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Journal articles46 documents

  • Mouna El Mehdi, Saloua Takhlidjt, Mélodie Devère, Arnaud Arabo, Marie-Anne Le Solliec, et al.. The 26RFa (QRFP)/GPR103 neuropeptidergic system in mice relays insulin signalling into the brain to regulate glucose homeostasis. Diabetologia, 2022, 65 (7), pp.1198-1211. ⟨10.1007/s00125-022-05706-5⟩. ⟨hal-03712879⟩
  • Selma Ben Fradj, Emmanuelle Nédélec, Juliette Salvi, Mélanie Fouesnard, Marine Huillet, et al.. Evidence for constitutive microbiota-dependent short-term control of food intake in mice: Is there a link with inflammation, oxidative stress, endotoxemia, and Glp-1?. Antioxidants and Redox Signaling, 2022, 37 (4-6), pp.349-369. ⟨10.1089/ars.2021.0095⟩. ⟨hal-03594297⟩
  • Tony Heurtaux, David S. Bouvier, Alexandre Benani, Sergio Helgueta Romero, Katrin B. M. Frauenknecht, et al.. Normal and Pathological NRF2 Signalling in the Central Nervous System. Antioxidants , 2022, 11 (8), pp.1426. ⟨10.3390/antiox11081426⟩. ⟨hal-03744948⟩
  • Juliette Salvi, Pierre Andreoletti, Etienne Audinat, Eglantine Balland, Selma Ben Fradj, et al.. Microgliosis: a double‐edged sword in the control of food intake. FEBS Journal, In press, pp.16583. ⟨10.1111/febs.16583⟩. ⟨hal-03739689⟩
  • Selma Ben Fradj, Emmanuelle Nédélec, Juliette Salvi, Mélanie Fouesnard, Marine Huillet, et al.. Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1?. Antioxidants and Redox Signaling, 2022, 37 (4-6), pp.349-369. ⟨10.1089/ars.2021.0095⟩. ⟨hal-03874609⟩
  • Marie-Anne Le Solliec, Arnaud Arabo, Saloua Takhlidjt, Julie Maucotel, Melodie Devère, et al.. Acute but not chronic central administration of the neuropeptide 26RFa (QRFP) improves glucose homeostasis in obese/diabetic mice. Neuroendocrinology, 2022, 112 (11), pp.1104-1115. ⟨10.1159/000522287⟩. ⟨hal-03564780⟩
  • Tiffany Fougeray, Arnaud Polizzi, Marion Régnier, Anne Fougerat, Sandrine Ellero-Simatos, et al.. The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression. Cell Reports, 2022, 39 (2), pp.110674. ⟨10.1016/j.celrep.2022.110674⟩. ⟨hal-03647009⟩
  • Mélanie Fouesnard, Johanna Zoppi, Mélanie Pétéra, Léa Le Gleau, Carole Migné, et al.. Dietary switch to Western diet induces hypothalamic adaptation associated with gut microbiota dysbiosis in rats. International Journal of Obesity, 2021, 45 (6), pp.1271-1283. ⟨10.1038/s41366-021-00796-4⟩. ⟨hal-03171983⟩
  • M.A. Le Solliec, J. Maucotel, A. Arabo, S. Takhlidjt, M. Picot, et al.. Évaluation des effets centraux du neuropeptide 26RFa sur la régulation de la glycémie chez la souris high fat diet. Annales d'Endocrinologie, 2021, 82 (5), pp.267. ⟨10.1016/j.ando.2021.08.040⟩. ⟨hal-03793302⟩
  • Céline Cansell, Katharina Stobbe, Clara Sanchez, Ophélia Le Thuc, Coralie-Anne Mosser, et al.. Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice. Glia, 2021, 69 (1), pp.42-60. ⟨10.1002/glia.23882⟩. ⟨hal-02899910⟩
  • Mouna El-Mehdi, Saloua Takhlidjt, Fayrouz Khiar, Gaëtan Prévost, Jean-Luc Do Rego, et al.. Glucose homeostasis is impaired in mice deficient in the neuropeptide 26RFa (QRFP). BMJ Open Diab Res Care, 2020, 8 (1), pp.2019-000942. ⟨10.1136/bmjdrc-2019-000942⟩. ⟨hal-02884077⟩
  • Danae Nuzzaci, Céline Cansell, Fabienne Liénard, Emmanuelle Nédélec, Selma Ben Fradj, et al.. Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal. Cell Reports, 2020, 30 (9), pp.3067-3078.e5. ⟨10.1016/j.celrep.2020.02.029⟩. ⟨hal-02520973⟩
  • Nanette Schneider, Sylvie Chaudy, Alberto L. Epstein, Cécile Viollet, Alexandre Benani, et al.. Centrifugal projections to the main olfactory bulb revealed by trans‐synaptic retrograde tracing in mice. Journal of Comparative Neurology, 2020, 528 (11), pp.1805-1819. ⟨10.1002/cne.24846⟩. ⟨hal-02620936⟩
  • Gaëtan Prévost, Arnaud Arabo, Marie-Anne Le Solliec, Justine Bons, Marie Picot, et al.. Neuropeptide 26RFa (QRFP) is a key regulator of glucose homeostasis and its activity is markedly altered in obese/hyperglycemic mice. AJP - Endocrinology and Metabolism, 2019, 317 (1), pp.E147-E157. ⟨10.1152/ajpendo.00540.2018⟩. ⟨hal-02330443⟩
  • Gaëtan Prévost, Marie Picot, Marie-Anne Le Solliec, Arnaud Arabo, Hind Berrahmoune, et al.. The neuropeptide 26RFa in the human gut and pancreas: potential involvement in glucose homeostasis. Endocrine Connections, 2019, 8 (7), pp.941-951. ⟨10.1530/ec-19-0247⟩. ⟨hal-02330439⟩
  • Frédéric Jehl, Colette Désert, Christophe C. Klopp, Mathias Brenet, Andrea Rau, et al.. Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach. BMC Genomics, 2019, 20 (1), ⟨10.1186/s12864-019-6384-8⟩. ⟨hal-02463367⟩
  • Xavier Brenachot, Emmanuelle Nedelec, Selma Ben Fradj, Gaëlle Boudry, Veronique Douard, et al.. Lack of Hypothalamus Polysialylation Inducibility Correlates With Maladaptive Eating Behaviors and Predisposition to Obesity. Frontiers in nutrition, 2018, 5, pp.125. ⟨10.3389/fnut.2018.00125⟩. ⟨hal-01998042⟩
  • Chloé Chrétien, Claire Fenech, Fabienne Liénard, Sylvie Grall, Charlène Chevalier, et al.. Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis. Diabetes, 2017, 66 (2), pp.314 - 324. ⟨10.2337/db16-1114⟩. ⟨hal-01477491⟩
  • Xavier Brenachot, Thomas Gautier, Emmanuelle Nédélec, Valérie Deckert, Amélie Laderrière, et al.. Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus.. Frontiers in Neuroscience, 2017, 11, pp.245. ⟨10.3389/fnins.2017.00245⟩. ⟨hal-01541079⟩
  • Luc Pénicaud, Alexandre Benani, Xavier Brenachot, Chloé Chrétien, Lionel Carneiro, et al.. Détection cérébrale du glucose, plasticité neuronale et métabolisme énergétique. Cahiers de Nutrition et de Diététique, 2017, 52 (1), pp.19-25. ⟨10.1016/j.cnd.2016.09.006⟩. ⟨hal-02623095⟩
  • Danaé Nuzzaci, Amélie Laderrière, Aleth Lemoine, Emmanuelle Nedelec, Luc Pénicaud, et al.. Plasticity of the melanocortin system: Determinants and possible consequences on food intake. Frontiers in Endocrinology, 2015, 6 (article 143), pp.1-8. ⟨10.3389/fendo.2015.00143⟩. ⟨hal-01220062⟩
  • Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol, Xavier Brenachot, Laurent Parry, et al.. Hypothalamic eIF2 alpha signaling regulates food intake. Cell Reports, 2014, 6 (3), pp.438-444. ⟨10.1016/j.celrep.2014.01.006⟩. ⟨hal-02635326⟩
  • Anne Drougard, Thibaut Duparc, Xavier Brenachot, Lionel Carneiro, Alexandra Gouazé, et al.. Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes. Antioxidants and Redox Signaling, 2014, 20 (4), pp.557 - 573. ⟨10.1089/ars.2013.5182⟩. ⟨hal-01211084⟩
  • Xavier Brenachot, Caroline Rigault, Emmanuelle Nedelec, Amélie Laderrière, Tasneem Khanam, et al.. The histone acetyltransferase MOF activates hypothalamic polysialylation to prevent diet-induced obesity in mice. Molecular metabolism, 2014, 3 (6), pp.619-629. ⟨10.1016/j.molmet.2014.05.006⟩. ⟨hal-01185024⟩
  • Alexandra Gouazé, Xavier Brenachot, Caroline Rigault, Alice Krezymon, Camille Rauche, et al.. Cerebral cell renewal in adult mice controls the onset of obesity.. PLoS ONE, 2013, 8 (8), pp.e72029. ⟨10.1371/journal.pone.0072029⟩. ⟨hal-00866271⟩
  • Caroline Rigault, Françoise Le Borgne, Bassim Tazir, Alexandre Benani, Jean Demarquoy. A high-fat diet increases l-carnitine synthesis through a differential maturation of the Bbox1 mRNAs.. BBA - Biochimica et Biophysica Acta, 2013, 1831 (2), pp.370-7. ⟨10.1016/j.bbalip.2012.10.007⟩. ⟨hal-00787886⟩
  • Camille Attané, Camille Foussal, Sophie Le Gonidec, Alexandre Benani, Danièle Daviaud, et al.. Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice.. Diabetes, 2012, 61 (2), pp.310-20. ⟨10.2337/db11-0100⟩. ⟨hal-00723095⟩
  • A. Gouaze, X. Brenachot, C. Rigault, A. Krezymon, S. Bauer, et al.. Early effects of high-fat diet on hypothalamic cell proliferation. Fundamental & Clinical Pharmacology, 2012, 26 (S1), pp.32-32 (meeting abstract 26-O051). ⟨hal-00723325⟩
  • Marta Amigó-Correig, Sílvia Barceló-Batllori, Guadalupe Soria, Alice Krezymon, Alexandre Benani, et al.. Anti-obesity sodium tungstate treatment triggers axonal and glial plasticity in hypothalamic feeding centers.. PLoS ONE, 2012, 7 (7), pp.e39087. ⟨10.1371/journal.pone.0039087⟩. ⟨hal-00723092⟩
  • Valéry Matarazzo, Fabienne Schaller, Emmanuelle Nédélec, Alexandre Benani, Luc Pénicaud, et al.. Inactivation of Socs3 in the hypothalamus enhances the hindbrain response to endogenous satiety signals via oxytocin signaling. Journal of Neuroscience, 2012, 32 (48), pp.17097-17107. ⟨10.1523/JNEUROSCI.1669-12.2012⟩. ⟨hal-01129683⟩
  • Jean Gascuel, Aleth Lemoine, Caroline Rigault, Frédérique Datiche, Alexandre Benani, et al.. Hypothalamus-olfactory system crosstalk: orexin a immunostaining in mice.. Frontiers in Neuroanatomy, 2012, 6, pp.44. ⟨10.3389/fnana.2012.00044⟩. ⟨hal-00787862⟩
  • Alexandre Benani, Cécile Hryhorczuk, Alexandra Gouazé, Xavier Fioramonti, Xavier Brenachot, et al.. Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice.. Journal of Neuroscience, 2012, 32 (35), pp.11970-9. ⟨10.1523/JNEUROSCI.0624-12.2012⟩. ⟨hal-00760988⟩
  • Corinne Leloup, Louis Casteilla, Audrey Carrière, Anne Galinier, Alexandre Benani, et al.. Balancing mitochondrial redox signaling: a key point in metabolic regulation.. Antioxidants and Redox Signaling, 2011, 14 (3), pp.519-30. ⟨10.1089/ars.2010.3424⟩. ⟨hal-00824690⟩
  • Bérengère Coupé, Valérie Amarger, Isabelle Grit, Alexandre Benani, Patricia Parnet. Nutritional Programming Affects Hypothalamic Organization and Early Response to Leptin. Neuroendocrinology, 2010, 151 (2), pp.702-713. ⟨10.1210/en.2009-0893⟩. ⟨hal-00452851⟩
  • Alexandre Benani, Valentin Barquissau, Lionel Carneiro, Bénédicte Salin, Anne-Laure Colombani, et al.. Method for functional study of mitochondria in rat hypothalamus. Journal of Neuroscience Methods, 2009, 178 (2), pp.301-7. ⟨hal-00455122⟩
  • Maria Carmen Carmona, Philippe Lefebvre, Bruno Lefebvre, Anne Galinier, Alexandre Benani, et al.. Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice. International Journal of Obesity, 2009, 33 (2), pp.204-11. ⟨10.1038/ijo.2008.265⟩. ⟨hal-00462260⟩
  • Tristan Jaillard, M. Roger, Anne Galinier, P. Guillou, Alexandre Benani, et al.. Hypothalamic reactive oxygen species are required for insulin-induced food intake inhibition: an NADPH oxidase-dependent mechanism. Diabetes, 2009, 58 (7), pp.1544-9. ⟨hal-00461354⟩
  • Alexandre Benani, V. Barquissau, L. Carneiro, B. Salin, A.L. Colombani, et al.. Methods for functional study of mitochondria inrat hypothalamus. Journal of Neuroscience Methods, 2009, 178 (2), pp.301-7. ⟨hal-00374046⟩
  • Anne-Laure Colombani, Lionel Carneiro, Alexandre Benani, Anne Galinier, Tristan Jaillard, et al.. Enhanced hypothalamic glucose sensing in obesity: alteration of redox signalling. Diabetes, 2009, 58 (10), pp.2189-97. ⟨hal-00461351⟩
  • Claude Knauf, Patrice D. Cani, Afifa Ait-Belgnaoui, Alexandre Benani, Cédric Dray, et al.. Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure.. Endocrinology, 2008, 149 (10), pp.4768-77. ⟨10.1210/en.2008-0180⟩. ⟨inserm-00409099⟩
  • Alexandre Benani, V. Barquissau, L. Carneiro, B. Salin, A.L. Colombani, et al.. Method for functional study of mitochondria in rat hypothalamus. Journal of Neuroscience Methods, 2008, sous presse, pp.00-00. ⟨hal-00358509⟩
  • Alexandre Benani, Stéphanie Troy, Maria Carmen Carmona, Xavier Fioramonti, Anne Lorsignol, et al.. Role for mitochondrial reactive oxygen species in brain lipid sensing: redox regulation of food intake. Diabetes, 2007, 56 (1), pp.152-60. ⟨hal-00462259⟩
  • C. Leloup, Christophe Magnan, Alexandre Benani, E. Bonnet, T. Alquier, et al.. Mitochondrial reactive oxygen spieces are required for hypothalamic glucose sensing.. Diabetes, 2006, 55(7), pp.2084-90. ⟨hal-00091714⟩
  • C. Leloup, C. Magnan, Alexandre Benani, E. Bonnet, T. Alquier, et al.. Mitochondrial Reactive Oxygen Species Are Required for Hypothalamic Glucose Sensing. Diabetes, 2006, 55 (7), pp.2084-2090. ⟨10.2337/db06-0086⟩. ⟨hal-03059945⟩
  • Mikaël Daouphars, Meriem Koufany, Alexandre Benani, Sophie Marchal, Jean-Louis Merlin, et al.. Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells.. International Journal of Oncology, 2005, 26, pp.1069-1077. ⟨hal-01778111⟩
  • Jean-Yves Jouzeau, Mikaël Daouphars, Alexandre Benani, Patrick Netter. Pharmacology and classification of cyclooxygenase inhibitors.. Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 2004, 28 (hors série III), pp.C7-17. ⟨hal-01778140⟩

Conference papers13 documents

  • Alexandre Benani. Exploration fonctionnelle du système neuronal à mélanocortine et corrélats comportementaux chez le rongeur. Journée Neurosciences "Bases neurobiologiques des comportements : Exploration fonctionnelle du cerveau", Mar 2022, Dijon, France. ⟨hal-03654036⟩
  • Alexandre Benani. Toward a link between brain plasticity and satiety. Symposium "Central Nervous System contributions to nutrition and obesity" [Diabetes and Metabolism Seminar series], NORC (Nutrition Obesity Research Center), Apr 2021, Washington, District of Columbia, United States. ⟨hal-03256909⟩
  • Marie-Anne Le Solliec, Julie Maucotel, Aranaud Arabo, Marie Picot, Saloua Takhlidjt, et al.. Evaluation of the 26RFa/GPR103 peptidergic system in a mouse model of insulinopenia. 57. annual meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Sep 2021, Virtual meeting, France. 1 p. ⟨hal-03368831⟩
  • Alexandre Benani. Pourquoi j'ai encore faim ?. La semaine du Cerveau, Mar 2019, Nancy, France. ⟨hal-02785925⟩
  • Bruno Patris, Amélie Laderrière, Danaé Nuzzaci, Emmanuelle Nédélec, Aleth Lemoine, et al.. Une alimentation maternelle enrichie en gras pendant la gestation et l’allaitement oriente le nouveau-né vers un lait produit sous régime gras (modèle murin). 41. colloque de la société de Neuroendocrinologie, Oct 2016, Corte (Corse), France. ⟨hal-03664643⟩
  • Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol-Desmet, Xavier Brenachot, Laurent Parry, et al.. Hypothalamic eIF2 alpha signaling regulates food intake. Assises du département Alimh, Jan 2014, Arêches, France. n.p. ⟨hal-01065490⟩
  • Sylvia Ortega Martinez, Sylvie Chaudy, Aleth Lemoine, Emmanuelle Nedelec, Kheira Bettayeb, et al.. Crosstalk between hypothalamic neurons and olfactory system: a tracing and anatomo-fuctional investigation in mouse. 24. Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Sep 2014, Dijon, France. 2 p. ⟨hal-01234399⟩
  • Gérard Coureaud, Marie-Chantal Canivenc-Lavier, Alexandre Benani, Jean-Philippe Charles, Frédérique Datiche, et al.. Comportement alimentaire. Journées Qualiment, Jun 2012, Dijon, France. ⟨hal-00723354⟩
  • C. Attané, C. Foussal, S. Le Gonidec, Alexandre Benani, D. Daviaud, et al.. Un traitement chronique à l'apeline chez la souris obèse et résistante à l'insuline augmente l'oxydation des acides gras et la biogénèse mitochondriale dans le muscle. 9èmes Journées Francophones de Nutrition - JFN, Dec 2011, Reims, France. ⟨hal-00816614⟩
  • Sylvie Bauer, Valéry Matarazzo, Fabienne Schaller, Alexandre Benani, Emmanuelle Nédélec, et al.. Hypothalamus-specific deletion of socs3 in adult mice enhances hindbrain sensitivity to endogenous satiety signals via oxytocin signaling. 10. Colloque de la Société des Neurosciences, May 2011, Marseille, France. ⟨hal-00832355⟩
  • Alexandre Benani, Alexandra Cornu, Alice Krezymon, Luc Pénicaud. High fat diet rapidly induces brain-plasticity-related transcriptomic signature in hypothalamus: role in energy homeostasis. Federation of European Neurosciences Societies (FENS), Jul 2010, Amsterdam, Netherlands. ⟨hal-00850800⟩
  • Lionel Carneiro, Geraldine Offer, Alexandre Benani, Pascale Belenguer, Luc Pénicaud, et al.. P244 Espèces actives de l'oxygène et détection cérébrale du glucose : implication de la dynamique mitochondriale. Congrès SFD 2009, Mar 2009, Strasbourg, France. pp.A84-A85, ⟨10.1016/S1262-3636(09)72042-7⟩. ⟨hal-00392590⟩
  • Tristan Jaillard, M. Roger, P. Guillou, Alexandre Benani, Louis Casteilla, et al.. Insulin differently modulates hypothalamic mitochondrial energy metabolism in fed or fasted mice: Involvement in food intake regulation?. ?, 2008, France. pp.374. ⟨hal-00452847⟩

Conference poster5 documents

  • Bruno Patris, Magali Tassone-Klaey, Amélie Laderrière, Danaé Nuzzaci, Emmanuelle Nédélec, et al.. Une alimentation maternelle enrichie en gras pendant la gestation ou l’allaitement oriente les préférences du souriceau vers un aliment gras à la naissance et au sevrage. 42. Colloque de la Société de Neuroendocrinologie, Sep 2017, Dijon, France. , 1 p., 2017. ⟨hal-02791099⟩
  • Xavier Fioramonti, Niyazi Acar, Lionel Brétillon, Claire Fenech, Frédérique Datiche, et al.. Intégration centrale de la perception sensorielle associée à l’alimentation. Journées qualiment, Jun 2012, Dijon, France. , 1 p., 2012. ⟨hal-02810362⟩
  • Gérard Coureaud, Marie-Chantal Canivenc Lavier, Alexandre Benani, Jean Philippe Charles, Frédérique Datiche, et al.. Comportement alimentaire. Journées qualiment, Jun 2012, Dijon, France. 1 p., 2012. ⟨hal-02810995⟩
  • S. Bauer, V. Matarazzo, F. Schaller, Alexandre Benani, Emmanuelle Nédélec, et al.. Hypothalamus-specific deletion of socs3 in adult mice enhances hindbrain sensitivity to endogenous satiety signals via oxytocin signaling. 10. Colloque de la Société des Neurosciences, 2011, Marseille, France. 1 p., 2011. ⟨hal-02807327⟩
  • Alexandre Benani, Alexandra Cornu, A. Krezymon, Luc Pénicaud. High fat diet rapidly induces brain-plasticity-related transcriptomic signature in hypothalamus: role in energy homeostasis. Federation of European Neurosciences Societies (FENS), Jul 2010, Amsterdam, Netherlands. , 1 p., 2010. ⟨hal-02817308⟩

Theses1 document

  • Alexandre Benani. Exploration fonctionnelle chez le rat des récepteurs activés par les proliférateurs de peroxysomes (PPAR) spinaux, cibles pharmacologiques potentielles dans les douleurs inflammatoires. Sciences pharmaceutiques. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN11310⟩. ⟨tel-01746921⟩

Videos1 document

  • Alexandre Benani. Vers un lien entre plasticité du cerveau et satiété. 2021. ⟨hal-03616148⟩