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Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity
Louis S. Ates
,
Anzaan Dippenaar
,
Fadel Sayes
,
Alexandre Pawlik
,
Christiane Bouchier
,
et al.
Article dans une revue
hal-01884644v1
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Lsr2 Is an Important Determinant of Intracellular Growth and Virulence in Mycobacterium abscessus
Vincent Le Moigne
,
Audrey Bernut
,
Mélanie Cortes
,
Albertus Viljoen
,
Christian Dupont
,
et al.
Article dans une revue
pasteur-02618218v1
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Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria
Eva C. Boritsch
,
Varun Khanna
,
Alexandre Pawlik
,
Nadine Honoré
,
Victor Navas
,
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (35), pp.9876-9881. ⟨10.1073/pnas.1604921113⟩
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pasteur-02618520v1
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Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator
J. Gonzalo-Asensio
,
W. Malaga
,
Alexandre Pawlik
,
Catherine Astarie-Dequeker
,
C. Passemar
,
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (31), pp.11491-11496. ⟨10.1073/pnas.1406693111⟩
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Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus
Alexandre Pawlik
,
Guillaume Garnier
,
Mickael Orgeur
,
Pin Tong
,
Amanda Lohan
,
et al.
Article dans une revue
pasteur-02618774v1
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A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity
Jodie Lopez
,
François Anna
,
Pierre Authié
,
Alexandre Pawlik
,
Min-Wen Ku
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et al.
Article dans une revue
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Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin αIIb-expressing cells
Béatrice Jacquelin
,
Thierry Kortulewski
,
Pierre Vaigot
,
Alexandre Pawlik
,
Gaëtan Gruel
,
et al.
Article dans une revue
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Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis
Philip Supply
,
Michael Marceau
,
Sophie Mangenot
,
David Roche
,
Carine Rouanet
,
et al.
Article dans une revue
pasteur-02615220v1
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A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component
Luis Solans
,
Nacho Aguiló
,
Sofia Samper
,
Alexandre Pawlik
,
Wafa Frigui
,
et al.
Article dans une revue
pasteur-02618736v1
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From environmental bacteria to obligate human pathogen: adaptations associated with the emergence of tuberculosis bacilli
Delphine Payros
,
Wladimir Malaga
,
Alexandre Pawlik
,
Serge Mazères
,
Céline Berrone
,
et al.
EMBO Workshop. Pathogen immunity and signalling., Apr 2019, Oxford, United Kingdom
Communication dans un congrès
hal-02341937v1
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Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages
Violaine Dubois
,
Alexandre Pawlik
,
Anouchka Bories
,
Vincent Le Moigne
,
Odile Sismeiro
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et al.
Article dans une revue
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Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
Violaine Dubois
,
Laura Laencina
,
Anouchka Bories
,
Vincent Le Moigne
,
Alexandre Pawlik
,
et al.
Journal of visualized experiments : JoVE, 2018, 139, pp.57766. ⟨10.3791/57766⟩
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Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection.
Matthias I Gröschel
,
Fadel Sayes
,
Sung Jae Shin
,
Wafa Frigui
,
Alexandre Pawlik
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et al.
Article dans une revue
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Changes in transcriptome after in vivo exposure to ionising radiation reveal a highly specialised liver response
Alexandre Pawlik
,
Paul Delmar
,
Sebastien Bosse
,
Laurie Sainz
,
Cyrille Petat
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et al.
Article dans une revue
pasteur-02618874v1
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A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus
Christian Dupont
,
Albertus Viljoen
,
Faustine Dubar
,
Mickaël Blaise
,
Audrey Bernut
,
et al.
Article dans une revue
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The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis
Nawel Slama
,
Stevie Jamet
,
Wafa Frigui
,
Alexandre Pawlik
,
Daria Bottai
,
et al.
Article dans une revue
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De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis
Thomas Laval
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Laura Pedró-Cos
,
Wladimir Malaga
,
Laure Guenin-Macé
,
Alexandre Pawlik
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et al.
Article dans une revue
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Transcriptome Characterization Uncovers the Molecular Response of Hematopoietic Cells to Ionizing Radiation
Alexandre Pawlik
,
Olivier Alibert
,
Sylvain Baulande
,
Pierre Vaigot
,
Diana Tronik-Le Roux
Article dans une revue
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CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection
Fadel Sayes
,
Alexandre Pawlik
,
Wafa Frigui
,
Matthias I Gröschel
,
Samuel Crommelynck
,
et al.
Article dans une revue
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Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis
Fabien Le Chevalier
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Alessandro Cascioferro
,
Wafa Frigui
,
Alexandre Pawlik
,
Eva C. Boritsch
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et al.
Article dans une revue
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Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis
Laleh Majlessi
,
Fadel Sayes
,
Jean-François Bureau
,
Alexandre Pawlik
,
Valérie Michel
,
et al.
Article dans une revue
hal-01652031v1
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Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants
Anne-Laure Roux
,
Aurélie Ray
,
Alexandre Pawlik
,
Halima Medjahed
,
Gilles Etienne
,
et al.
Article dans une revue
pasteur-02618829v1
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Novel Microarray-Based Method for Estimating Exposure to Ionizing Radiation
Gaëtan Gruel
,
Carlo Lucchesi
,
Alexandre Pawlik
,
Vincent Frouin
,
Olivier Alibert
,
et al.
Article dans une revue
pasteur-02618889v1
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Pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence
Eva C. Boritsch
,
Wafa Frigui
,
Alessandro Cascioferro
,
Wladimir Malaga
,
Gilles Etienne
,
et al.
Article dans une revue
pasteur-01265519v1
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Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli
Aideen C Allen
,
Wladimir Malaga
,
Cyril Gaudin
,
Arnaud Volle
,
Flavie Moreau
,
et al.
Article dans une revue
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Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts
Mickael Orgeur
,
Wafa Frigui
,
Alexandre Pawlik
,
Simon Clark
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Ann Williams
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et al.
Article dans une revue
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TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages
Daria Bottai
,
Wafa Frigui
,
Fadel Sayes
,
Mariagrazia Di Luca
,
Dalila Spadoni
,
et al.
Article dans une revue
pasteur-02473990v1
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