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Researcher identifiers



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Born in Paris (France) on February 13th, 1968


Address : UMR BREED Biologie du Developpement et Reproduction, Epigénétique, Environnement et Développement, INRAE

                    Domaine de Vilvert, 78352 Jouy en Josas Cedex, France

Scientific profile

My main project is to understand how pluripotency is established in the mammalian embryo and how it is controlled at the molecular and epigenetic levels. I have an internationally recognized expertise and more than 20 papers in mammalian embryo development and pluripotency in mammalian species. I have developed and used several approaches such as high throughput analyses (transcriptome and epigenome), cell biology and imaging, and in vitro derivation of cell lines from epiblast and trophoblast.


 Education & Professional experience

  • 1999- present : Research Scientist, project leader at INRAE, BREED
  • 2005-2007: Associate Professor of Chinese Academy of Sciences, The Sino-French (INRA/CAS) Laboratory LABIOCEM, Institute of Zoology, Beijing China
  • 1997-1999: Post-doctoral fellow, the Laboratory of Developmental Genetics of the Melanocytes, UMR 146, Institut Curie-Orsay, France
  • 1992-1996: PhD student, laboratory of Cellular morphogenesis and Tumor Progression,  UMR 144, Institut Curie-, France


Journal articles22 documents

  • Emma Bell, Edward W. Curry, Wout Megchelenbrink, Luc Jouneau, Vincent Brochard, et al.. Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency. Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-14916-7⟩. ⟨hal-02508171⟩
  • Guenhaël Sanz, Nathalie Daniel, Catherine Archilla, Luc Jouneau, Yan Jaszczyszyn, et al.. Differentiation of derived rabbit trophoblast stem cells under fluid shear stress to mimic the trophoblastic barrier. Biochimica Et Biophysica Acta. General Subjects, 2019, 1863, Issue 10, pp.1608-1618. ⟨10.1016/j.bbagen.2019.07.003⟩. ⟨hal-02183790⟩
  • René a M Dirks, Guido van Mierlo, Hindrik H D Kerstens, Andreia S Bernardo, Julianna Kobolak, et al.. Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states. Epigenetics and Chromatin, BioMed Central, 2019, 12 (1), pp.1-21. ⟨10.1186/s13072-019-0259-8⟩. ⟨hal-02625883⟩
  • Andreia S Bernardo, Alice Jouneau, Hendrik Marks, Philip Kensche, Julianna Kobolak, et al.. Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state.. Biology Open, Royal Society, 2018, ⟨10.1242/bio.033282⟩. ⟨hal-02623684⟩
  • Matteo Tosolini, Vincent Brochard, Pierre Adenot, Martine Chebrout, Giacomo Grillo, et al.. Contrasting epigenetic states of heterochromatin in the different types of mouse pluripotent stem cells. Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.14. ⟨10.1038/s41598-018-23822-4⟩. ⟨hal-02309000⟩
  • Eugenie Canon, Luc Jouneau, Thierry Blachère, Nathalie Peynot, Nathalie Daniel, et al.. Progressive methylation of POU5F1 regulatory regions during blastocyst development.. Reproduction -Cambridge- Supplement-, Society for Reproduction and Fertility, 2018, 156 (2), pp.145-161. ⟨10.1530/REP-17-0689⟩. ⟨hal-02623175⟩
  • Fabienne Nuttinck, Alice Jouneau, Gilles Charpigny, Isabelle Hue, Christophe Richard, et al.. Prosurvival effect of cumulus prostaglandin G/H synthase 2/prostaglandin2 signaling on bovine blastocyst: impact on in vivo posthatching development. Biology of Reproduction, Society for the Study of Reproduction, 2017, 96 (3), pp.531-541. ⟨10.1095/biolreprod.116.145367⟩. ⟨hal-01605027⟩
  • Caroline Sauvegarde, Delphine Paul, Laure Bridoux, Alice Jouneau, Severine Degrelle, et al.. Dynamic Pattern of HOXB9 Protein Localization during Oocyte Maturation and Early Embryonic Development in Mammals. PLoS ONE, Public Library of Science, 2016, 11 (10), pp.e0165898. ⟨10.1371/journal.pone.0165898⟩. ⟨inserm-02440442⟩
  • Anne-Clémence Veillard, Hendrik Marks, Andreia Sofia Bernardo, Luc Jouneau, Denis Laloë, et al.. Stable methylation at promoters distinguishes epiblast stem cells from embryonic stem cells and the in vivo epiblasts. Stem Cells and Development, Mary Ann Liebert, 2014, 23 (17), pp.2014-2029. ⟨10.1089/scd.2013.0639⟩. ⟨hal-01193858⟩
  • Costis Papanayotou, Ataaillah Benhaddou, Anne Camus, Aitana Perea-Gomez, Alice Jouneau, et al.. A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation.. PLoS Biology, Public Library of Science, 2014, 12 (6), pp.e1001890. ⟨10.1371/journal.pbio.1001890⟩. ⟨hal-01060190⟩
  • Barbara Panneau, Luc Jouneau, Pierre Osteil, Yann Tapponnier, Marielle Afanassieff, et al.. Contrasting transcriptome landscapes of rabbit pluripotent stem cells [i]in vitro[/i] and [i]in vivo[/i]. Animal Reproduction Science, Elsevier Masson, 2014, 149 (1-2), pp.67-79. ⟨10.1016/j.anireprosci.2014.05.014⟩. ⟨hal-01193859⟩
  • Thomas Fröhlich, Miwako Kösters, Alexander Graf, Eckhard Wolf, Julianna Kobolak, et al.. iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells. Journal of Proteomics, Elsevier, 2013, 90, pp.38-51. ⟨10.1016/j.jprot.2013.03.015⟩. ⟨hal-01190583⟩
  • Daulat-Raheem Khan, Delphine Dubé, Laurence Gall, Nathalie Peynot, Sylvie Ruffini, et al.. Expression of pluripotency master regulators during two key developmental transitions: EGA and early lineage specification in the bovine embryo. PLoS ONE, Public Library of Science, 2012, 7 (3), pp.1-12. ⟨10.1371/journal.pone.0034110⟩. ⟨hal-01000766⟩
  • Julien Maruotti, Marta Muñoz, Severine Degrelle, Enrique Gómez, Claire Louet, et al.. Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors: Nodal signaling and pluripotency in bovine epiblast. Molecular Reproduction and Development, Wiley, 2012, 79 (7), pp.461-77. ⟨10.1002/mrd.22051⟩. ⟨hal-01000771⟩
  • Laurence Gall, Vincent Brochard, Sylvie Ruffini, Ludivine Laffont, Renaud Fleurot, et al.. Intermediate filaments promote nuclear mechanical constraints during somatic cell nuclear transfer in the mouse. CELLULAR REPROGRAMMING, 2012, 14 (6), pp.497-504. ⟨10.1089/cell.2012.0027⟩. ⟨hal-01000765⟩
  • Alice Jouneau, Constance Ciaudo, Odile Sismeiro, Vincent Brochard, Luc Jouneau, et al.. Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles. RNA, Cold Spring Harbor Laboratory Press, 2012, 18 (2), pp.253-264. ⟨10.1261/rna.028878.111⟩. ⟨hal-01001312⟩
  • Daulat Raheem Khan, Delphine Dube, Laurence Gall, Nathalie Peynot, Sylvie Ruffini, et al.. Expression of Pluripotency Master Regulators during Two Key Developmental Transitions: EGA and Early Lineage Specification in the Bovine Embryo. PLoS ONE, Public Library of Science, 2012, 7 (3), pp.e34110. ⟨10.1371/journal.pone.0034110⟩. ⟨inserm-02440304⟩
  • Olivier Ganier, Stéphane Bocquet, Isabelle Peiffer, Vincent Brochard, Philippe Arnaud, et al.. Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2011, 108 (42), pp.17331-17336. ⟨10.1073/pnas.1100733108⟩. ⟨hal-01000287⟩
  • Tang Hai, Jie Hao, Liu Wang, Alice Jouneau, Qi Zhou. Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. CELLULAR REPROGRAMMING, 2011, 6 (9), pp.1149-1161. ⟨10.1089/cell.2010.0042⟩. ⟨hal-01001201⟩
  • Maite Rielland, Vincent Brochard, Marie-Christine Lacroix, Jean Paul Renard, Alice Jouneau. Early alteration of the self-renewal/differentiation threshold in trophoblast stem cells derived from mouse embryos after nuclear transfer. Developmental Biology, Elsevier, 2009, 334 (2), pp.325-334. ⟨10.1016/j.ydbio.2009.07.022⟩. ⟨hal-00490154⟩
  • Yang Yu, Chenhui Ding, Eryao Wang, Xinjie Chen, Xuemei Li, et al.. Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis. Reproduction, BioScientifica, 2007, 133 (5), pp.947-954. ⟨10.1530/REP-06-0358⟩. ⟨hal-02610680⟩
  • Alice Jouneau, Qi Zhou, Anne Camus, Vincent Brochard, Linda Maulny, et al.. Developmental abnormalities of NT mouse embryos appear early after implantation.. Development (Cambridge, England), Company of Biologists, 2006, 133, pp.1597-1607. ⟨10.1242/10.1242/dev.02317⟩. ⟨hal-00096257⟩

Book sections1 document

Conference papers15 documents

  • Nicolas M Ortega, Virpi Ahola, Pankaj Kumar, Alice Jouneau, Veronique Duranthon, et al.. Bovine preimplantation embryos at the single cell level: an accurate model for human reproductive approaches?. 2. CellFit Workshop 2019, CellFit. GBR., Mar 2019, Belgrade, Serbia. ⟨hal-02264368⟩
  • Alice Jouneau. Les différents états de pluripotence: Rôle des modifications épigénétiques dans la transition pluripotence naïve et amorcée. 1 ère réunion du réseau Stem-Phase, Jan 2019, Bron, France. ⟨hal-02786067⟩
  • Alice Jouneau, Véronique Azuara, Emma Bell, Ed Curry, Wout Megchelenbrink, et al.. Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naïve pluripotency. 3rd Annual Meeting, French Society for Stem Cell Research. Corbeil-Essonne, FRA., Nov 2019, Lyon, France. ⟨hal-02460141⟩
  • Mélanie Pailles, Vincent Brochard, Martine Chebrout, Pierre Adenot, Alice Jouneau, et al.. Heterochromatin as a pluripotency marker: Exploring H3K27me3 dynamic at pericentromeric heterochromatin in mouse peri-implantation embryos. FSSCR 3rd Annual Meeting, French Society for Stem Cell Research. FRA., Nov 2019, Lyon, France. ⟨hal-02475154⟩
  • Matteo Tosolini, Melanie Pailles, Vincent Brochard, Martine Chebrout, Amelie Bonnet-Garnier, et al.. Dynamic landscape of peri-cenromeric heterochromatin during transistion from naïve to primed pluripotency. Annual Meeting 2018 CellFit, CellFit. GBR., Oct 2018, Hvar island, Croatia. pp.109. ⟨hal-02734473⟩
  • Guenhael Sanz, Christophe Richard, Nathalie Daniel, Eve Mourier, Delphine Rousseau-Ralliard, et al.. Analyse des échanges transplacentaires par perfusion placentaire ex-vivo ou par des modèles cellulaires in vitro. Journées d'Animation Scientifique du Département PHASE, Apr 2018, Rennes, France. ⟨hal-02733989⟩
  • Alice Jouneau, Matteo Tosolini, Vincent Brochard, Pierre Adenot, Martine Chebrout, et al.. Contrasting epigenetic landscapes of heterochromatin in mouse pluripotent cells. Labex Revive: 6th Annual Consortium Meeting, Regenerative Biology & Medicine (REVIVE). FRA., 2017, Gouvieux, France. ⟨hal-02786605⟩
  • Alice Jouneau, Claire Louet, Vincent Brochard. Inter-species (mouse, pig, cow) comparison of pluripotency. 4th Annual Consortium meeting, REVIVE 2015, Regenerative Biology & Medicine (REVIVE). FRA., Jan 2015, Belle-Eglise, France. ⟨hal-02796527⟩
  • Anne-Clémence Veillard, Bernado Andreia, Audrey Prezelin, Laurent Boulanger, Vincent Brochard, et al.. Characterisation of DNA methylation in mouse epiblast stem cells (EpiSCs): comparison with the epiblast and with embryonic stem cells (ESCs). Conférence Jacques Monod, DNA methylation and demethylation, Centre National de la Recherche Scientifique (CNRS). FRA., Sep 2013, Roscoff, France. 1 p. ⟨hal-01019186⟩
  • Barbara Schmaltz-Panneau, Luc Jouneau, Nathalie Daniel, Pierre Osteil, Yann Tapponnier, et al.. Pluripotency : in embryo and [i][/i]in vitro[i][/i]. 4. Mammalian Embryo Genomics Meeting, Université Laval. CAN., Oct 2013, Hilton Quebec City, Canada. pp.24. ⟨hal-01019552⟩
  • Luc Jouneau, Marks Hendrik, Anne-Clémence Veillard, Anita Kaan, Henk Stunnenberg, et al.. Different patterns of gene body DNA methylation in ESC and EpiSC. Conférence Jacques Monod Méthylation et déméthylation de l'ADN, Centre National de la Recherche Scientifique (CNRS). FRA., Sep 2013, Roscoff, France. 1 p. ⟨hal-01019566⟩
  • Anne-Clémence Veillard, Andreia Bernado, Vincent Brochard, Luc Jouneau, Roger Pedersen, et al.. Comparison of DNA methylation between two types of mouse pluripotent stem cells: ESCs and EpiSCs. 2. REVIVE Consortium Meeting, Institut Pasteur [Paris]. FRA., Feb 2013, Belle Eglise, France. 1 p. ⟨hal-01019613⟩
  • A. Dinnyes, M.K. Pirity, E. Gocza, P. Osteil, Nathalie Daniel, et al.. Generation of rabbit pluripotent stem cell lines. 38. Annual Conference of the International Embryo Transfer Society, International Embryo Transfer Society (IETS). USA., Jan 2012, Phoenix, United States. pp.286, ⟨10.1071/RDv24n1Ab246⟩. ⟨hal-01004449⟩
  • Alice Jouneau, Maite Rielland, Claire Louet, Vincent Brochard, Hai Tang, et al.. Abnormal development of the trophoblast after nuclear transfer in the mouse. EMBO workshop:"Lineage commitments: Emphasis on the extraembryonic-embryonic interface", EMBO. Heidelberg, DEU., May 2011, Leuven, Belgium. 1 p. ⟨hal-01019065⟩
  • Anne-Clémence Veillard, Marks Hendrick, Luc Jouneau, Julien Maruotti, Helene Jammes, et al.. Epigenetic characterization of epiblast stem cells derived from fertilized and nuclear-transferred mouse embryos. 1. annual Cambridge Stem Cell international symposium: Pluripotency and Development, University of Cambridge [UK] (CAM). Cambridge, GBR., Jul 2011, Cambridge, United Kingdom. 1 p. ⟨hal-01019057⟩

Poster communications5 documents

  • Alice Jouneau. Les super-enhancers: des régions régulatrices dynamiques, plateformes d’interactions entre facteur de transcription, méthylation de l’ADN et structure de la chromatine. 5. Journée d'Animation Scientifique du réseau épiPhase, Jun 2019, Toulouse, France. 35 p., 2019, EpiPHASE. ⟨hal-02734833⟩
  • Guenhael Sanz, Nathalie Daniel, Vincent Brochard, Marie-Christine Aubrière, Martine Letheule, et al.. A new culture model of rabbit trophoblastic cells to explore cell function and transplacental transfers. Regenerative medicine: organoids and model species, Oct 2018, Paris, France. 2018. ⟨hal-02788443⟩
  • Guenhael Sanz, Nathalie Daniel, Vincent Brochard, Marie-Christine Aubrière, Martine Letheule, et al.. A new culture model of rabbit trophoblastic cells to explore cell function and transplacental transfers. Annual Meeting 2018 CellFit, Oct 2018, Hvar Island, Croatia. School of Medicine University of Zagreb, Editors Tiziana Brevini, Alireza Fazeli, Ana Katusic, Ana Vidos, Georgia May, pp.109, 2018, Proceedings of CellFit Meeting 2018 « in vitro 3-D Total Cell Guidance and fitness ». ⟨hal-02738050⟩
  • Matteo Tosolini, Vincent Brochard, Pierre Adenot, Martine Chebrout, Grillo Giacomo, et al.. Contrasted regulation of pericentromeric hetero chromatin in mouse ground naive and primed pluripotent stem cells. France-Japan Epigenetics Workshop 2017, Nov 2017, Paris, France. 2017. ⟨hal-02786601⟩
  • Alline de Paula Reis, Alain Trubuil, Alice Jouneau, Eugenie Canon, Ludivine Laffont, et al.. Morphokinetic and transcriptomic characterisation of bovine embryos: towards an improvment of the use of embryos for population recovery. Séminaire international CRB Anim, May 2017, Paris, France. 1p., 2017. ⟨hal-02790636⟩