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Evaluation of the inhibitory activity of (aza)isoindolinone-type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis

Aurélien Chollet , Jean-Luc Stigliani , Maria Rosalia Pasca , Giorgia Mori , Christian Lherbet , et al.
Chemical Biology and Drug Design, 2016, 88 (5), pp.740-755. ⟨10.1111/cbdd.12804⟩
Article dans une revue istex hal-01929908v1

1H and 13C NMR characterization of isoniazid-NAD pyridinium-type adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis

Sylvain Broussy , Vania Bernardes-Génisson , Yannick Coppel , A. Quémard , Jean Bernadou , et al.
Organic & Biomolecular Chemistry, 2005, 3, pp.670-673
Article dans une revue hal-00078731v1

The first chemical synthesis of the core structure of the benzoylhydrazine-NAD adduct, a competitive inhibitor of the Mycobacterium tuberculosis enoyl reductase

Sylvain Broussy , Vania Bernardes-Génisson , A. Quémard , Jean Bernadou , B. Meunier
Journal of Organic Chemistry, 2005, 70, pp.10502-10510
Article dans une revue hal-00077300v1
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HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness

Cyril Lefebvre , Richard Boulon , Manuelle Ducoux , Sabine Gavalda , Françoise Laval , et al.
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-24380-5⟩
Article dans une revue hal-02179486v1
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The Polyketide Synthase Pks13 Catalyzes a Novel Mechanism of Lipid Transfer in Mycobacteria

Sabine Gavalda , Fabienne Bardou , Françoise Laval , Cécile Bon , Wladimir Malaga , et al.
Chemistry and Biology, 2014, 21 (12), pp.1660 - 1669. ⟨10.1016/j.chembiol.2014.10.011⟩
Article dans une revue hal-03002982v1

Negative regulation by Ser/Thr phosphorylation of HadAB and HadBC dehydratases from Mycobacterium tuberculosis type II fatty acid synthase system

Nawel Slama , Jade Leiba , Nathalie Eynard , Mamadou Daffé , Laurent Kremer , et al.
Biochemical and Biophysical Research Communications, 2011, 412 (3), pp.401-406. ⟨10.1016/j.bbrc.2011.07.051⟩
Article dans une revue istex hal-02282724v1
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The Dual Function of the Mycobacterium tuberculosis FadD32 Required for Mycolic Acid Biosynthesis

Mathieu Léger , Sabine Gavalda , Valérie Guillet , Benoît van Der Rest , Nawel Slama , et al.
Chemistry and Biology, 2009, 16, pp.510 - 519. ⟨10.1016/j.chembiol.2009.03.012⟩
Article dans une revue hal-03003389v1
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Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases

Alexandre Faille , Sabine Gavalda , Nawel Slama , Christian Lherbet , Laurent Maveyraud , et al.
Journal of Molecular Biology, 2017, 429 (47), pp.1554 - 1569. ⟨10.1016/j.jmb.2017.03.026⟩
Article dans une revue hal-03002100v1

Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family

Emmanuelle Sacco , Virginie Legendre , Françoise Laval , Didier Zerbib , Henri Montrozier , et al.
Biochimica et Biophysica Acta Proteins and Proteomics, 2007, 1774 (2), pp.303 - 311. ⟨10.1016/j.bbapap.2006.11.016⟩
Article dans une revue istex hal-01883516v1

Enzymic Characterization of the Target for Isoniazid in Mycobacterium tuberculosis

Annaïk Quémard , Annaiek Quemard , James Sacchettini , Andréa Dessen , Catherine Vilcheze , et al.
Biochemistry, 2002, 34 (26), pp.8235-8241. ⟨10.1021/bi00026a004⟩
Article dans une revue istex hal-03066406v1
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Biochemical and Structural Study of the Atypical Acyltransferase Domain from the Mycobacterial Polyketide Synthase Pks13

Fabien Bergeret , Sabine Gavalda , Christian Chalut , Wladimir Malaga , Annaïk Quémard , et al.
Journal of Biological Chemistry, 2012, 287, pp.33675 - 33690. ⟨10.1074/jbc.m111.325639⟩
Article dans une revue hal-03003064v1

Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change

M. Cohen-Gonsaud , S. Ducasse , A. Quémard , G. Labesse
Proteins - Structure, Function and Bioinformatics, 2005, 60 (3), pp.392-400
Article dans une revue hal-00077525v1
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Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth

Aurélien Chollet , Georgia Mori , Christophe Menendez , Frédéric Rodriguez , Isabelle Fabing , et al.
European Journal of Medicinal Chemistry, 2015, 101, pp.218-235. ⟨10.1016/j.ejmech.2015.06.035⟩
Article dans une revue hal-01920338v1
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The Pks13/FadD32 Crosstalk for the Biosynthesis of Mycolic Acids in Mycobacterium tuberculosis

Sabine Gavalda , Mathieu Léger , Benoît van Der Rest , Alexandre Stella , Fabienne Bardou , et al.
Journal of Biological Chemistry, 2009, 284 (29), pp.19255-19264. ⟨10.1074/jbc.M109.006940⟩
Article dans une revue hal-03003050v1
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Further Insight into S-Adenosylmethionine-dependent Methyltransferases: STRUCTURAL CHARACTERIZATION OF Hma, AN ENZYME ESSENTIAL FOR THE BIOSYNTHESIS OF OXYGENATED MYCOLIC ACIDS IN MYCOBACTERIUM TUBERCULOSIS

Fanny Boissier , Fabienne Bardou , Valérie Guillet , Sandrine Uttenweiler-Joseph , Mamadou Daffé , et al.
Journal of Biological Chemistry, 2006, 281 (7), pp.4434-4445. ⟨10.1074/jbc.M510250200⟩
Article dans une revue hal-03003456v1

HadBD dehydratase from Mycobacterium tuberculosis fatty acid synthase type II : A singular structure for a unique function

Pascaline Bories , Julie Rima , Samuel Tranier , Julien Marcoux , Yasmina Grimoire , et al.
Protein Science, 2024, 33 (4), ⟨10.1002/pro.4964⟩
Article dans une revue hal-04514640v1

Preliminary Investigations of the Effect of Lipophilic Analogues of the Active Metabolite of Isoniazid Toward Bacterial and Plasmodial Strains

Tamara Delaine , Vania Bernardes-Génisson , Annaïk Quémard , Patricia Constant , Frédéric Coslédan , et al.
Chemical Biology & Drug Design, 2012, 79 (6), pp.1001-1006. ⟨10.1111/j.1747-0285.2012.01374.x⟩
Article dans une revue hal-02909742v1

Mycobacterium bovis BCG genes involved in the biosynthesis of cyclopropyl keto‐ and hydroxy‐mycolic acids

Eugenie Dubnau , Marie‐antoinette Lanéelle , Sonia Soares , Anne Bénichou , Tania Vaz , et al.
Molecular Microbiology, 2003, 23 (2), pp.313-322. ⟨10.1046/j.1365-2958.1997.2301589.x⟩
Article dans une revue hal-03066402v1

Crystal Structure of MabA from Mycobacterium tuberculosis, a Reductase involved in Long-chain Fatty Acid Biosynthesis

Martin Cohen-Gonsaud , Stéphanie Ducasse , Francois Hoh , Didier Zerbib , Gilles Labesse , et al.
Journal of Molecular Biology, 2002, 320 (2), pp.249-261. ⟨10.1016/S0022-2836(02)00463-1⟩
Article dans une revue istex hal-02359522v1

Mycolic Acids: From Chemistry to Biology

Mamadou Daffé , Annaïk Quémard , Hedia Marrakchi
Biogenesis of Fatty Acids, Lipids and Membranes, Springer International Publishing, pp.181-216, 2019, ⟨10.1007/978-3-319-50430-8_18⟩
Chapitre d'ouvrage hal-02388910v1
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Acylation of glycerolipids in mycobacteria

Shiva Kumar Angala , Ana Carreras-Gonzalez , Emilie Huc-Claustre , Itxaso Anso , Devinder Kaur , et al.
Nature Communications, 2023, 14 (1), pp.6694. ⟨10.1038/s41467-023-42478-x⟩
Article dans une revue hal-04264659v1

The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis

Nawel Slama , Stevie Jamet , Wafa Frigui , Alexandre Pawlik , Daria Bottai , et al.
Molecular Microbiology, 2016, 99 (4), pp.794-807. ⟨10.1111/mmi.13266⟩
Article dans une revue pasteur-02618562v1
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Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis

Cyril Lefebvre , Wafa Frigui , Nawel Slama , Françoise Lauzeral-Vizcaino , Patricia Constant , et al.
Scientific Reports, 2020, 10 (1), pp.2112. ⟨10.1038/s41598-020-58967-8⟩
Article dans une revue pasteur-02474005v1
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S-Adenosyl-N-decyl-aminoethyl, a Potent Bisubstrate Inhibitor ofMycobacterium tuberculosisMycolic Acid Methyltransferases

Julien Vaubourgeix , Fabienne Bardou , Fanny Boissier , Sylviane Julien , Patricia Constant , et al.
Journal of Biological Chemistry, 2009, 284, pp.19321 - 19330. ⟨10.1074/jbc.m809599200⟩
Article dans une revue hal-03003382v1