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Anne Spasojevic - de Biré

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Identifiants chercheurs

Présentation

She obtained a degree in chemistry at the University Pierre and Marie Curie, Paris VI in 1985. She went on to complete a Ph.D. on the study of the electron deformation density of carbyne chromium complexes in 1989. This was followed by a postdoctoral period at the Laboratoire Léon Brillouin at the CEA Saclay on polarized neutron diffraction on superconductor compounds. After this, she got a permanent position at Ecole Centrale Paris (ECP as merged with Supelec in 1rst January 2015 and is called now CentraleSupelec) as a teaching researcher. She is currently a full professor in the same institution. During the first 20 years, her research activity was mainly based on the experimental determination of the electron and electrostatic properties of molecules of pharmaceutical interest. The high-resolution X-ray diffraction on single crystal method used in her research allows getting a better understanding of the interaction drug – biological target or drug - excipient. The different classes of compounds studied are AINS (aspirin) and anti-leukemic agents (busulfan, cephalotaxine). From a chemical point of view, she has concentrated her efforts on thiosemicarbazide complexes and polyoxovanadates compounds. Last 10 years, she has developed a new nucleation method induced by polarized laser (NPLIN) leading to crystallization control (polymorphism and crystalline quality). This method has been supported through an ANR project between 4 French laboratories she coordinates (490 000 €). She has also got financial support for this method from Institut d’Alembert (ENS Cachan), Cristech (French network on crystallization) Prestige (EU-fund), and CHARMMAT (French laboratories network). She has also obtained in the past, international support programs with Serbia (Pavle Savic and CNRS-MSR). She is scientifically responsible for CentraleSupelec in the CHARMMMAT Labex. She is currently the supervisor of 1 post-doc. Her teaching activity at Ecole Centrale Paris (one of best engineering curricula in France) is mainly focused on the development of new pedagogical methods dedicated to developing students’ skills in project methodology (teamwork, problem-solving, project management…) and to the development of personal skills (communication, leadership, innovation, entrepreneurship, coaching…). She has been co-responsible for the project activity at ECP (1 seminar of 3.5 days, 10\*7 conferences of 1h30, 100 projects, 40 company clients, 1 team of 15 teachers, and about 500 1st year students in ECP). She is now hardly involved in the creation of a new engineer CentraleSupelec curricula for 800 students per year which have begun in September 2018. In the CentraleSupelec curricula she is involved in the APP (Atelier Projet Professionnel) and API (Atelier Pratiques Ingénieur) activities in the management team and as a teacher (animateur) in the 1st and 2nd year. She has developed a delocalized master's degree program in industrial engineering at Belgrade (Serbia) and has been responsible for the project activity (Bachelor project) at Ecole Centrale Pékin, a french-Chinese institution at BeiHang University since November 2008. From 15 May 2012, and for 3 years, she has been Dean of Studies and vice director of Ecole Centrale Pékin. She is actually responsible for the Professor’s school for the abroad campuses (in China, India, Morocco, and Mauritius). She has developed a strong collaboration with Vinca Institute, Faculty of Mining and Geology, Faculty of Physical Chemistry, Faculty of Medicine since 1995 leading to 2/3 of her papers with Serbian researchers. To date, her scientific production can be broken down as follows: 63 articles divided into:1 article in a collective work (O), 50 publications (P) in international peer-reviewed journals referenced in a web of science (Inorg. Chem., Crystal Growth, J. Phys. Chem.), 10 conference proceedings (A), 2 popularization articles (V); 174 conference participations in 24 conferences invited (I), 142 oral or poster communications (C) and 8 invited seminars (S). Her papers have led to 896 citations and an h-factor of 16. I supervised the work of 11 Ph.D. students (1 drop out for reasons medical). She has been the President of the teachers association of the Ecole Centrale Paris. She has been an elective member of the board of ECP, and a regular member of the ECPk board. She has been named “Chevalier” of “Palmes Académiques” in September 2009 and “officier” in September 2016. She has received an award for an outstanding contribution at ECPk from the Chinese First Ministry Ms. LIU Yandong and the French Ministery of International affairs Mr. Laurent Fabius in Beijing (15 May 2015). She has four children and three grant-children.

Publications

jean-michel-gillet
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Experimental and theoretical insights of functionalized hexavanadates on Na+/K+-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays

Nada B Bošnjaković-Pavlović , Xiao Xu , Danijela Krstić , Jean-Michel Gillet , Yongge B Wei
Journal of Inorganic Biochemistry, 2019, 198, pp.110720. ⟨10.1016/j.jinorgbio.2019.110720⟩
Article dans une revue hal-02163805v1
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Reactivity of 12-tungstophosphoric acid and its inhibitor potency toward Na + /K + -ATPase: A combined 31 P NMR study, ab initio calculations and crystallographic analysis

Nada Bošnjaković-Pavlović , Danica Bajuk-Bogdanović , Joanna Zakrzewska , Zeyin Yan , Ivanka Holclajtner-Antunović
Journal of Inorganic Biochemistry, 2017, 176, pp.90-99. ⟨10.1016/j.jinorgbio.2017.08.014⟩
Article dans une revue hal-01592050v1
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Non-Photochemical Laser-Induced Nucleation of Sulfathiazole in a Water/Ethanol Mixture

Wenjing Li , Aziza Ikni , Philippe Scouflaire , Xiaoxuan Shi , Nouha El Hassan
Crystal Growth & Design, 2016, 16 (5), pp.2514 - 2526. ⟨10.1021/acs.cgd.5b01526⟩
Article dans une revue hal-01380123v1
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A combined crystallographic analysis and ab initio calculations to interpret the reactivity of functionalized hexavanadates and their inhibitor potency toward Na+/K+-ATPase

Xiao M Xu , Nada B Bošnjaković-Pavlović , Mirjana M Čolović , Danijela M Krstić , Vesna M Vasić
Journal of Inorganic Biochemistry, 2016, 161, pp.27 - 36. ⟨10.1016/j.jinorgbio.2016.04.029⟩
Article dans une revue hal-01385048v1
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Experimental Demonstration of the Carbamazepine Crystallization from Non-photochemical Laser-Induced Nucleation in Acetonitrile and Methanol

Aziza Ikni , Bertrand Clair , Philippe Scouflaire , S. Veesler , J.M. Gillet
Crystal Growth & Design, 2014, 14 (7), pp.3286-3299. ⟨10.1021/cg500163c⟩
Article dans une revue hal-01053346v1
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Electron Properties of Carbamazepine Drug in Form III

Nouha El Hassan , Aziza Ikni , Jean-Michel Gillet , Anne Spasojevic-de Bire , Nour Eddine Ghermani
Crystal Growth & Design, 2013, 13 (7), pp.2887-2896. ⟨10.1021/cg4002994⟩
Article dans une revue hal-02270731v1

Non Photochemical Laser-Induced Nucleation: past, present and future

Anne Spasojevic - de Biré , Philippe Scouflaire , Z Zhang , Wenjing Li , Aziza Ikni
Serbian Crystallographic Meeting, Jun 2017, Vrsac, Serbia
Communication dans un congrès hal-02305629v1

New insight in the Non Photochemical Laser-Induced Nucleation mechanism. An experimental and theoretical combined approach

Anne Spasojevic - de Biré , Aziza Ikni , Wenjing Li , Bertrand Clair , Z Zhang
CRISTECH, Oct 2016, Autrans, France
Communication dans un congrès hal-02305626v1

Non-Photochemical LASER-Induced Nucleation in Water/Ethanol of sulfathiazole

Wenjing Li , Aziza Ikni , Philippe Scouflaire , Xiaoxuan Shi , Nouha El Hassan
ECG5, Sep 2015, Bologne, Italy
Communication dans un congrès hal-02298856v1

Non-Photochemical LASER-Induced Nucleation in Water/Ethanol of sulfathiazole

Wenjing Li , Aziza Ikni , Philippe Scouflaire , Xiaoxuan Shi , Nouha El Hassan
3èmes Journées Charmmmat, Jul 2015, Orsay, France
Communication dans un congrès hal-02298831v1

Contribution to the understanding of the putative NPLIN polarization switching mechanism through crystalization of carbamazepine, sulfathiazole and glycine

Anne Spasojevic - de Biré , Aziza Ikni , W. Li , Bertrand Clair , Philippe Scouflaire
International Symposium on Industrial Crystallization - ISIC 19, Sep 2014, Toulouse, France
Communication dans un congrès hal-02298976v1

Experimental demonstration of the carbamazepine crystallization from Non-Photochemical LASER Induced Nucleation in acetonitrile and méthanol

Aziza Ikni , Bertrand Clair , Philippe Scouflaire , Stéphane Veesler , Jean-Michel Gillet
E-MRS 2014 SPRING MEETING, May 2014, Lille, France
Communication dans un congrès hal-02298983v1
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From photochemical and non-photochemical nucleation induced by LASER to experimental and theoretical interaction energy determination: Carbamazepine III a complete study

Anne Spasojevic - de Biré , Aziza Ikni , Nouha El Hassan , Bertrand Clair , Philippe Scouflaire
Serbian Crystallographic Meeting, Jun 2013, Beograd, Serbia
Communication dans un congrès hal-02302658v1

Experimental and Theoretical Charge Density Study of a Functionalized Hexavanadate

Xiao Xu , Nada Bošnjaković-Pavlović , Sladjana Novakovic , Jean-Michel Gillet , Yongge B Wei
Serbian Crystallographic Meeting, Jun 2013, Beograd, Serbia
Communication dans un congrès hal-02302661v1

Propriétés électrostatiques de molécules d’intérêt pharmaceutique

Nour-Eddine Ghermani , Nouha El Hassan , Aziza Ikni , Xiaoxuan Shi , Jean-Michel Gillet
AFC, Jul 2013, Bordeaux, France
Communication dans un congrès hal-02302664v1

High resolution crystallography of small molecules: Is it the future of pharmaceutical research ?

Nour-Eddine Ghermani , Nouha El Hassan , Jean-Michel Gillet , Nicolas Guiblin , Anne Spasojevic - de Biré
20th SC-XRD Users‘ Meeting, Sep 2012, Bad Herrenalb, Germany
Communication dans un congrès hal-02302612v1

Electron Properties of pharmaceutical molecules

Nour-Eddine Ghermani , Nouha El Hassan , Jean-Michel Gillet , Nicolas Guiblin , Anne Spasojevic - de Biré
European Crystallographic Meeting, ECM 27, Aug 2012, Bergen, Norway. pp.s54 s54
Communication dans un congrès hal-02302593v1

High resolution X-ray diffraction, ab initio calculations and thermodynamic measurements to gain insight on the polymorphism of drugs. Application to piracetam

Nouha El Hassan , Anne Spasojevic - de Biré , Jean-Michel Gillet , Nour-Eddine Ghermani , Philippe Espeau
Serbian Crystallographic Meeting, May 2012, Bela Crkva, Serbia. pp.558 - 568
Communication dans un congrès hal-02301176v1

Are electrostatic properties pertinent to discriminate the activity of some derivatives quinolines as HIV-1 integrase inhibitor ? : an ab initio study

Blandine Courcot , Anne Spasojevic - de Biré , Jean-Michel Gillet , D. Desmaële , Fatima Zouhiri
5th World Meeting on Pharmaceutics Biopharmaceutics and Pharmaceutical Technology, Mar 2006, Geneva, Switzerland
Communication dans un congrès hal-02304712v1

Electrostatic properties of two precursors of potent HIV-1 integrase inhibitors

Delphine Firley , Blandine Courcot , Jean-Michel Gillet , Anne Spasojevic - de Biré , Bernard Fraisse
XX IUCR, Aug 2005, Florence, Italy. pp.c277 c277, ⟨10.1107/S0108767305088203⟩
Communication dans un congrès hal-02304690v1

Predicting electronic properties and behaviour of pharmaceutical compounds in their environment

Blandine Courcot , Delphine Firley , Anne Spasojevic - de Biré , Jean-Michel Gillet , Nour-Eddine Ghermani
XVI International school on the physics and chemistry of condensed matter : Structural aspects of solids, Jul 2004, Białowieża, Poland
Communication dans un congrès hal-02304564v1

Experimental and theoretical electron density and electrostatic properties as a tool for understanding activity of HIV-1 integrase inhibitor precursors

Delphine Firley , Blandine Courcot , Anne Spasojevic - de Biré , Jean-Michel Gillet , B. Fraisse
XXII European Crystallographic Meeting, Aug 2004, Budapest, Hungary. ⟨10.1107/S0108767304099398⟩
Communication dans un congrès hal-02304573v1