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27 résultats

	Pour les 27 documents Envoyer sur ORCID RSS ATOM Exporter BibTeX XML-TEI CSV RTF EndNote PDF HTML Export avancé	Page :	triés par Pertinence Auteur A→Z Auteur Z→A Titre A→Z Titre Z→A Date de publication croissante Date de publication décroissante Date de dépôt croissante Date de dépôt décroissante

		Prodrugs as new therapies against Chagas disease: In vivo synergy between Trypanosoma cruzi proline racemase inhibitors and benznidazole Guilherme Dias de Melo , Nicolas Coatnoan , Nicolas Gouault , Jean-François Cupif , Jacques Renault , et al. Journal of Global Antimicrobial Resistance, 2022, 28, pp.84-89. ⟨10.1016/j.jgar.2021.10.030⟩ Article dans une revue hal-03504248v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Principal Component Analysis reveals correlation of cavities evolution and functional motions in proteins. Nathan Desdouits , Michael Nilges , Arnaud Blondel Journal of Molecular Graphics and Modelling, 2014, 55, pp.13-24. ⟨10.1016/j.jmgm.2014.10.011⟩ Article dans une revue pasteur-01133364v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck. M. Pelosi , V. Di Bartolo , V. Mounier , D. Mège , J. M. Pascussi , et al. Journal of Biological Chemistry, 1999, 274 (20), pp.14229-37. ⟨10.1074/jbc.274.20.14229⟩ Article dans une revue hal-00138125v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor E. Laine , C. Goncalves , J. C. Karst , Aurélien Lesnard , Sylvain Rault , et al. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (25), pp.11277 - 11282. ⟨10.1073/pnas.0914611107⟩ Article dans une revue pasteur-01501815v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor Mariano Martinez , Fernando A Batista , Manon Maurel , Anthony Bouillon , Laura Ortega Varga , et al. Acta crystallographica Section D : Structural biology [1993-..], 2023, 79 (8), ⟨10.1107/s2059798323004710⟩ Article dans une revue pasteur-04158872v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Analyzing in silico the relationship between the activation of the edema factor and its interaction with calmodulin Irène Pitard , Damien Monet , Pierre L Goossens , Arnaud Blondel , Thérèse E Malliavin Frontiers in Molecular Neuroscience, 2020, ⟨10.3389/fmolb.2020.586544⟩ Article dans une revue pasteur-02999615v2	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Impact of M36I polymorphism on the interaction of HIV-1 protease with its substrates: insights from molecular dynamics. Mauricio Gs Costa , Técio G Benetti-Barbosa , Nathan Desdouits , Arnaud Blondel , Paulo M Bisch , et al. BMC Genomics, 2014, 15 (Suppl 7), pp.S5. ⟨10.1186/1471-2164-15-S7-S5⟩ Article dans une revue pasteur-01402879v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Molecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors. Elodie Laine , Leandro Martínez , Daniel Ladant , Thérèse Malliavin , Arnaud Blondel Toxins, 2012, 4, pp.580-604. ⟨10.3390/toxins4080580⟩ Article dans une revue pasteur-01459064v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors K.Y. Chen , T. Krischuns , L. Ortega Varga , E. Harigua-Souiai , S. Paisant , et al. Antiviral Research, 2022, 201, pp.105272. ⟨10.1016/j.antiviral.2022.105272⟩ Article dans une revue pasteur-03840856v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Virtual Screening in Hepatitis B Virus Drug Discovery: Current Stateof- the-Art and Future Perspectives Mohcine Elmessaoudi-Idrissi , Arnaud Blondel , Anass Kettani , Marc P Windisch , Soumaya Benjelloun , et al. Current Medicinal Chemistry, 2018, 25 (23), pp.2709-2721. ⟨10.2174/0929867325666180221141451⟩ Article dans une revue pasteur-02528562v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Identification of binding sites and favorable ligand binding moieties by virtual screening and self-organizing map analysis. Emna Harigua-Souiai , Isidro Cortes-Ciriano , Nathan Desdouits , Thérèse E Malliavin , Ikram Guizani , et al. BMC Bioinformatics, 2015, 16 (1), pp.93. ⟨10.1186/s12859-015-0518-z⟩ Article dans une revue pasteur-01144936v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus Yosser Zina Abdelkrim , Emna Harigua-Souiai , Imen Bassoumi-Jamoussi , Mourad Barhoumi , Josette Banroques , et al. Molecules, 2022, 27 (18), pp.5890. ⟨10.3390/molecules27185890⟩ Article dans une revue hal-03813436v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		The catalytic domains of C lostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid Carolina Varela Chavez , Sylviane Hoos , Georges Michel Haustant , Alexandre Chenal , Patrick England , et al. Cellular Microbiology, 2015, 17 (10), pp.1477 - 1493. ⟨10.1111/cmi.12449⟩ Article dans une revue pasteur-01400914v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		mkgridXf : Consistent Identification of Plausible Binding Sites Despite the Elusive Nature of Cavities and Grooves in Protein Dynamics Damien Monet , Nathan Desdouits , Michael Nilges , Arnaud Blondel Journal of Chemical Information and Modeling, 2019, 59 (8), pp.3506-3518. ⟨10.1021/acs.jcim.9b00103⟩ Article dans une revue pasteur-02503276v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Bacterial intracellularly active toxins: Membrane localisation of the active domain Carolina Varela-Chavez , Arnaud Blondel , Michel Popoff Cellular Microbiology, 2020, 22 (7), pp.e13213. ⟨10.1111/cmi.13213⟩ Article dans une revue pasteur-03261443v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Drug Discovery Targeting Amino Acid Racemases Paola Conti , Lucia Tamborini , Andrea Pinto , Arnaud Blondel , Paola Minoprio , et al. Chemical Reviews, 2011, 111 (11), pp.6919-6946. ⟨10.1021/cr2000702⟩ Article dans une revue pasteur-02510858v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Functional Motions Modulating VanA Ligand Binding Unraveled by Self-Organizing Maps Guillaume Bouvier , Nathalie Duclert-Savatier , Nathan Desdouits , Djalal Meziane-Cherif , Arnaud Blondel , et al. Journal of Chemical Information and Modeling, 2014, 54 (1), pp.289-301. ⟨10.1021/ci400354b⟩ Article dans une revue pasteur-02510864v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography Patricia de Aguiar Amaral , Delphine Autheman , Guilherme Dias de Melo , Nicolas Gouault , Jean-François Cupif , et al. PLoS Neglected Tropical Diseases, 2018, 12 (10), ⟨10.1371/journal.pntd.0006853⟩ Article dans une revue hal-01935360v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Activation of the Edema Factor of Bacillus anthracis by Calmodulin: Evidence of an Interplay between the EF-Calmodulin Interaction and Calcium Binding Elodie Laine , Leandro Martínez , Arnaud Blondel , Thérèse Malliavin Biophysical Journal, 2010, 99 (7), pp.2264-2272. ⟨10.1016/j.bpj.2010.07.044⟩ Article dans une revue pasteur-02510853v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation Carolina Varela Chavez , Georges Haustant , Bruno Baron , Patrick England , Alexandre Chenal , et al. Toxins, 2016, 8 (4), pp.90 - 90. ⟨10.3390/toxins8040090⟩ Article dans une revue pasteur-01406497v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Identification of Cinnamic Acid Derivatives As Novel Antagonists of the Prokaryotic Proton-Gated Ion Channel GLIC Marie S. Prevost , Sandrine Delarue-Cochin , Justine Marteaux , Claire Colas , Catherine van Renterghem , et al. Journal of Medicinal Chemistry, 2013, 56 (11), pp.4619 - 4630. ⟨10.1021/jm400374q⟩ Article dans une revue pasteur-01721702v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites Yosser Zina Abdelkrim , Emna Harigua-Souiai , Mourad Barhoumi , Josette Banroques , Arnaud Blondel , et al. Molecular and Biochemical Parasitology, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩ Article dans une revue pasteur-02528567v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A Emna Harigua-Souiai , Yosser Zina Abdelkrim , Imen Bassoumi-Jamoussi , Ons Zakraoui , Guillaume Bouvier , et al. PLoS Neglected Tropical Diseases, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩ Article dans une revue pasteur-01968424v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures. Antoine Taly , Claire Colas , Thérèse Malliavin , Arnaud Blondel , Michael Nilges , et al. Journal of Molecular Graphics and Modelling, 2011, 30, pp.100-9. ⟨10.1016/j.jmgm.2011.06.008⟩ Article dans une revue pasteur-01459822v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Mechanism of reactant and product dissociation from the anthrax edema factor: A locally enhanced sampling and steered molecular dynamics study Leandro Martínez , Thérèse Malliavin , Arnaud Blondel Proteins - Structure, Function and Bioinformatics, 2011, 79 (5), pp.1649-1661. ⟨10.1002/prot.22991⟩ Article dans une revue istex pasteur-02510854v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		An automatic tool to analyze and cluster macromolecular conformations based on self-organizing maps. Guillaume Bouvier , Nathan Desdouits , Mathias Ferber , Arnaud Blondel , Michael Nilges Bioinformatics, 2015, 31 (9), pp.1490-1492. ⟨10.1093/bioinformatics/btu849⟩ Article dans une revue pasteur-01145388v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas' disease. Armand Berneman , Lory Montout , Sophie Goyard , Nathalie Chamond , Alain Cosson , et al. PLoS ONE, 2013, 8 (4), pp.e60955. ⟨10.1371/journal.pone.0060955⟩ Article dans une revue hal-00833388v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More

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Prodrugs as new therapies against Chagas disease: In vivo synergy between Trypanosoma cruzi proline racemase inhibitors and benznidazole

Principal Component Analysis reveals correlation of cavities evolution and functional motions in proteins.

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor

3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor

Analyzing in silico the relationship between the activation of the edema factor and its interaction with calmodulin

Impact of M36I polymorphism on the interaction of HIV-1 protease with its substrates: insights from molecular dynamics.

Molecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors.

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

Virtual Screening in Hepatitis B Virus Drug Discovery: Current Stateof- the-Art and Future Perspectives

Identification of binding sites and favorable ligand binding moieties by virtual screening and self-organizing map analysis.

Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus

The catalytic domains of C lostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid

mkgridXf : Consistent Identification of Plausible Binding Sites Despite the Elusive Nature of Cavities and Grooves in Protein Dynamics

Bacterial intracellularly active toxins: Membrane localisation of the active domain

Drug Discovery Targeting Amino Acid Racemases

Functional Motions Modulating VanA Ligand Binding Unraveled by Self-Organizing Maps

Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography

Activation of the Edema Factor of Bacillus anthracis by Calmodulin: Evidence of an Interplay between the EF-Calmodulin Interaction and Calcium Binding

The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation

Identification of Cinnamic Acid Derivatives As Novel Antagonists of the Prokaryotic Proton-Gated Ion Channel GLIC

The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A

Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures.

Mechanism of reactant and product dissociation from the anthrax edema factor: A locally enhanced sampling and steered molecular dynamics study

An automatic tool to analyze and cluster macromolecular conformations based on self-organizing maps.

Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas' disease.