Anne Houdusse

Documents

Publications

	Cryo-EM structure of the folded-back state of human β-cardiac myosin Alessandro Grinzato , Daniel Auguin , Carlos Kikuti , Neha Nandwani , Dihia Moussaoui Nature Communications, 2023, 14 (1), pp.3166. ⟨10.1038/s41467-023-38698-w⟩ Article dans une revue hal-04267665v1
	How myosin VI traps its off-state, is activated and dimerizes Louise Canon , Vicente Planelles-Herrero , Young Il Lee , Franck Mayeux , Tianming Lin Nature Communications, 2023, 14 (1), pp.6732. ⟨10.1038/s41467-023-42376-2⟩ Article dans une revue hal-04293608v1
	The many roles of myosins in filopodia, microvilli and stereocilia Anne Houdusse , Margaret A Titus Current Biology - CB, 2021, 31 (10), pp.R586-R602. ⟨10.1016/j.cub.2021.04.005⟩ Article dans une revue hal-03281243v1
	Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth Lara Katharina Krüger , Matthieu Gélin , Liang Ji , Carlos Kikuti , Anne Houdusse eLife, 2021, 10, pp.e67489. ⟨10.7554/eLife.67489⟩ Article dans une revue hal-03258505v1
	VASP-mediated actin dynamics activate and recruit a filopodia myosin Ashley L Arthur , Amy Crawford , Anne Houdusse , Margaret A Titus eLife, 2021, 10, ⟨10.7554/elife.68082⟩ Article dans une revue hal-03395283v1
	Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance Catalina Lodillinsky , Laetitia Fuhrmann , Marie Irondelle , Olena Pylypenko , Xiao-Yan Li Oncogene, inPress, ⟨10.1038/s41388-021-01826-1⟩ Article dans une revue hal-03238972v1
	Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures Constanze Erdmann , Roua Hassoun , Sebastian Schmitt , Carlos Kikuti , Anne Houdusse Antioxidants , 2021, 10 (7), pp.1082. ⟨10.3390/antiox10071082⟩ Article dans une revue hal-03453111v1
	Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance Catalina Lodillinsky , Laetitia Fuhrmann , Marie Irondelle , Olena Pylypenko , Xiao-Yan Li Oncogene, 2021, 40 (23), pp.4019 - 4032. ⟨10.1038/s41388-021-01826-1⟩ Article dans une revue hal-03453132v1
	The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity Julien Robert-Paganin , Xiao-Ping Xu , Mark Swift , Daniel Auguin , James Robblee Nature Communications, 2021, 12 (1), pp.1892. ⟨10.1038/s41467-021-22093-4⟩ Article dans une revue hal-03453769v1
	Biological nanomotors, driving forces of life Anne Houdusse Comptes Rendus. Biologies, 2021, 343 (4), pp.53-78. ⟨10.5802/crbiol.45>⟩ Article dans une revue hal-03453097v1
	Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth Lara Katharina Krüger , Matthieu Gélin , Liang Ji , Carlos Kikuti , Anne Houdusse eLife, 2021, 10, ⟨10.7554/eLife.67489⟩ Article dans une revue hal-03453181v1
	Force Generation by Myosin Motors: A Structural Perspective Julien Robert-Paganin , Olena Pylypenko , Carlos Kikuti , H. Lee Sweeney , Anne Houdusse Chemical Reviews, 2020, 120 (1), pp.5-35. ⟨10.1021/acs.chemrev.9b00264⟩ Article dans une revue hal-03238440v1
	Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets Dihia Moussaoui , James P Robblee , Daniel Auguin , Elena B Krementsova , Silvia Haase eLife, 2020, 9, pp.e60581. ⟨10.7554/elife.60581⟩ Article dans une revue hal-03059341v1
	Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness Máté Gyimesi , Ádám Horváth , Demeter Túrós , Sharad Kumar Suthar , Máté Pénzes Cell, 2020, 183 (2), pp.335-346.e13. ⟨10.1016/j.cell.2020.08.050⟩ Article dans une revue hal-03453772v1
	2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology Marco Lucchino , Anne Billet , Antoine Versini , Harikrishna Bavireddi , Bhanu-Das Dasari ChemBioChem, 2019, 20 (7), pp.968-973. ⟨10.1002/cbic.201900092⟩ Article dans une revue hal-02324665v1
	Optimized filopodia formation requires myosin tail domain cooperation Ashley Arthur , Livia Songster , Helena Sirkia , Akash Bhattacharya , Carlos Kikuti Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (44), pp.22196-22204. ⟨10.1073/pnas.1901527116⟩ Article dans une revue hal-02349330v1
	Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism Julien Robert-Paganin , James Robblee , Daniel Auguin , Thomas Blake , Carol Bookwalter Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11120-0⟩ Article dans une revue hal-02349247v1
	Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism Julien Robert-Paganin , James P Robblee , Daniel Auguin , Thomas C A Blake , Carol S Bookwalter Nature Communications, 2019, 10, ⟨10.1038/s41467-019-11120-0⟩ Article dans une revue hal-03059356v1
	MYO5B , STX3 , and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update Herschel Dhekne , Olena Pylypenko , Arend Overeem , Rosaria Ferreira , K. Joeri van Der Velde Human Mutation, 2018, 39 (3), pp.333-344. ⟨10.1002/humu.23386⟩ Article dans une revue hal-02349537v1
	Myosin VI and branched actin filaments mediate membrane constriction and fission of melanosomal tubule carriers Léa Ripoll , Xavier Heiligenstein , Ilse Hurbain , Lia Domingues , Florent Figon Journal of Cell Biology, 2018, 217 (8), pp.2709 - 2726. ⟨10.1083/jcb.201709055⟩ Article dans une revue hal-03059386v1
	An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics Florian Blanc , Tatiana Isabet , Hannah Benisty , H. Lee Sweeney , Marco Cecchini Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (24), pp.6213-6218. ⟨10.1073/pnas.1711512115⟩ Article dans une revue hal-02349286v1
	Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition Julien Robert-Paganin , Daniel Auguin , Anne Houdusse Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06191-4⟩ Article dans une revue hal-02349257v1
	Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition Julien Robert-Paganin , Daniel Auguin , Anne Houdusse Nature Communications, 2018, 9, ⟨10.1038/s41467-018-06191-4⟩ Article dans une revue hal-03059371v1
	Circularly permuted fluorogenic proteins for the design of modular biosensors Alison G Tebo , Frederico M Pimenta , Martha Zoumpoulaki , Carlos Kikuti , Helena Sirkia ACS Chemical Biology, 2018, 13 (9), pp.2392 - 2397. ⟨10.1021/acschembio.8b00417⟩ Article dans une revue hal-01909679v1
	The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry Joseph Atherton , I-Mei Yu , Alexander Cook , Joseph M Muretta , Agnel Joseph eLife, 2017, 6, ⟨10.7554/eLife.27793⟩ Article dans une revue hal-04015847v1
	Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions Stephanie Miserey-Lenkei , Hugo Bousquet , Olena Pylypenko , Sabine Bardin , Ariane Dimitrov Nature Communications, 2017, 8 (1), pp.1254. ⟨10.1038/s41467-017-01266-0⟩ Article dans une revue hal-02349571v1
	Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity Olena Pylypenko , Hussein Hammich , I-Mei Yu , Anne Houdusse Small GTPases, 2017, 9 (1-2), pp.22-48. ⟨10.1080/21541248.2017.1336191⟩ Article dans une revue hal-02349559v1
	Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex Sara Bizzotto , Ana Uzquiano , Florent Dingli , Dmitry Ershov , Anne Houllier Scientific Reports, 2017, 7 (1), pp.17308. ⟨10.1038/s41598-017-15253-4⟩ Article dans une revue hal-03825519v1
	Oxidation of F-actin controls the terminal steps of cytokinesis Stéphane Frémont , Hussein Hammich , Jian Bai , Hugo Wioland , Kerstin Klinkert Nature Communications, 2017, 8, pp.1-16. ⟨10.1038/ncomms14528⟩ Article dans une revue hal-01492528v1
	Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil Vicente J Planelles-Herrero , James J Hartman , Julien Robert-Paganin , Fady I Malik , Anne Houdusse Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-00176-5⟩ Article dans une revue hal-03059358v1
	Myosin 7 and its adaptors link cadherins to actin I-Mei Yu , Vicente J Planelles-Herrero , Yannick Sourigues , Dihia Moussaoui , Helena Sirkia Nature Communications, 2017, 8, pp.15864. ⟨10.1038/ncomms15864⟩ Article dans une revue hal-01984704v1
	The myosin X motor is optimized for movement on actin bundles Virginie Ropars , Zhaohui Yang , Tatiana Isabet , Florian Blanc , Kaifeng Zhou Nature Communications, 2016, 7, pp.12456. ⟨10.1038/ncomms12456⟩ Article dans une revue hal-01361523v1
	Force-producing ADP state of myosin bound to actin Sarah Wulf , Virginie Ropars , Setsuko Fujita-Becker , Marco Oster , Goetz Hofhaus Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (13), pp.E1844-E1852. ⟨10.1073/pnas.1516598113⟩ Article dans une revue hal-02349597v1
	Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes Olena Pylypenko , Tobias Welz , Janine Tittel , Martin Kollmar , Florian Chardon eLife, 2016, 5, pp.e17523. ⟨10.7554/eLife.17523⟩ Article dans une revue hal-02349587v1
	Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening. Kerstin Klinkert , Murielle Rocancourt , Anne Houdusse , Arnaud Echard Nature Communications, 2016, 7, pp.11166. ⟨10.1038/ncomms11166⟩ Article dans une revue pasteur-01301777v1
	How Actin Initiates the Motor Activity of Myosin Paola Llinas , Tatiana Isabet , Lin Song , Virginie Ropars , Bin Zong Developmental Cell, 2015, 33, pp.401 - 412. ⟨10.1016/j.devcel.2015.03.025⟩ Article dans une revue hal-03059350v1
	Myosin VI deafness mutation prevents the initiation of processive runs on actin Olena Pylypenko , Lin Song , Ai Shima , Zhaohui Yang , Anne Houdusse Proceedings of the National Academy of Sciences of the United States of America, 2015, 112, pp.E1201 - E1209. ⟨10.1073/pnas.1420989112⟩ Article dans une revue hal-03059375v1
	How actin initiates the motor activity of Myosin. Paola Llinas , Tatiana Isabet , Lin Song , Virginie Ropars , Bin Zong Developmental Cell, 2015, 33 (4), pp.401-12. ⟨10.1016/j.devcel.2015.03.025⟩ Article dans une revue hal-01447817v1
	Myosin VI deafness mutation prevents the initiation of processive runs on actin Olena Pylypenko , Lin Song , Ai Shima , Zhaohui Yang , Anne Houdusse Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (11), pp.E1201-E1209. ⟨10.1073/pnas.1420989112⟩ Article dans une revue hal-02349599v1
	Structural basis of myosin V Rab GTPase-dependent cargo recognition Olena Pylypenko , Wikayatou Attanda , Charles Gauquelin , Marion Lahmani , Doudouh Coulibaly Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (51), pp.20443 - 20448. ⟨10.1073/pnas.1314329110⟩ Article dans une revue pasteur-03525520v1
	Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI Julie Ménétrey , Tatiana Isabet , Virginie Ropars , Monalisa Mukherjea , Olena Pylypenko Molecular Cell, 2012, 48 (1), pp.75-86. ⟨10.1016/j.molcel.2012.07.034⟩ Article dans une revue hal-02349630v1
	How myosin motors power cellular functions - an exciting journey from structure to function Paola Llinas , Olena Pylypenko , Tatiana Isabet , Monalisa Mukherjea , H. Lee Sweeney FEBS Journal, 2012, 279 (4), pp.551-562. ⟨10.1111/j.1742-4658.2011.08449.x⟩ Article dans une revue hal-02349656v1
	Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI Julie Ménétrey , Tatiana Isabet , Virginie Ropars , Monalisa Mukherjea , Olena Pylypenko Molecular Cell, 2012, 48 (1), pp.75 - 86. ⟨10.1016/j.molcel.2012.07.034⟩ Article dans une revue hal-03059379v1
	Essential "ankle" in the myosin lever arm O. Pylypenko , A. Houdusse Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (1), pp.5-6. ⟨10.1073/pnas.1017676108⟩ Article dans une revue hal-02349672v1
	Role of Insert-1 of Myosin VI in Modulating Nucleotide Affinity Olena Pylypenko , Lin Song , Gaelle Squires , Xiaoyan Liu , Alan B Zong Journal of Biological Chemistry, 2011, 286 (13), pp.11716 - 11723. ⟨10.1074/jbc.m110.200626⟩ Article dans une revue hal-03059381v1
	Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids Amel Bahloul , Vincent Michel , Jean-Pierre Hardelin , Sylvie Nouaille , Sylviane Hoos Human Molecular Genetics, 2010, 19 (18), pp.3557 - 3565. ⟨10.1093/hmg/ddq271⟩ Article dans une revue pasteur-03525648v1
	The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4. Tatiana Isabet , Guillaume Montagnac , Karine Regazzoni , Bertrand Raynal , Fatima El Khadali EMBO Journal, 2009, 28 (18), pp.2687 - 2858. ⟨10.1038/emboj.2009.209⟩ Article dans une revue hal-00416785v1
	Structural Basis for Recruitment of Rab6-Interacting Protein 1 to Golgi via a RUN Domain. Rosario Recacha , Annick Boulet , Florence Jollivet , Solange Monier , Anne Houdusse Structure / Struct Fold Des; Structure (Camb ), 2009, 17 (1), pp.21-30. ⟨10.1016/j.str.2008.10.014⟩ Article dans une revue inserm-00355625v1
	Electrospray ionization mass spectrometry studies of noncovalent myosin VI complexes reveal a new specific calmodulin binding site Guillaume Chevreux , Noelle Potier , Alain Dorsselaer , Amel Bahloul , Anne Houdusse Journal of The American Society for Mass Spectrometry, 2005, 16 (8), pp.1367-1376. ⟨10.1016/j.jasms.2005.03.023⟩ Article dans une revue hal-02981194v1
	The unique insert in myosin VI is a structural calcium-calmodulin binding site A. Bahloul , G. Chevreux , A. Wells , Davy Martin , J. Nolt Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (14), pp.4787-4792. ⟨10.1073/pnas.0306892101⟩ Article dans une revue hal-02981195v1
	Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients Gaël Ménasché , Jérôme Feldmann , Anne Houdusse , Catherine Desaymard , Alain Fischer Blood, 2003, 101, pp.2736 - 2742. ⟨10.1182/blood-2002-09-2789⟩ Article dans une revue hal-03059374v1
	Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1) Gaël Ménasché , Chen Hsuan Ho , Ozden Sanal , Jerome Feldmann , Ilhan Tezcan Journal of Clinical Investigation, 2003, 112 (3), pp.450-456. ⟨10.1172/JCI18264⟩ Article dans une revue inserm-02440362v1
	Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients Gaël Ménasché , Jerome Feldmann , Anne Houdusse , Catherine Desaymard , Alain Fischer Blood, 2003, 101 (7), pp.2736-2742. ⟨10.1182/blood-2002-09-2789⟩ Article dans une revue inserm-02440369v1
	Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex. Véronique Chitarra , Pedro M. Alzari , Graham A. Bentley , T. Narayana Bhat , Jean-Luc Eiselé Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 (16), pp.7711-7715. ⟨10.1073/pnas.90.16.7711⟩ Article dans une revue pasteur-03136514v1
	Three-dimensional structure and antigen binding specificity of antibodies D. Tello , S. Spinelli , H. Souchon , F.A. Saul , M.M. Riottot Biochimie, 1990, 72 (8), pp.507-512. ⟨10.1016/0300-9084(90)90114-v⟩ Article dans une revue pasteur-03136462v1

	Myosin Structures. H Lee Sweeney , Anne Houdusse , Julien Robert-Paganin , H. Lee Sweeney Myosins - A Superfamily of Molecular Motors, 1239, pp.7-19, 2020, ⟨10.1007/978-3-030-38062-5_2⟩ Chapitre d'ouvrage hal-03053363v1

	Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design Dihia Moussaoui , James Robblee , Daniel Auguin , Fabio Fisher , Patricia Fagnant 2022 Pré-publication, Document de travail hal-03811821v1
	Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6 Fanomezana Moutse Ranaivoson , Vincent Crozet , Matthieu P.M.H. Benoît , Amna Abdalla Mohammed Khalid , Carlos Kikuti 2022 Pré-publication, Document de travail hal-03872652v1
	Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition Julien Robert-Paganin , Daniel Auguin , Anne Houdusse 2020 Pré-publication, Document de travail hal-03053365v1
	Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis Dihia Moussaoui , James P Robblee , Daniel Auguin , Elena B Krementsova , Silvia Haase 2020 Pré-publication, Document de travail hal-03059395v1
	Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis Dihia Moussaoui , James Robblee , Daniel Auguin , Elena Krementsova , Silvia Haase 2020 Pré-publication, Document de travail hal-03053364v1
	Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition Julien Robert-Paganin , Daniel Auguin , Anne Houdusse 2020 Pré-publication, Document de travail hal-03059367v1
	Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis Dihia Moussaoui , James P Robblee , Daniel Auguin , Elena B Krementsova , Silvia Haase 2020 Pré-publication, Document de travail hal-03059369v1

Anne Houdusse

Publications

Cryo-EM structure of the folded-back state of human β-cardiac myosin

How myosin VI traps its off-state, is activated and dimerizes

The many roles of myosins in filopodia, microvilli and stereocilia

Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

VASP-mediated actin dynamics activate and recruit a filopodia myosin

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity

Biological nanomotors, driving forces of life

Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

Force Generation by Myosin Motors: A Structural Perspective

Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology

Optimized filopodia formation requires myosin tail domain cooperation

Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism

Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism

MYO5B , STX3 , and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update

Myosin VI and branched actin filaments mediate membrane constriction and fission of melanosomal tubule carriers

An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Circularly permuted fluorogenic proteins for the design of modular biosensors

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions

Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex

Oxidation of F-actin controls the terminal steps of cytokinesis

Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

Myosin 7 and its adaptors link cadherins to actin

The myosin X motor is optimized for movement on actin bundles

Force-producing ADP state of myosin bound to actin

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening.

How Actin Initiates the Motor Activity of Myosin

Myosin VI deafness mutation prevents the initiation of processive runs on actin

How actin initiates the motor activity of Myosin.

Myosin VI deafness mutation prevents the initiation of processive runs on actin

Structural basis of myosin V Rab GTPase-dependent cargo recognition

Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI

How myosin motors power cellular functions - an exciting journey from structure to function

Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI

Essential "ankle" in the myosin lever arm

Role of Insert-1 of Myosin VI in Modulating Nucleotide Affinity

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4.

Structural Basis for Recruitment of Rab6-Interacting Protein 1 to Golgi via a RUN Domain.

Electrospray ionization mass spectrometry studies of noncovalent myosin VI complexes reveal a new specific calmodulin binding site

The unique insert in myosin VI is a structural calcium-calmodulin binding site

Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients

Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)

Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients

Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex.

Three-dimensional structure and antigen binding specificity of antibodies

Myosin Structures.

Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design

Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis