans un congrès hal-02567967v1

Palladium Catalyzed Arylation vs Oxyarylation: Synthesis of C6 Ring-Fused Pyridones

Adam Daïch , Thomas Lepitre , Ata Martin Lawson , Mohamed Othman
Journées Nord-Ouest Européennes de Chimie (JNOEC), May 2015, Rouen, France
Communication dans un congrès hal-02568040v1