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Alice Lebreton, chef d'équipe, CRCN INRA, HDR

Carrière de recherche

Depuis 2015 
 Chef d’équipe à l’Institut de Biologie de l’ENS de Paris, CR1 INRA, HDR.
2008-2014  Chargée de recherche INRA à l’Institut Pasteur, Paris, unité P. Cossart, groupe H. Bierne.
2006-2008  Post-doctorat au Centre de Génétique Moléculaire du CNRS à Gif-sur-Yvette, équipe B. Séraphin.
2002-2006  Doctorat à l’Institut Pasteur, équipe A. Jacquier, supervision M. Fromont-Racine.
2000  Échange Erasmus à l’Institut de Microbiologie de l’ETH de Zürich, laboratoire de Th. Leisinger.
1999  Stage d’été à l’hôpital de la Pitié-Salpêtrière.
   

Enseignement

Actuellement  Professeure chargée de cours à l’École normale supérieure.
Responsable de l’UE Biologie moléculaire de la cellule (L3 non biologistes), co-responsable du cours Systèmes microbiens du M2 IMaLiS.
Enseignement à l’ENS de Cachan, M1 Biologie et santé, UE Biologie cellulaire des interactions hôte-bactéries invasives.
2002-2005  Monitorat à l’Université Paris 7 : travaux dirigés et pratiques d’immunologie (L2, L3).
   

Formation

2002-2006  Doctorat de Microbiologie-Virologie de l’Université Paris 7, école doctorale B2M.
1998-2002  Élève à l’École normale supérieure de Cachan, agrégation de Biochimie – Génie Biologique.
Licence et Maîtrise de Biochimie Moléculaire et Cellulaire puis cours Pasteur et DEA de Microbiologie-Virologie de l’Université Paris 7.

Article dans une revue27 documents

  • Vinko Besic, Fatemeh Habibolahi, Benoit Noel, Sebastian Rupp, Auguste Genovesio, et al.. Coordination of transcriptional and translational regulations in human cells infected by Listeria monocytogenes. RNA Biology, Taylor & Francis, 2020, 17 (10), pp.1492-1507. ⟨10.1080/15476286.2020.1777380⟩. ⟨hal-02308583v2⟩
  • Mary Aubry, Wei-An Wang, Yohan Guyodo, Eugénia Delacou, Jean-Michel Guignier, et al.. Engineering E. coli for magnetic control and the spatial localization of functions. ACS Synthetic Biology, American Chemical Society, 2020. ⟨hal-03038795⟩
  • Caroline Peron Cane, José Carlos Fernandez, Julien Leblanc, Laure Wingertsmann, Arnaud Gautier, et al.. Fluorescent secreted bacterial effectors reveal active intravacuolar proliferation of Listeria monocytogenes in epithelial cells. PLoS Pathogens, Public Library of Science, 2020, 16 (10), pp.e1009001. ⟨10.1371/journal.ppat.1009001⟩. ⟨hal-02424854v2⟩
  • Yankel Chekli, Caroline Peron-Cane, Dario Dell’arciprete, Jean-François Allemand, Chenge Li, et al.. Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST. Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.15791. ⟨10.1038/s41598-020-72498-2⟩. ⟨hal-03093348⟩
  • Mathieu Bahin, Benoit Noel, Valentine Murigneux, Charles Bernard, Leila Bastianelli, et al.. ALFA: annotation landscape for aligned reads. BMC Genomics, BioMed Central, 2019, 20 (250), pp.1-11. ⟨10.1186/s12864-019-5624-2⟩. ⟨hal-02084432⟩
  • Alessandro Pagliuso, To Nam Tham, Eric Allemand, Stevens Robertin, Bruno Dupuy, et al.. An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling. Cell Host and Microbe, Elsevier, 2019, ⟨10.1016/j.chom.2019.10.004⟩. ⟨pasteur-02390001⟩
  • Alice Lebreton, Pascale Cossart. RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression. RNA Biology, Taylor & Francis, 2017, 14 (5), pp.460-470. ⟨10.1080/15476286.2016.1189069⟩. ⟨hal-01350979⟩
  • Mélodie Duval, Pascale Cossart, Alice Lebreton. Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk. Seminars in Cell and Developmental Biology, Elsevier, 2017, 65, pp.11-19. ⟨10.1016/j.semcdb.2016.06.016⟩. ⟨hal-01350977⟩
  • Alice Lebreton, Fabrizia Stavru, Sylvain Brisse, Pascale Cossart. 1926–2016: 90 Years of listeriology. Microbes and Infection, Elsevier, 2016, 18 (12), pp.711 - 723. ⟨10.1016/j.micinf.2016.10.009⟩. ⟨hal-01400517⟩
  • Goran Lakisic, Alice Lebreton, Renaud Pourpre, Olivia Wendling, Emanuele Libertini, et al.. Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism. PLoS Genetics, Public Library of Science, 2016, 12 (3), pp.e1005898. ⟨10.1371/journal.pgen.1005898⟩. ⟨hal-01350966⟩
  • Alice Lebreton, Fabrizia Stavru, Pascale Cossart. Organelle targeting during bacterial infection: insights from Listeria. Trends in Cell Biology, Elsevier, 2015, 25 (6), pp.330-8. ⟨10.1016/j.tcb.2015.01.003⟩. ⟨pasteur-01162370⟩
  • Alice Lebreton, Viviana Job, Marie Ragon, Alban Le Monnier, Andréa Dessen, et al.. Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA.. mBio, American Society for Microbiology, 2014, 5 (1), pp.e00775-13. ⟨10.1128/mBio.00775-13⟩. ⟨hal-01109386⟩
  • Emanuele Libertini, Alice Lebreton, Goran Lakisic, Marie-Agnès Dillies, Stephan Beck, et al.. Overexpression of the Heterochromatinization Factor BAHD1 in HEK293 Cells Differentially Reshapes the DNA Methylome on Autosomes and X Chromosome. Frontiers in Genetics, Frontiers, 2014, 6, pp.339. ⟨10.3389/fgene.2015.00339⟩. ⟨hal-01350961⟩
  • Pascale Cossart, Alice Lebreton. A trip in the "New Microbiology" with the bacterial pathogen Listeria monocytogenes. FEBS Letters, Wiley, 2014, 588 (15), pp.2437-45. ⟨10.1016/j.febslet.2014.05.051⟩. ⟨pasteur-01161887⟩
  • Alice Lebreton, Pascale Cossart, Hélène Bierne. Bacteria tune interferon responses by playing with chromatin. Virulence, Taylor & Francis, 2012, 3 (1), pp.87-91. ⟨10.4161/viru.3.1.18531⟩. ⟨hal-01350803⟩
  • Rajani Kanth Gudipati, Zhenyu Xu, Alice Lebreton, Bertrand Séraphin, Lars M Steinmetz, et al.. Extensive degradation of RNA precursors by the exosome in wild-type cells.. Molecular Cell, Elsevier, 2012, 48 (3), pp.409-21. ⟨10.1016/j.molcel.2012.08.018⟩. ⟨hal-01350901⟩
  • Hélène Bierne, Laetitia Travier, Tanel Mahlakõiv, Ludovic Tailleux, Agathe Subtil, et al.. Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta.. PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e39080. ⟨10.1371/journal.pone.0039080⟩. ⟨pasteur-00750162⟩
  • Cristel Archambaud, Odile Sismeiro, Joern Toedling, Guillaume Soubigou, Christophe Bécavin, et al.. The intestinal microbiota interferes with the microRNA response upon oral Listeria infection.. mBio, American Society for Microbiology, 2012, 4 (6), pp.e00707-13. ⟨10.1128/mBio.00707-13⟩. ⟨hal-01350904⟩
  • Alice Lebreton, Goran Lakisic, Viviana Job, Lauriane Fritsch, To Nam Tham, et al.. A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science, American Association for the Advancement of Science, 2011, 331 (6022), pp.1319-21. ⟨10.1126/science.1200120⟩. ⟨cea-00819299⟩
  • Alice Lebreton, Jean-Claude Rousselle, Pascal Lenormand, Abdelkader Namane, Alain Jacquier, et al.. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Nucleic Acids Research, Oxford University Press, 2008, 36 (15), pp.4988-4999. ⟨10.1093/nar/gkn469⟩. ⟨hal-01350774⟩
  • Alice Lebreton, Bertrand Séraphin. Exosome-mediated quality control: substrate recruitment and molecular activity. BBA - Biochimica et Biophysica Acta, Elsevier, 2008, 1779 (9), pp.558-65. ⟨10.1016/j.bbagrm.2008.02.003⟩. ⟨hal-01350691⟩
  • Alice Lebreton, Rafal Tomecki, Andrzej Dziembowski, Bertrand Séraphin. Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature, Nature Publishing Group, 2008, 456 (7224), pp.993-6. ⟨10.1038/nature07480⟩. ⟨hal-01350769⟩
  • Brigitte Pertschy, Cosmin Saveanu, Gertrude Zisser, Alice Lebreton, Martin Tengg, et al.. Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1. Molecular and Cellular Biology, American Society for Microbiology, 2007, 27 (19), pp.6581-92. ⟨10.1128/MCB.00668-07⟩. ⟨hal-01350677⟩
  • Alice Lebreton, Cosmin Saveanu, Laurence Decourty, Alain Jacquier, Micheline Fromont-Racine. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (37), pp.27099-108. ⟨10.1074/jbc.M602199200⟩. ⟨hal-01350676⟩
  • Alice Lebreton, Cosmin Saveanu, Laurence Decourty, Jean-Christophe Rain, Alain Jacquier, et al.. A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. Journal of Cell Biology, Rockefeller University Press, 2006, 173 (3), pp.349-60. ⟨10.1083/jcb.200510080⟩. ⟨hal-01350674⟩
  • Cosmin Saveanu, Abdelkader Namane, Pierre-Emmanuel Gleizes, Alice Lebreton, Jean-Claude Rousselle, et al.. Sequential protein association with nascent 60S ribosomal particles. Molecular and Cellular Biology, American Society for Microbiology, 2003, 23 (13), pp.4449-60. ⟨10.1128/MCB.23.13.4449-4460.2003⟩. ⟨hal-01350680⟩
  • Susana de Azevedo Wäsch, Jan van der Ploeg, Tere Maire, Alice Lebreton, Andreas Kiener, et al.. Transformation of isopropylamine to L-alaninol by Pseudomonas sp. strain KIE171 involves N-glutamylated intermediates. Applied and Environmental Microbiology, American Society for Microbiology, 2002, 68 (5), pp.2368-75. ⟨10.1128/AEM.68.5.2368-2375.2002⟩. ⟨hal-01350667⟩

Thèse1 document

  • Alice Lebreton. Dynamique des facteurs pré-ribosomiques au cours de la biogenèse de la grande sous-unité ribosomique chez S. cerevisiae. Biochimie [q-bio.BM]. Université Paris-Diderot - Paris VII, 2006. Français. ⟨tel-00100381⟩

HDR1 document

  • Alice Lebreton. Régulations post-transcriptionnelles de l'expression génique de la cellule hôte en réponse à l'infection bactérienne. Sciences du Vivant [q-bio]. Université Paris Diderot (Paris 7), 2015. ⟨tel-02471940v2⟩