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Ton Motor Conformational Switch and Peptidoglycan Role in Bacterial Nutrient Uptake

 Maximilian Zinke , Maylis Lejeune , Ariel Mechaly , Benjamin Bardiaux , Ivo Gomperts Boneca , et al.
2023
Pré-publication, Document de travail hal-04235329v1
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Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

 Felipe Trajtenberg , Juan A Imelio , Matías R Machado , Nicole Larrieux , Marcelo A Marti , et al.
eLife, 2016, 5, pp.e21422. ⟨10.7554/eLife.21422⟩
Article dans une revue pasteur-02554309v1
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Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens

 Linda Grillova , Jan Oppelt , Lenka Mikalová , Markéta Nováková , Lorenzo Giacani , et al.
Frontiers in Microbiology, 2019, 10, pp.1691. ⟨10.3389/fmicb.2019.01691⟩
Article dans une revue pasteur-02547705v1
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Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake

 Maximilian Zinke , Maylis Lejeune , Ariel Mechaly , Benjamin Bardiaux , Ivo Gomperts Boneca , et al.
Nature Communications, 2024, 15, pp.331. ⟨10.1038/s41467-023-44606-z⟩
Article dans une revue hal-04378918v1
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Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira

 Haritha Adhikarla , Elsio A. Jr Wunder , Ariel E Mechaly , Sameet Mehta , Zheng Wang , et al.
Frontiers in Cellular and Infection Microbiology, 2018, 8, pp.45. ⟨10.3389/fcimb.2018.00045⟩
Article dans une revue pasteur-02100138v1
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Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish

 Alejandro Mechaly , M Oswaldo Tovar Bohórquez , Ariel E Mechaly , Eda Suku , María Rita Pérez , et al.
Frontiers in Endocrinology, 2018, 9, pp.604. ⟨10.3389/fendo.2018.00604⟩
Article dans une revue pasteur-02872241v1

Structural insights into the signalling mechanisms of two-component systems

 Françoise Jacob-Dubuisson , Ariel E Mechaly , Jean-Michel Betton , Rudy Antoine
Nature Reviews Microbiology, 2018, 16 (10), pp.585-593. ⟨10.1038/s41579-018-0055-7⟩
Article dans une revue hal-02322157v1
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Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis.

 Alexandra East , Ariel E Mechaly , Gerard H M Huysmans , Cédric Bernarde , Diana Tello-Manigne , et al.
Structure, 2016, 24 (1), pp.92-104. ⟨10.1016/j.str.2015.10.023⟩
Article dans une revue pasteur-01498343v1

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance

 Ariel E Mechaly , Ahmed Haouz , Nathalie Sassoon , Alejandro Buschiazzo , Jean-Michel Betton , et al.
Journal of Structural Biology, 2018, 204 (2), pp.165-171. ⟨10.1016/j.jsb.2018.08.001⟩
Article dans une revue hal-02322059v1

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase

 Ariel E Mechaly , Silvia Soto Diaz , Nathalie Sassoon , Alejandro Buschiazzo , Jean-Michel Betton , et al.
Structure, 2017, 25 (6), pp.939-944.e3. ⟨10.1016/j.str.2017.04.011⟩
Article dans une revue pasteur-02554313v1
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Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium

 Corentin Léger , Irène Pitard , Mirko Sadi , Nicolas Carvalho , Sébastien Brier , et al.
BMC Biology, 2022, 20 (1), pp.176. ⟨10.1186/s12915-022-01381-5⟩
Article dans une revue pasteur-03880614v1

Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis

 Fabiana San Martin , Nicole Larrieux , Ariel E Mechaly , Elsio A. Jr Wunder , Albert I Ko , et al.
Acta crystallographica Section F : Structural biology communications [2014-..], 2017, 73 (3), pp.123 - 129. ⟨10.1107/S2053230X17002096⟩
Article dans une revue pasteur-02554311v1
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An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete

 Kimberley H Gibson , Felipe Trajtenberg , Elsio A. Jr Wunder , Megan R Brady , Fabiana San Martin , et al.
eLife, 2020, 9, ⟨10.7554/eLife.53672⟩
Article dans une revue pasteur-02549761v1
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Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein

 Mariano Genera , Barbara Quioc-Salomon , Antonin Nourisson , Baptiste Colcombet-Cazenave , Ahmed Haouz , et al.
Scientific Reports, 2021, 11, pp.944. ⟨10.1038/s41598-020-79580-9⟩
Article dans une revue hal-03157335v1
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Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation

 Ariel E Mechaly , Nathalie Sassoon , Jean-Michel Betton , Pedro Alzari
PLoS Biology, 2014, 12 (1), pp.e1001776. ⟨10.1371/journal.pbio.1001776⟩
Article dans une revue pasteur-03096119v1

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis

 Ariel E Mechaly , Ahmed Haouz , Isabelle Miras , Nathalie Barilone , Patrick Weber , et al.
FEBS Letters, 2012, 586 (11), pp.1606-1611. ⟨10.1016/j.febslet.2012.04.034⟩
Article dans une revue pasteur-03137924v1
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Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins

 Yanlei Zhu , Flavio Alvarez , Nicolas Wolff , Ariel Mechaly , Sébastien Brûlé , et al.
Frontiers in Microbiology, 2022, 13, pp.829094. ⟨10.3389/fmicb.2022.829094⟩
Article dans une revue pasteur-03609684v1
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What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira.

 Derrick E Fouts , Michael A Matthias , Haritha Adhikarla , Ben Adler , Luciane Amorim-Santos , et al.
PLoS Neglected Tropical Diseases, 2016, 10 (2), pp.e0004403. ⟨10.1371/journal.pntd.0004403⟩
Article dans une revue pasteur-01436457v1

Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 ( Cys216Gly ) that causes very early onset autoimmune enteropathy

 Qing Nian , Jérémy Berthelet , Marianna Parlato , Ariel E Mechaly , Rongxing Liu , et al.
Protein Science, 2021, ⟨10.1002/pro.4246⟩
Article dans une revue pasteur-03524511v1
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Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners

 Yanlei Zhu , Florent Delhommel , Florence Cordier , Susanne Lüchow , Ariel E Mechaly , et al.
Journal of Molecular Biology, 2020, 432 (22), pp.5920 - 5937. ⟨10.1016/j.jmb.2020.09.012⟩
Article dans une revue hal-02990253v1
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Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system

 Régine Dazzoni , Yuanyuan Li , Aracelys López-Castilla , Sébastien Brier , Ariel Mechaly , et al.
Structure, 2023, ⟨10.1016/j.str.2022.12.003⟩
Article dans une revue pasteur-03932612v2
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High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur

 Patrick Weber , Cédric Pissis , Rafael Navaza , Ariel E Mechaly , Frederick Saul , et al.
Molecules, 2019, 24 (24), pp.4451. ⟨10.3390/molecules24244451⟩
Article dans une revue pasteur-02872233v1
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Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography

 Juan A Imelio , Nicole Larrieux , Ariel E Mechaly , Felipe Trajtenberg , Alejandro Buschiazzo
Bio-protocol , 2017, 7 (16), ⟨10.21769/BioProtoc.2510⟩
Article dans une revue pasteur-02872312v1
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Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker

 Yee-Wai Cheung , Pascal Röthlisberger , Ariel E Mechaly , Patrick Weber , Fabienne Levi-Acobas , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (29), pp.16790-16798. ⟨10.1073/pnas.2003267117⟩
Article dans une revue pasteur-03138380v1

Structural basis for the allosteric inhibition of UMP kinase from Gram‐positive bacteria, a promising antibacterial target

 Patrick Walter , Ariel E Mechaly , Julien Bous , Ahmed Haouz , Patrick England , et al.
FEBS Journal, 2022, 289 (16), pp.4869-4887. ⟨10.1111/febs.16393⟩
Article dans une revue pasteur-04096367v1

The c‐di‐AMP ‐binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae

 Giovanni Covaleda-Cortés , Ariel Mechaly , Terry Brissac , Heike Baehre , Laura Devaux , et al.
FEBS Journal, 2023, Accepted, unedited articles published online and citable. ⟨10.1111/febs.16724⟩
Article dans une revue pasteur-03951508v1
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High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase

 Lu Yang , Tristan Wagner , Ariel Mechaly , Alexandra Boyko , Eduardo Bruch , et al.
Nature Communications, 2023, 14 (1), pp.4851. ⟨10.1038/s41467-023-40253-6⟩
Article dans une revue pasteur-04184138v1
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Allosteric Activation of Bacterial Response Regulators: the Role of the Cognate Histidine Kinase Beyond Phosphorylation

 Felipe Trajtenberg , Daniela Albanesi , Natalia Ruétalo , Horacio Botti , Ariel E Mechaly , et al.
mBio, 2014, 5 (6), pp.e02105. ⟨10.1128/mBio.02105-14⟩
Article dans une revue pasteur-02554121v1
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A High‐Affinity Calmodulin‐Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells

 Alexis Voegele , Mirko Sadi , Darragh Patrick O'Brien , Pauline Gehan , Dorothée Raoux‐barbot , et al.
Advanced Science, 2021, pp.2003630. ⟨10.1002/advs.202003630⟩
Article dans une revue pasteur-03211832v1
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