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Dr. Arnaud Monteil – Curriculum Vitae


Arnaud Monteil obtained his bachelor’s in biological sciences in 1989 in Montpellier (France). He then studied molecular biology and biochemistry at the University of Montpellier from 1989 to 1996. He started his PhD in 1996 under the supervision of Dr Joël Nargeot (University of Montpellier – Montpellier – France) with the objective to clone and characterize T-type voltage-gated calcium channels, a subtype of calcium channels that was not identified at this time. The thesis was successfully defended in 2000 and led to several publications of importance in the fields of ion channels and cellular excitability. After his thesis defense, Arnaud Monteil joined Prof Richard J. Miller’s laboratory as a post-doctoral fellow at the University of Chicago (Chicago – USA) where he identified and cloned a novel type of four-domain ion channel named NALCN. He went back to France in 2001 as a permanent researcher at the National Center for Scientific Research (CNRS). Since then Arnaud Monteil’s research is concerned with ion channels in Dr Philippe Lory’s team (« Ion channels in neuronal excitability and diseases » - Institut de Génomique Fonctionnelle – Montpellier ; Dr Philippe Lory’s team is part of the Laboratory of Excellence « Ion Channel Science and Therapeutics » ( The overall ambition ofthis laboratory of excellence is to become a world-wide recognized cluster in ion channel studies carrying research and innovation at the interface between biology and medicine. In this context, the research projects headed by Arnaud Monteil focus on the study of ion channels’ mutations involved in complex neurological disorders using molecular and electrophysiological techniques both in vitro (cell lines ; primary cultures) and in vivo (animal models). A special emphasis is to search for new molecules modulating ion channels activity that could be relevant to treat human diseases. Of note, Arnaud Monteil supervised 2-year exchange programs (Hubert-Curien Program 2013-2014 and 2020-2021) with Dr Narawut Pakaprot at Mahidol University (Thailand). In addition to his research activity, Arnaud Monteil is the head of a facility to produce viral vectors for research since 2008 (, is the president of the « Ion Channel » society since 2014 ( and leads the scientific committee of the Libellas foundation since 2020 ( Arnaud Monteil is also an elected member of the National Committee of the CNRS (CoNRS, Sub-committee #24 “Aging, Tumorigenesis, Physiology”) since 2016.




Journal articles17 documents

  • Alexandre Milman, Stephanie Venteo, Jean‐louis Bossu, Pierre Fontanaud, Arnaud Monteil, et al.. A sodium background conductance controls the spiking pattern of mouse adrenal chromaffin cells in situ. The Journal of Physiology, Wiley, 2021, ⟨10.1113/jp281044⟩. ⟨hal-03138604⟩
  • Philippe Lory, Sophie Nicole, Arnaud Monteil. Neuronal Cav3 channelopathies: recent progress and perspectives. Pflügers Archiv European Journal of Physiology, Springer Verlag, 2020, ⟨10.1007/s00424-020-02429-7⟩. ⟨hal-02893632⟩
  • Sineewanlaya Wichit, Rodolphe Hamel, Sakda Yainoy, Nuttamonpat Gumpangseth, Suchawadee Panich, et al.. Interferon-inducible protein (IFI) 16 regulates Chikungunya and Zika virus infection in human skin fibroblasts.. EXCLI Journal, 2019, 18, pp.467-476. ⟨10.17179/excli2019-1271⟩. ⟨hal-02328306⟩
  • Miriam Candelas, Ana Reynders, Margarita Arango-Lievano, Christoph Neumayer, Antoine Fruquière, et al.. Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons. Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-39703-3⟩. ⟨hal-02356250⟩
  • Malik Bouasse, Hathaichanok Impheng, Zoe Servant, Philippe Lory, Arnaud Monteil. Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties. Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-48071-x⟩. ⟨hal-02328271⟩
  • Jean Chemin, Valentina Taiakina, Arnaud Monteil, Michael Piazza, Wendy Guan, et al.. Calmodulin regulates Ca v 3 T-type channels at their gating brake. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (49), pp.20010-20031. ⟨10.1074/jbc.M117.807925⟩. ⟨hal-02328290⟩
  • J. X. Chong, M. J. Mcmillin, K. M. Shively, A. E. Beck, C. T. Marvin, et al.. De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay. American Journal of Human Genetics, Elsevier (Cell Press), 2015, 96 (3), pp.462-73. ⟨10.1016/j.ajhg.2015.01.003⟩. ⟨hal-02064371⟩
  • Arnaud Monteil, Patrick Chausson, Katia Boutourlinsky, Alexandre Mezghrani, Iulia Blesneac, et al.. Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (26), pp.16168-16176. ⟨10.1074/jbc.M114.634261⟩. ⟨hal-01348945⟩
  • Marie Coutelier, Iulia Blesneac, Arnaud Monteil, Marie-Lorraine Monin, Kunie Ando, et al.. A Recurrent Mutation in CACNA1G Alters Cav3.1 T-Type Calcium-Channel Conduction and Causes Autosomal-Dominant Cerebellar Ataxia. American Journal of Human Genetics, Elsevier (Cell Press), 2015, 97 (5), pp.726-737. ⟨10.1016/j.ajhg.2015.09.007⟩. ⟨hal-01223815⟩
  • Maud Cochet-Bissuel, Philippe Lory, Arnaud Monteil. The sodium leak channel, NALCN, in health and disease. Frontiers in Cellular Neuroscience, Frontiers, 2014, 8, pp.132. ⟨10.3389/fncel.2014.00132⟩. ⟨hal-01950130⟩
  • Adrienne N. Boone, Adriano Senatore, Jean Chemin, Arnaud Monteil, J. David Spafford. Gd3+ and calcium sensitive, sodium leak currents are features of weak membrane-glass seals in patch clamp recordings. PLoS ONE, Public Library of Science, 2014, 9 (6), pp.e98808. ⟨10.1371/journal.pone.0098808⟩. ⟨hal-01943334⟩
  • Norbert Weiss, Shahid Hameed, José Fernández-Fernández, Katell Fablet, Maria Karmazinova, et al.. A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (4), pp.2810-8. ⟨10.1074/jbc.M111.290882⟩. ⟨inserm-00757396⟩
  • Sylvaine Huc-Brandt, Arnaud Monteil, Isabelle Bidaud, Guillaume Barbara, Jean Chemin, et al.. Regulation of T-type calcium channels: Signalling pathways and functional implications. Biochimica et Biophysica Acta - Molecular Cell Research, Elsevier, 2009, 1793 (6), pp.947-952. ⟨10.1016/j.bbamcr.2008.11.003⟩. ⟨hal-02282056⟩
  • Sebastien Granier, Frederic Jean-Alphonse, Daniel Bacqueville, Arnaud Monteil, Robert Pascal, et al.. The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V-2 receptor. Regulatory Peptides, Elsevier, 2008, 148, pp.76-87. ⟨10.1016/j.regpep.2008.01.007⟩. ⟨hal-00493436⟩
  • Sébastien Granier, Frédéric Jean-Alphonse, Daniel Bacqueville, Arnaud Monteil, Robert Pascal, et al.. The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V2 receptor. Regulatory Peptides, Elsevier, 2008, 148 (1-3), pp.76-87. ⟨10.1016/j.regpep.2008.01.007⟩. ⟨hal-03117144⟩
  • Emmanuel Bourinet, A. Alloui, Arnaud Monteil, Christian Barrère, Brigitte Couette, et al.. Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. EMBO Journal, EMBO Press, 2005, 24, pp.315-324. ⟨10.1038/sj.emboj.7600515⟩. ⟨hal-00016908⟩
  • Christine Berthier, Arnaud Monteil, C. Strube, Philippe Lory. α 1H mRNA in single skeletal muscle fibres accounts for T‐type calcium current transient expression during fetal development in mice. The Journal of Physiology, Wiley, 2002, 539 (3), pp.681-691. ⟨10.1113/jphysiol.2001.013246⟩. ⟨hal-03093134⟩

Conference papers1 document

  • Philippe Lory, Jean Chemin, Arnaud Monteil, Nathalie C. Guérineau, Sophie Nicole, et al.. Deciphering pathogenic mechanisms underlying human calcium channelopathies. Congrès de la Société Française de Physiologie, Jun 2019, Montpellier, France. ⟨hal-03020963⟩