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Alice Lebreton, Group leader, INRA researcher, HDR

Research career

Since 2015  Group leader, Institute of Biology of École normale supérieure (IBENS), Paris, HDR.
2008-2014  INRA Research scientist (CR1), Pasteur Institute (lab P. Cossart, group H. Bierne), Paris.
2006-2008  Post-doctoral fellow, Centre de Génétique Moléculaire (lab B. Séraphin), CNRS, Gif-sur-Yvette.
2002-2006  PhD thesis student, Pasteur Institute (lab A. Jacquier, supervision M. Fromont-Racine), Paris.
2000  Intern, Microbiology Institute (lab Th. Leisinger), ETH Zürich.
1999  Summer intern, La Pitié-Salpêtrière hospital, Paris.


Currently  Lecturer for the biology department of École normale supérieure.
Organisation of the Molecular Cell Biology course for non-biologist students at ENS (Bachelor’s degree), co-organisation of the Microbial Systems course, (IMaLiS Master’s degree).
Lecturer at ENS Cachan for the Cell Biology of Host-Invasive Bacteria Interactions course (Master’s degree).
2002-2005  Teaching assistant in Immunology (Bachelor’s degree), Paris 7 University.


2002-2006  PhD in Microbiology-Virology, Paris 7 University.
1998-2002  Studies in Biochemistry and Cell Biology at École normale supérieure de Cachan and Paris 7 University.
Undergraduate studies in Biochemistry and Cell Biology, then Master’s degree in Microbiology-Virology (Pasteur Institute).
Agrégation (French degree for high-school teaching) in Biochemistry – Biological Engineering.

Journal articles28 documents

  • Thomas J.P. Petit, Alice Lebreton. Adaptations of intracellular bacteria to vacuolar or cytosolic niches. Trends in Microbiology, Elsevier, 2022, pp.1-13. ⟨10.1016/j.tim.2022.01.015⟩. ⟨hal-03602380⟩
  • Vinko Besic, Fatemeh Habibolahi, Benoit Noel, Sebastian Rupp, Auguste Genovesio, et al.. Coordination of transcriptional and translational regulations in human cells infected by Listeria monocytogenes. RNA Biology, Taylor & Francis, 2020, 17 (10), pp.1492-1507. ⟨10.1080/15476286.2020.1777380⟩. ⟨hal-02308583v2⟩
  • Mary Aubry, Wei-An Wang, Yohan Guyodo, Eugénia Delacou, Jean-Michel Guignier, et al.. Engineering E. coli for magnetic control and the spatial localization of functions. ACS Synthetic Biology, American Chemical Society, 2020. ⟨hal-03038795⟩
  • Yankel Chekli, Caroline Peron-Cane, Dario Dell’arciprete, Jean-François Allemand, Chenge Li, et al.. Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST. Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.15791. ⟨10.1038/s41598-020-72498-2⟩. ⟨hal-03093348⟩
  • Caroline Peron Cane, José Carlos Fernandez, Julien Leblanc, Laure Wingertsmann, Arnaud Gautier, et al.. Fluorescent secreted bacterial effectors reveal active intravacuolar proliferation of Listeria monocytogenes in epithelial cells. PLoS Pathogens, Public Library of Science, 2020, 16 (10), pp.e1009001. ⟨10.1371/journal.ppat.1009001⟩. ⟨hal-02424854v2⟩
  • Mathieu Bahin, Benoit Noel, Valentine Murigneux, Charles Bernard, Leila Bastianelli, et al.. ALFA: annotation landscape for aligned reads. BMC Genomics, BioMed Central, 2019, 20 (250), pp.1-11. ⟨10.1186/s12864-019-5624-2⟩. ⟨hal-02084432⟩
  • Alessandro Pagliuso, To Nam Tham, Eric Allemand, Stevens Robertin, Bruno Dupuy, et al.. An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling. Cell Host and Microbe, Elsevier, 2019, ⟨10.1016/j.chom.2019.10.004⟩. ⟨pasteur-02390001⟩
  • Mélodie Duval, Pascale Cossart, Alice Lebreton. Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk. Seminars in Cell and Developmental Biology, Elsevier, 2017, 65, pp.11-19. ⟨10.1016/j.semcdb.2016.06.016⟩. ⟨hal-01350977⟩
  • Alice Lebreton, Pascale Cossart. RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression. RNA Biology, Taylor & Francis, 2017, 14 (5), pp.460-470. ⟨10.1080/15476286.2016.1189069⟩. ⟨hal-01350979⟩
  • Goran Lakisic, Alice Lebreton, Renaud Pourpre, Olivia Wendling, Emanuele Libertini, et al.. Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism. PLoS Genetics, Public Library of Science, 2016, 12 (3), pp.e1005898. ⟨10.1371/journal.pgen.1005898⟩. ⟨hal-01350966⟩
  • Alice Lebreton, Fabrizia Stavru, Sylvain Brisse, Pascale Cossart. 1926–2016: 90 Years of listeriology. Microbes and Infection, Elsevier, 2016, 18 (12), pp.711 - 723. ⟨10.1016/j.micinf.2016.10.009⟩. ⟨hal-01400517⟩
  • Alice Lebreton, Fabrizia Stavru, Pascale Cossart. Organelle targeting during bacterial infection: insights from Listeria. Trends in Cell Biology, Elsevier, 2015, 25 (6), pp.330-8. ⟨10.1016/j.tcb.2015.01.003⟩. ⟨pasteur-01162370⟩
  • Emanuele Libertini, Alice Lebreton, Goran Lakisic, Marie-Agnès Dillies, Stephan Beck, et al.. Overexpression of the Heterochromatinization Factor BAHD1 in HEK293 Cells Differentially Reshapes the DNA Methylome on Autosomes and X Chromosome. Frontiers in Genetics, Frontiers, 2014, 6, pp.339. ⟨10.3389/fgene.2015.00339⟩. ⟨hal-01350961⟩
  • Pascale Cossart, Alice Lebreton. A trip in the "New Microbiology" with the bacterial pathogen Listeria monocytogenes. FEBS Letters, Wiley, 2014, 588 (15), pp.2437-45. ⟨10.1016/j.febslet.2014.05.051⟩. ⟨pasteur-01161887⟩
  • Alice Lebreton, Viviana Job, Marie Ragon, Alban Le Monnier, Andréa Dessen, et al.. Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA.. mBio, American Society for Microbiology, 2014, 5 (1), pp.e00775-13. ⟨10.1128/mBio.00775-13⟩. ⟨hal-01109386⟩
  • Alice Lebreton, Pascale Cossart, Hélène Bierne. Bacteria tune interferon responses by playing with chromatin. Virulence, Taylor & Francis, 2012, 3 (1), pp.87-91. ⟨10.4161/viru.3.1.18531⟩. ⟨hal-01350803⟩
  • Cristel Archambaud, Odile Sismeiro, Joern Toedling, Guillaume Soubigou, Christophe Bécavin, et al.. The intestinal microbiota interferes with the microRNA response upon oral Listeria infection.. mBio, American Society for Microbiology, 2012, 4 (6), pp.e00707-13. ⟨10.1128/mBio.00707-13⟩. ⟨hal-01350904⟩
  • Hélène Bierne, Laetitia Travier, Tanel Mahlakõiv, Ludovic Tailleux, Agathe Subtil, et al.. Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta.. PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e39080. ⟨10.1371/journal.pone.0039080⟩. ⟨pasteur-00750162⟩
  • Rajani Kanth Gudipati, Zhenyu Xu, Alice Lebreton, Bertrand Séraphin, Lars M Steinmetz, et al.. Extensive degradation of RNA precursors by the exosome in wild-type cells.. Molecular Cell, Cell Press, 2012, 48 (3), pp.409-21. ⟨10.1016/j.molcel.2012.08.018⟩. ⟨hal-01350901⟩
  • Alice Lebreton, Goran Lakisic, Viviana Job, Lauriane Fritsch, To Nam Tham, et al.. A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science, American Association for the Advancement of Science (AAAS), 2011, 331 (6022), pp.1319-21. ⟨10.1126/science.1200120⟩. ⟨cea-00819299⟩
  • Alice Lebreton, Bertrand Séraphin. Exosome-mediated quality control: substrate recruitment and molecular activity. BBA - Biochimica et Biophysica Acta, Elsevier, 2008, 1779 (9), pp.558-65. ⟨10.1016/j.bbagrm.2008.02.003⟩. ⟨hal-01350691⟩
  • Alice Lebreton, Jean-Claude Rousselle, Pascal Lenormand, Abdelkader Namane, Alain Jacquier, et al.. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Nucleic Acids Research, Oxford University Press, 2008, 36 (15), pp.4988-4999. ⟨10.1093/nar/gkn469⟩. ⟨hal-01350774⟩
  • Alice Lebreton, Rafal Tomecki, Andrzej Dziembowski, Bertrand Séraphin. Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature, Nature Publishing Group, 2008, 456 (7224), pp.993-6. ⟨10.1038/nature07480⟩. ⟨hal-01350769⟩
  • Brigitte Pertschy, Cosmin Saveanu, Gertrude Zisser, Alice Lebreton, Martin Tengg, et al.. Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1. Molecular and Cellular Biology, American Society for Microbiology, 2007, 27 (19), pp.6581-92. ⟨10.1128/MCB.00668-07⟩. ⟨hal-01350677⟩
  • Alice Lebreton, Cosmin Saveanu, Laurence Decourty, Alain Jacquier, Micheline Fromont-Racine. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (37), pp.27099-108. ⟨10.1074/jbc.M602199200⟩. ⟨hal-01350676⟩
  • Alice Lebreton, Cosmin Saveanu, Laurence Decourty, Jean-Christophe Rain, Alain Jacquier, et al.. A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. Journal of Cell Biology, Rockefeller University Press, 2006, 173 (3), pp.349-60. ⟨10.1083/jcb.200510080⟩. ⟨hal-01350674⟩
  • Cosmin Saveanu, Abdelkader Namane, Pierre-Emmanuel Gleizes, Alice Lebreton, Jean-Claude Rousselle, et al.. Sequential protein association with nascent 60S ribosomal particles. Molecular and Cellular Biology, American Society for Microbiology, 2003, 23 (13), pp.4449-60. ⟨10.1128/MCB.23.13.4449-4460.2003⟩. ⟨hal-01350680⟩
  • Susana I de Azevedo Wäsch, Jan R van Der Ploeg, Tere Maire, Alice Lebreton, Andreas Kiener, et al.. Transformation of isopropylamine to L-alaninol by Pseudomonas sp. strain KIE171 involves N-glutamylated intermediates. Applied and Environmental Microbiology, American Society for Microbiology, 2002, 68 (5), pp.2368-75. ⟨10.1128/AEM.68.5.2368-2375.2002⟩. ⟨hal-01350667⟩

Theses1 document

  • Alice Lebreton. Dynamique des facteurs pré-ribosomiques au cours de la biogenèse de la grande sous-unité ribosomique chez S. cerevisiae. Biochimie [q-bio.BM]. Université Paris-Diderot - Paris VII, 2006. Français. ⟨tel-00100381⟩

Habilitation à diriger des recherches1 document

  • Alice Lebreton. Régulations post-transcriptionnelles de l'expression génique de la cellule hôte en réponse à l'infection bactérienne. Sciences du Vivant [q-bio]. Université Paris Diderot (Paris 7), 2015. ⟨tel-02471940v2⟩