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Alice Jouneau

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Identifiants chercheurs

Présentation

### **CRHC INRAE en Biologie du Développement et cellules souches** né à Paris (France) le 13/02/1968 Addresse : UMR BREED Biologie de la Reproduction, Epigénétique, Environnement et Développement, INRAE Domaine de Vilvert 78352 Jouy en Josas Cedex, France E.mail : <alice.jouneau@inrae.fr> ### **profil scientifique :** Mon projet principal est de comprendre comment la pluripotence s'établit dans l'embryon de mammifère et comment elle est contrôlée aux niveaux moléculaire et épigénétique. J'ai une expertise reconnue au niveau international et plus de 20 articles sur le développement des embryons de mammifères et la pluripotence chez la souris, le bovin, le lapin. J'ai développé et utilisé plusieurs approches telles que les analyses à haut débit (transcriptome et épigénome), l'imagerie cellulaire, la dérivation in vitro de lignées cellulaires d'épiblastes et de trophoblastes. ### **Education et Expériences professionnelles :** · 1999 - présent : chercheur INRA, Biologie du Développement et Reproduction, devenu en 2020 Biologie de la Reproduction, Epigénétique, Environnemen et Développement. · 2005-2007: Associate Professor , Chinese Academy of Sciences, The Sino-French (INRA/CAS) Laboratory LABIOCEM, Institute of Zoology, Beijing China · 1997-1999: Post-doctoratau Laboratoire de Génétique du Développement des Mélanocytes, dirigé par Lionel Larue, UMR 146, Institut Curie-Orsay, France · 1992-1996: Doctorat de l'université Paris XI, Laboratoire de Morphogénèse Cellulaire et Progression Tumorale, dirigé par Jean-Paul Thiery, UMR 144, Institut Curie-, France
### Research Scientist, project leader in developmental biology and stem cell research My main project is to understand how pluripotency is established in the mammalian embryo and how it is controlled at the molecular and epigenetic levels. I have an internationally recognized expertise and more than 20 papers in mammalian embryo development and pluripotency in mammalian species. I have developed and used several approaches such as high throughput analyses (transcriptome and epigenome), cell biology and imaging, and in vitro derivation of cell lines from epiblast and trophoblast Born in Paris (France) on February 13th, 1968 Married **Address** : UMR BREED Biologie de la Reproduction, Epigénétique, Environnement et Développement, INRAE Domaine de Vilvert 78352 Jouy en Josas Cedex, France E.mail : <alice.jouneau@inrae.fr> **Education &amp; Professional experience** · 1999 - present : Research scientist INRA, Biologie du Développement et Reproduction. · 2005-2007: Associate Professor of Chinese Academy of Sciences, The Sino-French (INRA/CAS) Laboratory LABIOCEM, Institute of Zoology, Beijing China · 1997-1999: Post-doctoral fellow, the Laboratory of Developmental Genetics of the Melanocytes, directed by Dr. Lionel Larue, UMR 146, Institut Curie-Orsay, France · 1992-1996: PhD student, laboratory of Cellular morphogenesis and Tumor Progression, directed by Jean-Paul Thiery, UMR 144, Institut Curie-, France

Publications

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Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes

Shady Younis , Alice Jouneau , Mårten Larsson , Jean-Francois Oudin , Jihad Omar
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (23), ⟨10.1073/pnas.2216799120⟩
Article dans une revue hal-04127723v1
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Pregnancy bioengineering: getting rid of the uterus?

Olivier Sandra , Emmanuelle Motte-Signoret , Alice Jouneau
Médecine de la Reproduction, 2022, 24 (2), pp.152-157. ⟨10.1684/mte.2022.0891⟩
Article dans une revue hal-04002423v1
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Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development

King Hang Tommy Mau , Donja Karimlou , David Barneda , Vincent Brochard , Christophe Royer
Nature Communications, 2022, 13 (1), pp.3861. ⟨10.1038/s41467-022-31323-2⟩
Article dans une revue hal-03714680v1
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H3K27me3 at pericentromeric heterochromatin is a defining feature of the early mouse blastocyst

Mélanie Pailles , Mélanie Hirlemann , Vincent Brochard , Martine Chebrout , Jean-François Oudin
Scientific Reports, 2022, 12 (1), pp. 13908. ⟨10.1038/s41598-022-17730-x⟩
Article dans une revue hal-03767167v1

Transcription of rRNA in early mouse embryos promotes chromatin reorganization and expression of major satellite repeats

Martine Chebrout , Maïmouna Coura Koné , Habib Jan , Marie Cournut , Martine Letheule
Journal of Cell Science, 2022, 135 (6), ⟨10.1242/jcs.258798⟩
Article dans une revue hal-03642441v1
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Progress and challenges in developing organoids in farm animal species for the study of reproduction and their applications to reproductive biotechnologies

Guillaume Bourdon , Véronique Cadoret , Gilles Charpigny , Anne Couturier-Tarrade , Rozenn Dalbies-Tran
Veterinary Research, 2021, 52 (1), pp.42. ⟨10.1186/s13567-020-00891-w⟩
Article dans une revue hal-03799896v1
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Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency

Emma Bell , Edward W. Curry , Wout Megchelenbrink , Luc Jouneau , Vincent Brochard
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-14916-7⟩
Article dans une revue hal-02508171v1
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Differentiation of derived rabbit trophoblast stem cells under fluid shear stress to mimic the trophoblastic barrier

Guenhaël Sanz , Nathalie Daniel , Catherine Archilla , Luc Jouneau , Yan Jaszczyszyn
Biochimica et Biophysica Acta (BBA) - General Subjects, 2019, 1863 (10), pp.1608-1618. ⟨10.1016/j.bbagen.2019.07.003⟩
Article dans une revue hal-02183790v1
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Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states

René a M Dirks , Guido van Mierlo , Hindrik H D Kerstens , Andreia S Bernardo , Julianna Kobolak
Epigenetics and Chromatin, 2019, 12 (1), pp.1-21. ⟨10.1186/s13072-019-0259-8⟩
Article dans une revue hal-02625883v1
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Contrasting epigenetic states of heterochromatin in the different types of mouse pluripotent stem cells

Matteo Tosolini , Vincent V. Brochard , Pierre Adenot , Martine M. Chebrout , Giacomo Grillo
Scientific Reports, 2018, 8 (1), pp.14. ⟨10.1038/s41598-018-23822-4⟩
Article dans une revue hal-02309000v1

Progressive methylation of POU5F1 regulatory regions during blastocyst development.

Eugénie Canon , Luc Jouneau , Thierry Blachère , Nathalie Peynot , Nathalie Daniel
Reproduction -Cambridge- Supplement-, 2018, 156 (2), pp.145-161. ⟨10.1530/REP-17-0689⟩
Article dans une revue hal-02623175v1
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Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state.

Andreia S Bernardo , Alice Jouneau , Hendrik Marks , Philip Kensche , Julianna Kobolak
Biology Open, 2018, ⟨10.1242/bio.033282⟩
Article dans une revue hal-02623684v1
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Prosurvival effect of cumulus prostaglandin G/H synthase 2/prostaglandin2 signaling on bovine blastocyst: impact on in vivo posthatching development

Fabienne Nuttinck , Alice Jouneau , Gilles Charpigny , Isabelle Hue , Christophe Richard
Biology of Reproduction, 2017, 96 (3), pp.531-541. ⟨10.1095/biolreprod.116.145367⟩
Article dans une revue hal-01605027v1
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Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq

Hendrik Marks , Hindrik H. D. Kerstens , Tahsin Stefan Barakat , Erik Splinter , René A. M. Dirks
Genome Biology, 2016, 17, ⟨10.1186/s13059-016-0885-4⟩
Article dans une revue hal-02630193v1
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Dynamic Pattern of HOXB9 Protein Localization during Oocyte Maturation and Early Embryonic Development in Mammals

Caroline Sauvegarde , Delphine Paul , Laure Bridoux , Alice Jouneau , Severine S. Degrelle
PLoS ONE, 2016, 11 (10), pp.e0165898. ⟨10.1371/journal.pone.0165898⟩
Article dans une revue inserm-02440442v1
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Dynamics of gene silencing during X inactivation using allele-specific RNA-seq

Hendrik Marks , Hindrik H. D. Kerstens , Tahsin Stefan Barakat , Erik Splinter , René A. M. Dirks
Genome Biology, 2015, 16, ⟨10.1186/s13059-015-0698-x⟩
Article dans une revue hal-02632585v1

Stable methylation at promoters distinguishes epiblast stem cells from embryonic stem cells and the in vivo epiblasts

Anne-Clémence Veillard , Hendrik Marks , Andreia Sofia Bernardo , Luc Jouneau , Denis Laloë
Stem Cells and Development, 2014, 23 (17), pp.2014-2029. ⟨10.1089/scd.2013.0639⟩
Article dans une revue hal-01193858v1
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A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation.

Costis Papanayotou , Ataaillah Benhaddou , Anne Camus , Aitana Perea-Gomez , Alice Jouneau
PLoS Biology, 2014, 12 (6), pp.e1001890. ⟨10.1371/journal.pbio.1001890⟩
Article dans une revue hal-01060190v1

Contrasting transcriptome landscapes of rabbit pluripotent stem cells [i]in vitro[/i] and [i]in vivo[/i]

Barbara Panneau , Luc Jouneau , Pierre Osteil , Yann Tapponnier , Marielle Afanassieff
Animal Reproduction Science, 2014, 149 (1-2), pp.67-79. ⟨10.1016/j.anireprosci.2014.05.014⟩
Article dans une revue hal-01193859v1

iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells

Thomas Fröhlich , Miwako Kösters , Alexander Graf , Eckhard Wolf , Julianna Kobolak
Journal of Proteomics, 2013, 90, pp.38-51. ⟨10.1016/j.jprot.2013.03.015⟩
Article dans une revue hal-01190583v1

Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors

Julien J. Maruotti , Marta M. Muñoz , Severine S. Degrelle , Enrique E. Gómez , Claire C. Louet
Molecular Reproduction and Development, 2012, 79 (7), pp.461-77. ⟨10.1002/mrd.22051⟩
Article dans une revue hal-01000771v1

Intermediate filaments promote nuclear mechanical constraints during somatic cell nuclear transfer in the mouse

Laurence Gall Pouget Gall , Vincent V. Brochard , Sylvie S. Ruffini , Ludivine Laffont , Renaud R. Fleurot
CELLULAR REPROGRAMMING, 2012, 14 (6), pp.497-504. ⟨10.1089/cell.2012.0027⟩
Article dans une revue hal-01000765v1
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Expression of pluripotency master regulators during two key developmental transitions: EGA and early lineage specification in the bovine embryo

Daulat-Raheem D.-R. Khan , Delphine Dube Dubé , Laurence Gall Pouget Gall , Nathalie N. Peynot , Sylvie S. Ruffini
PLoS ONE, 2012, 7 (3), pp.1-12. ⟨10.1371/journal.pone.0034110⟩
Article dans une revue hal-01000766v1

Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles

Alice Jouneau , Constance C. Ciaudo , Odile O. Sismeiro , Vincent V. Brochard , Luc Jouneau
RNA, 2012, 18 (2), pp.253-264. ⟨10.1261/rna.028878.111⟩
Article dans une revue hal-01001312v1

Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA

Tang T. Hai , Jie J. Hao , Liu L. Wang , Alice Jouneau , Qi Q. Zhou
CELLULAR REPROGRAMMING, 2011, 6 (9), pp.1149-1161. ⟨10.1089/cell.2010.0042⟩
Article dans une revue hal-01001201v1
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Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors

Olivier O. Ganier , Stéphane S. Bocquet , Isabelle I. Peiffer , Vincent V. Brochard , Philippe P. Arnaud
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (42), pp.17331-17336. ⟨10.1073/pnas.1100733108⟩
Article dans une revue hal-01000287v1

Reprogrammation nucléaire et pluripotence : l’étrange cas des cellules souches d’épiblaste

Alice Jouneau
Médecine/Sciences, 2010, 26 (10), pp.792-794. ⟨10.1051/medsci/20102610792⟩
Article dans une revue hal-02654341v1

Faithful reprogramming to pluripotency in mammals - what does nuclear transfer teach us?

Julien Maruotti , Alice Jouneau , Jean Paul J. P. Renard
International Journal of Developmental Biology, 2010, 54 (11-12), pp.1609-1621. ⟨10.1387/ijdb.103195jm⟩
Article dans une revue hal-02667213v1

Nuclear transfer-derived epiblast stem cells are transcriptionally and epigenetically distinguishable from their fertilized-derived counterparts

Julien Maruotti , Xiang Peng Dai , Vincent V. Brochard , Luc Jouneau , Jun Liu
STEM CELLS, 2010, 28 (4), pp.743-752. ⟨10.1002/stem.400⟩
Article dans une revue hal-02664747v1
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Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor

Xiangpeng Dai , Jie Hao , Xiao-Jun Hou , Tang Hai , Yong Fan
Journal of Biological Chemistry, 2010, 285 (40), pp.31002-31010. ⟨10.1074/jbc.M110.136085⟩
Article dans une revue hal-02664744v1

HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death

Yingying Wang , Tang Hai , Zichuan Liu , Shuya Zhou , Zhuo Lv
Biochemical and Biophysical Research Communications, 2010, 397 (3), pp.407-412. ⟨10.1016/j.bbrc.2010.05.105⟩
Article dans une revue hal-02664699v1
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Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer

Maite M. Rielland , Vincent V. Brochard , Marie-Christine M.-C. Lacroix , Jean Paul J. P. Renard , Alice Jouneau
Developmental Biology, 2009, 334 (2), pp.325-334. ⟨10.1016/j.ydbio.2009.07.022⟩
Article dans une revue hal-00490154v1

Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer

Maite M. Rielland , Vincent V. Brochard , Marie-Christine M.-C. Lacroix , Jean Paul J. P. Renard , Alice Jouneau
4387, 2009, 334 (2), pp.325-334
Article dans une revue hal-00490600v1

Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer

Maite M. Rielland , Vincent V. Brochard , Marie-Christine M.-C. Lacroix , Jean Paul J. P. Renard , Alice Jouneau
4387, 2009, 334 (2), pp.325-334
Article dans une revue hal-00489695v1

Trophoblast stem cell derivation, cross-species comparison and use of nuclear transfer: new tools to study trophoblast growth and differentiation

Maite M. Rielland , Isabelle Hue , Jean Paul J. P. Renard , Alice Jouneau
Developmental Biology, 2008, 322 (1), pp.1-10. ⟨10.1016/j.ydbio.2008.07.017⟩
Article dans une revue hal-02665045v1

Embryonic stem cells in cattle

M Munoz , C Diez , Jn Caamano , Alice Jouneau , Isabelle Hue
Reproduction in Domestic Animals, 2008, 43, pp.32-37. ⟨10.1111/j.1439-0531.2008.01229.x⟩
Article dans une revue hal-02658497v1

Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis

Yang Yu , Chenhui C. Ding , Eryao E. Wang , Xinjie Chen , Xuemei Li
Reproduction, 2007, 133 (5), pp.947-954. ⟨10.1530/REP-06-0358⟩
Article dans une revue hal-02610680v1

Establishment of customized mouse stem cell lines by sequential nuclear transfer

Chunli Zhao , Ruqiang Yao , Jie Hao , Chenhui Ding , Young Fan
Cell Research, 2007, 17 (1), pp.80-87
Article dans une revue hal-02659115v1

Nuclear reprogramming and pluripotency of embryonic cells: Application to the isolation of embryonic stem cells in farm animals

Jean Paul J. P. Renard , Julien Maruotti , Alice Jouneau , Xavier Vignon
Theriogenology, 2007, 68, pp.S196-S205
Article dans une revue hal-02654315v1

Developmental abnormalities of NT mouse embryos appear early after implantation

Alice Jouneau , Qi Zhou , Anne Camus , Vincent V. Brochard , Linda L. Maulny
Development (Cambridge, England), 2006, 133, pp.1597-1607. ⟨10.1242/dev.02317⟩
Article dans une revue hal-03048850v1

Reprogramming in nuclear transfer

Alice Jouneau , Jean Paul J. P. Renard
Current Opinion in Genetics and Development, 2003, 13, pp.486-491
Article dans une revue hal-02676611v1
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Nuclear transfer : progress and quandaries

Xuemei Li , Ziyi Li , Alice Jouneau , Qi Zhou , Jean Paul J. P. Renard
Reproductive Biology and Endocrinology, 2003, 1 (84), 6 p. ⟨10.1186/1477-7827-1-84⟩
Article dans une revue hal-02677996v1

Cellules souches embryonnaires et clonage thérapeutique

Alice Jouneau , Jean Paul J. P. Renard
Médecine/Sciences, 2002, 18, pp.169-180
Article dans une revue hal-02672187v1

Developmental potential of mouse embryos reconstructed from metaphase embryonic stem cell nuclei

Qi Zhou , Alice Jouneau , Vincent V. Brochard , Pierre Adenot , Jean Paul J. P. Renard
Biology of Reproduction, 2001, 65, pp.412-419
Article dans une revue hal-02674823v1

Heterogeneity in Epiblast Stem Cells

Alice Jouneau
Stem Cells Heterogeneity - Novel Concepts, 1123 (chapitre 2), Springer Nature, 225p, 2019, Advances in Experimental Medicine and Biology, ⟨10.1007/978-3-030-11096-3_2⟩
Chapitre d'ouvrage hal-02154640v1

From naive to primed pluripotency: In vitro conversion of mouse embryonic stem cells in epiblast stem cells

Matteo Tosolini , Alice Jouneau
Embryonic Stem Cell Protocols, 1341, Editions Springer, 449 p., 2016, Methods in Molecular Biology, 978-1-4939-2953-5. ⟨10.1007/7651_2015_208⟩
Chapitre d'ouvrage hal-02797501v1

Acquiring ground state pluripotency: Switching mouse embryonic stem cells from serum/LIF medium to 2i/LIF medium

Matteo Tosolini , Alice Jouneau
Embryonic Stem Cell Protocols, 1341, Editions Springer, 449 p., 2016, Methods in Molecular Biology, 978-1-4939-2953-5. ⟨10.1007/7651_2015_207⟩
Chapitre d'ouvrage hal-02797617v1

Whole-mount in situ hybridization to assess advancement of development and embryo morphology

Bernd Püschel , Alice Jouneau
Nuclear reprogramming: Methods and Protocols, 1222 (2 ed.), Editions Springer, 290 p., 2015, Methods in Molecular Biology, 978-1-4939-1593-4. ⟨10.1007/978-1-4939-1594-1_19⟩
Chapitre d'ouvrage hal-02798220v1

Reprogramming and pluripotency of epiblast stem cells

Anne-Clémence Veillard , Julien Maruotti , Alice Jouneau
Stem cells and cancer stem cells, 8, Springer Science+Business Media, pp.364, 2012, Stem Cells and Cancer Stem Cells, 978-94-007-4798-2. ⟨10.1007/978-94-007-4798-2_13⟩
Chapitre d'ouvrage hal-02807889v1