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48

Alice JOUNEAU


Research Scientist, project leader in developmental biology and stem cell research

My main project is to understand how pluripotency is established in the mammalian embryo and how it is controlled at the molecular and epigenetic levels. I have an internationally recognized expertise and more than 20 papers in mammalian embryo development and pluripotency in mammalian species. I have developed and used several approaches such as high throughput analyses (transcriptome and epigenome), cell biology and imaging, and in vitro derivation of cell lines from epiblast and trophoblast

 

Born in Paris (France) on February 13th, 1968

Married

Address : UMR BREED Biologie de la Reproduction, Epigénétique, Environnement et Développement, INRAE

                         Domaine de Vilvert

                         78352 Jouy en Josas Cedex, France

                         E.mail : alice.jouneau@inrae.fr

 

Education & Professional experience

·      1999 - present : Research scientist INRA, Biologie du Développement et Reproduction.

·      2005-2007: Associate Professor of Chinese Academy of Sciences, The Sino-French (INRA/CAS) Laboratory LABIOCEM, Institute of Zoology, Beijing China

·      1997-1999: Post-doctoral fellow, the Laboratory of Developmental Genetics of the Melanocytes, directed by Dr. Lionel Larue, UMR 146, Institut Curie-Orsay, France

·      1992-1996: PhD student, laboratory of Cellular morphogenesis and Tumor Progression, directed by Jean-Paul Thiery, UMR 144, Institut Curie-, France


Journal articles42 documents

  • Guillaume Bourdon, Véronique Cadoret, Gilles Charpigny, Anne Couturier-Tarrade, Rozenn Dalbies-Tran, et al.. Progress and challenges in developing organoids in farm animal species for the study of reproduction and their applications to reproductive biotechnologies. Veterinary Research, BioMed Central, 2021, 52 (1), pp.42. ⟨10.1186/s13567-020-00891-w⟩. ⟨hal-03168949⟩
  • Emma Bell, Edward W. Curry, Wout Megchelenbrink, Luc Jouneau, Vincent Brochard, et al.. Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency. Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-14916-7⟩. ⟨hal-02508171⟩
  • Guenhaël Sanz, Nathalie Daniel, Catherine Archilla, Luc Jouneau, Yan Jaszczyszyn, et al.. Differentiation of derived rabbit trophoblast stem cells under fluid shear stress to mimic the trophoblastic barrier. Biochimica et Biophysica Acta (BBA) - General Subjects, Elsevier, 2019, 1863, Issue 10, pp.1608-1618. ⟨10.1016/j.bbagen.2019.07.003⟩. ⟨hal-02183790⟩
  • René a M Dirks, Guido van Mierlo, Hindrik H D Kerstens, Andreia S Bernardo, Julianna Kobolak, et al.. Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states. Epigenetics and Chromatin, BioMed Central, 2019, 12 (1), pp.1-21. ⟨10.1186/s13072-019-0259-8⟩. ⟨hal-02625883⟩
  • Andreia S Bernardo, Alice Jouneau, Hendrik Marks, Philip Kensche, Julianna Kobolak, et al.. Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state.. Biology Open, Royal Society, 2018, ⟨10.1242/bio.033282⟩. ⟨hal-02623684⟩
  • Eugénie Canon, Luc Jouneau, Thierry Blachère, Nathalie Peynot, Nathalie Daniel, et al.. Progressive methylation of POU5F1 regulatory regions during blastocyst development.. Reproduction -Cambridge- Supplement-, Society for Reproduction and Fertility, 2018, 156 (2), pp.145-161. ⟨10.1530/REP-17-0689⟩. ⟨hal-02623175⟩
  • Matteo Tosolini, Vincent Brochard, Pierre Adenot, Martine Chebrout, Giacomo Grillo, et al.. Contrasting epigenetic states of heterochromatin in the different types of mouse pluripotent stem cells. Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.14. ⟨10.1038/s41598-018-23822-4⟩. ⟨hal-02309000⟩
  • Fabienne Nuttinck, Alice Jouneau, Gilles Charpigny, Isabelle Hue, Christophe Richard, et al.. Prosurvival effect of cumulus prostaglandin G/H synthase 2/prostaglandin2 signaling on bovine blastocyst: impact on in vivo posthatching development. Biology of Reproduction, Society for the Study of Reproduction, 2017, 96 (3), pp.531-541. ⟨10.1095/biolreprod.116.145367⟩. ⟨hal-01605027⟩
  • Hendrik Marks, Hindrik H. D. Kerstens, Tahsin Stefan Barakat, Erik Splinter, René A. M. Dirks, et al.. Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq. Genome Biology, BioMed Central, 2016, 17, ⟨10.1186/s13059-016-0885-4⟩. ⟨hal-02630193⟩
  • Caroline Sauvegarde, Delphine Paul, Laure Bridoux, Alice Jouneau, Severine Degrelle, et al.. Dynamic Pattern of HOXB9 Protein Localization during Oocyte Maturation and Early Embryonic Development in Mammals. PLoS ONE, Public Library of Science, 2016, 11 (10), pp.e0165898. ⟨10.1371/journal.pone.0165898⟩. ⟨inserm-02440442⟩
  • Hendrik Marks, Hindrik H. D. Kerstens, Tahsin Stefan Barakat, Erik Splinter, René A. M. Dirks, et al.. Dynamics of gene silencing during X inactivation using allele-specific RNA-seq. Genome Biology, BioMed Central, 2015, 16, ⟨10.1186/s13059-015-0698-x⟩. ⟨hal-02632585⟩
  • Anne-Clémence Veillard, Hendrik Marks, Andreia Sofia Bernardo, Luc Jouneau, Denis Laloë, et al.. Stable methylation at promoters distinguishes epiblast stem cells from embryonic stem cells and the in vivo epiblasts. Stem Cells and Development, Mary Ann Liebert, 2014, 23 (17), pp.2014-2029. ⟨10.1089/scd.2013.0639⟩. ⟨hal-01193858⟩
  • Costis Papanayotou, Ataaillah Benhaddou, Anne Camus, Aitana Perea-Gomez, Alice Jouneau, et al.. A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation.. PLoS Biology, Public Library of Science, 2014, 12 (6), pp.e1001890. ⟨10.1371/journal.pbio.1001890⟩. ⟨hal-01060190⟩
  • Barbara Panneau, Luc Jouneau, Pierre Osteil, Yann Tapponnier, Marielle Afanassieff, et al.. Contrasting transcriptome landscapes of rabbit pluripotent stem cells [i]in vitro[/i] and [i]in vivo[/i]. Animal Reproduction Science, Elsevier Masson, 2014, 149 (1-2), pp.67-79. ⟨10.1016/j.anireprosci.2014.05.014⟩. ⟨hal-01193859⟩
  • Thomas Fröhlich, Miwako Kösters, Alexander Graf, Eckhard Wolf, Julianna Kobolak, et al.. iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells. Journal of Proteomics, Elsevier, 2013, 90, pp.38-51. ⟨10.1016/j.jprot.2013.03.015⟩. ⟨hal-01190583⟩
  • Laurence Gall, Vincent Brochard, Sylvie Ruffini, Ludivine Laffont, Renaud Fleurot, et al.. Intermediate filaments promote nuclear mechanical constraints during somatic cell nuclear transfer in the mouse. CELLULAR REPROGRAMMING, 2012, 14 (6), pp.497-504. ⟨10.1089/cell.2012.0027⟩. ⟨hal-01000765⟩
  • Daulat Raheem Khan, Delphine Dube, Laurence Gall, Nathalie Peynot, Sylvie Ruffini, et al.. Expression of Pluripotency Master Regulators during Two Key Developmental Transitions: EGA and Early Lineage Specification in the Bovine Embryo. PLoS ONE, Public Library of Science, 2012, 7 (3), pp.e34110. ⟨10.1371/journal.pone.0034110⟩. ⟨inserm-02440304⟩
  • Daulat-Raheem Khan, Delphine Dubé, Laurence Gall, Nathalie Peynot, Sylvie Ruffini, et al.. Expression of pluripotency master regulators during two key developmental transitions: EGA and early lineage specification in the bovine embryo. PLoS ONE, Public Library of Science, 2012, 7 (3), pp.1-12. ⟨10.1371/journal.pone.0034110⟩. ⟨hal-01000766⟩
  • Julien Maruotti, Marta Muñoz, Severine Degrelle, Enrique Gómez, Claire Louet, et al.. Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors: Nodal signaling and pluripotency in bovine epiblast. Molecular Reproduction and Development, Wiley, 2012, 79 (7), pp.461-77. ⟨10.1002/mrd.22051⟩. ⟨hal-01000771⟩
  • Alice Jouneau, Constance Ciaudo, Odile Sismeiro, Vincent Brochard, Luc Jouneau, et al.. Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles. RNA, Cold Spring Harbor Laboratory Press, 2012, 18 (2), pp.253-264. ⟨10.1261/rna.028878.111⟩. ⟨hal-01001312⟩
  • Tang Hai, Jie Hao, Liu Wang, Alice Jouneau, Qi Zhou. Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. CELLULAR REPROGRAMMING, 2011, 6 (9), pp.1149-1161. ⟨10.1089/cell.2010.0042⟩. ⟨hal-01001201⟩
  • Olivier Ganier, Stéphane Bocquet, Isabelle Peiffer, Vincent Brochard, Philippe Arnaud, et al.. Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2011, 108 (42), pp.17331-17336. ⟨10.1073/pnas.1100733108⟩. ⟨hal-01000287⟩
  • Yingying Wang, Tang Hai, Zichuan Liu, Shuya Zhou, Zhuo Lv, et al.. HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death. Biochemical and Biophysical Research Communications, Elsevier, 2010, 397 (3), pp.407-412. ⟨10.1016/j.bbrc.2010.05.105⟩. ⟨hal-02664699⟩
  • Alice Jouneau. Reprogrammation nucléaire et pluripotence : l’étrange cas des cellules souches d’épiblaste. médecine/sciences, EDP Sciences, 2010, 26 (10), pp.792-794. ⟨10.1051/medsci/20102610792⟩. ⟨hal-02654341⟩
  • Julien Maruotti, Alice Jouneau, Jean Paul Renard. Faithful reprogramming to pluripotency in mammals - what does nuclear transfer teach us?. International Journal of Developmental Biology, University of the Basque Country Press, 2010, 54 (11-12), pp.1609-1621. ⟨10.1387/ijdb.103195jm⟩. ⟨hal-02667213⟩
  • Julien Maruotti, Xiang Peng Dai, Vincent Brochard, Luc Jouneau, Jun Liu, et al.. Nuclear transfer-derived epiblast stem cells are transcriptionally and epigenetically distinguishable from their fertilized-derived counterparts. STEM CELLS, AlphaMed Press, 2010, 28 (4), pp.743-752. ⟨10.1002/stem.400⟩. ⟨hal-02664747⟩
  • Xiangpeng Dai, Jie Hao, Xiao-Jun Hou, Tang Hai, Yong Fan, et al.. Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (40), pp.31002-31010. ⟨10.1074/jbc.M110.136085⟩. ⟨hal-02664744⟩
  • Maite Rielland, Vincent Brochard, Marie-Christine Lacroix, Jean Paul Renard, Alice Jouneau. Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer. 4387, 2009, 334 (2), pp.325-334. ⟨hal-00490600⟩
  • Maite Rielland, Vincent Brochard, Marie-Christine Lacroix, Jean Paul Renard, Alice Jouneau. Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer. 4387, 2009, 334 (2), pp.325-334. ⟨hal-00489695⟩
  • Maite Rielland, Vincent Brochard, Marie-Christine Lacroix, Jean Paul Renard, Alice Jouneau. Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer. Developmental Biology, Elsevier, 2009, 334 (2), pp.325-334. ⟨10.1016/j.ydbio.2009.07.022⟩. ⟨hal-00490154⟩
  • M Munoz, C Diez, Jn Caamano, Alice Jouneau, Isabelle Hue, et al.. Embryonic stem cells in cattle. Reproduction in Domestic Animals, Wiley, 2008, 43, pp.32-37. ⟨10.1111/j.1439-0531.2008.01229.x⟩. ⟨hal-02658497⟩
  • Maite Rielland, Isabelle Hue, Jean Paul Renard, Alice Jouneau. Trophoblast stem cell derivation, cross-species comparison and use of nuclear transfer: new tools to study trophoblast growth and differentiation. Developmental Biology, Elsevier, 2008, 322 (1), pp.1-10. ⟨10.1016/j.ydbio.2008.07.017⟩. ⟨hal-02665045⟩
  • Yang Yu, Chenui Ding, Eryao Wang, Xinjie Chen, Xuemei Li, et al.. Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis. Reproduction -Cambridge- Supplement-, Society for Reproduction and Fertility, 2007, 133 (5), pp.947-954. ⟨hal-02657905⟩
  • Yang Yu, Chenhui Ding, Eryao Wang, Xinjie Chen, Xuemei Li, et al.. Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis. Reproduction, BioScientifica, 2007, 133 (5), pp.947-954. ⟨10.1530/REP-06-0358⟩. ⟨hal-02610680⟩
  • Jean Paul Renard, Julien Maruotti, Alice Jouneau, Xavier Vignon. Nuclear reprogramming and pluripotency of embryonic cells: Application to the isolation of embryonic stem cells in farm animals. Theriogenology, Elsevier, 2007, 68, pp.S196-S205. ⟨hal-02654315⟩
  • Chunli Zhao, Ruqiang Yao, Jie Hao, Chenhui Ding, Young Fan, et al.. Establishment of customized mouse stem cell lines by sequential nuclear transfer. Cell Research, Nature Publishing Group, 2007, 17 (1), pp.80-87. ⟨hal-02659115⟩
  • Alice Jouneau, Qi Zhou, Anne Camus, Vincent Brochard, Linda Maulny, et al.. Developmental abnormalities of NT mouse embryos appear early after implantation.. Development (Cambridge, England), Company of Biologists, 2006, 133, pp.1597-1607. ⟨10.1242/10.1242/dev.02317⟩. ⟨hal-00096257⟩
  • Alice Jouneau, Qi Zhou, Anne Camus, Vincent Brochard, Linda Maulny, et al.. Developmental abnormalities of NT mouse embryos appear early after implantation. Development (Cambridge, England), Company of Biologists, 2006, 133, pp.1597-1607. ⟨10.1242/dev.02317⟩. ⟨hal-03048850⟩
  • Alice Jouneau, Jean Paul Renard. Reprogramming in nuclear transfer. Current Opinion in Genetics and Development, Elsevier, 2003, 13, pp.486-491. ⟨hal-02676611⟩
  • Xuemei Li, Ziyi Li, Alice Jouneau, Qi Zhou, Jean Paul Renard. Nuclear transfer : progress and quandaries. Reproductive Biology and Endocrinology, BioMed Central, 2003, 1 (84), 6 p. ⟨10.1186/1477-7827-1-84⟩. ⟨hal-02677996⟩
  • Alice Jouneau, Jean Paul Renard. Cellules souches embryonnaires et clonage thérapeutique. médecine/sciences, EDP Sciences, 2002, 18, pp.169-180. ⟨hal-02672187⟩
  • Qi Zhou, Alice Jouneau, Vincent Brochard, Pierre Adenot, Jean Paul Renard. Developmental potential of mouse embryos reconstructed from metaphase embryonic stem cell nuclei. Biology of Reproduction, Society for the Study of Reproduction, 2001, 65, pp.412-419. ⟨hal-02674823⟩

Book sections5 documents

Books1 document