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27

CV Alexandre Legros


My scientific interests relate to the impact and the implications of specific electric and/or magnetic non-invasive stimulations applied to the human brain. These stimulations can be delivered using different modalities such as Transcranial Magnetic Stimulation (TMS), transcranial Direct or Alternating Electric Stimulation (tDCS or tACS), or via experimental technologies using time-varying magnetic fields to induce electric fields able to modulate endogenous physiological electric activity in brain structures. I terms of outcomes, I have thoroughly studied the impact of these stimulations on various aspects of human motor control (voluntary and involuntary), cognitive functions (memory and attention) and neurophysiological responses (e.g. Electroencephalography – EEG. In current projects supported by several industry partners (Hydro-Quebec, Electricité de France - EDF, Réseaux de Transport d’électricité – RTE, the Electric Power Research Institute – EPRI, the Central Research Institute of Electric Power Industry – CRIEPI ; coordinating this international Utilities Threshold Initiative Consortium – UTIC) and conducted in synergy between Canada and France (EuroMov, University of Montpellier), we are investigating the threshold and underlying action mechanisms for acute non-invasive neurostimulation applied either electrically or magnetically. We are studying visual (retinal magnetophospnes), vestibular (balance and vestibulo-ocular responses), EEG (using source reconstruction and source connectivity) and fMRI outcomes in order to establish the minimum stimuli intensity for a given frequency able to trigger a neural, perceptive or a behavioral response. We are also using computational neurosciences to model what sort of stimulus will induce what sort of response on different configurations of neural networks.  The primary purpose of this research is to help provide more accurate and evidence-based guidelines regarding EMF exposure, for both electricity producers and international regulatory bodies. A secondary objective is to explore the potential of using low intensity time-varying electric and magnetic stimuli for translational/therapeutic applications. In regards of the health protection aspects, I am currently co-chairing the subcommittee 3 of IEEE-ICES (exposures limits for 0-3kHz) and in charge of the working group on ‘Merging computational and experimental approaches to resolve uncertainties related to electrostimulation threshold’ within the IEEE ICES subcommittee 6: EMF dosimetry modeling with application to human exposure standards.  


Journal articles11 documents

  • P. Khuntia, Matias Velázquez, Quentin Barthélemy, Fabrice Bert, Edwin Kermarrec, et al.. Gapless ground state in the archetypal quantum kagome antiferromagnet ZnCu3(OH)6Cl2. Nature Physics, Nature Publishing Group, 2020, 16 (4), pp.469-474. ⟨10.1038/s41567-020-0792-1⟩. ⟨hal-02624312⟩
  • Julien Modolo, Mahmoud Hassan, Giulio Ruffini, Alexandre Legros. Probing the circuits of conscious perception with magnetophosphenes. Journal of Neural Engineering, IOP Publishing, 2020, 17 (3), pp.036034. ⟨10.1088/1741-2552/ab97f7⟩. ⟨hal-02798352⟩
  • A. Legros, B. Loret, A. Forget, P. Bonnaillie, G. Collin, et al.. Crystal growth and doping control of HgBa2CuO4+δ, the model compound for high-T superconductors. Materials Research Bulletin, Elsevier, 2019, 118, pp.110479. ⟨10.1016/j.materresbull.2019.05.004⟩. ⟨cea-02145955⟩
  • A. Legros, S. Benhabib, W. Tabis, F. Laliberté, M. Dion, et al.. Universal $T$-linear resistivity and Planckian dissipation in overdoped cuprates. Nature Physics, Nature Publishing Group, 2019, 15 (2), pp.142-147. ⟨10.1038/s41567-018-0334-2⟩. ⟨cea-02086419⟩
  • Legros A., Benhabib S., Tabis W., Laliberte F., Dion M., et al.. Universal T-linear resistivity and Planckian dissipation in overdoped cuprates. Nature Physics, Nature Publishing Group, 2019, ⟨10.1038/s41567-018-0334-2⟩. ⟨hal-02443843⟩
  • Julien Modolo, Alex W. Thomas, Alexandre Legros. Human exposure to power frequency magnetic fields up to 7.6 mT: An integrated EEG/fMRI study. Bioelectromagnetics, Wiley, 2017, 38 (6), pp.425-435. ⟨10.1002/bem.22064⟩. ⟨hal-01579726⟩
  • S.D. Jazi, Julien Modolo, C. Baker, S. Villard, A. Legros. Effects of a 60 Hz magnetic field of up to 50 millitesla on human tremor and EEG: A pilot study. International Journal of Environmental Research and Public Health, MDPI, 2017, 14 (12), pp.1446. ⟨10.3390/ijerph14121446⟩. ⟨hal-01671692⟩
  • A.N. Pavlov, A.N. Tupitsyn, A. Legros, A. Beuter, E. Mosekilde. Using wavelet analysis to detect the influence of low frequency magnetic fields on human physiological tremor. Physiologcial Measurement, 2007, 28 (3), pp.321-333. ⟨hal-00401063⟩
  • A. Legros, P. Gaillot, A. Beuter. Transient effect of low intensity magnetic field on human motor behavior. Medical Engineering and Physics, Elsevier, 2006, 28 (8), pp.827-836. ⟨hal-00401056⟩
  • A. Legros, A. Beuter. Individual subject sensitivity to extremely low frequency magnetic field. NeuroToxicology, Elsevier, 2006, 27 (4), pp.534-546. ⟨hal-00401053⟩
  • A. Legros, A. Beuter. Effect of a low intensity magnetic field on human motor behavior. Bioelectromagnetics, Wiley, 2005, 26 (8), pp.657-669. ⟨hal-00401035⟩

Conference papers14 documents

  • A. Legros, D. Goulet, M. Plante, G. Ostiguy, Julien Modolo, et al.. Human acute neurophysiological perceptions associated with ELF flux densities up to 50 mT. 2019 IEEE Radio and Antenna Days of the Indian Ocean, RADIO 2019, Sep 2019, Reunion Island, France. pp.8968916, ⟨10.23919/RADIO46463.2019.8968916⟩. ⟨hal-02535135⟩
  • Julien Modolo, Mahmoud Hassan, Alexandre Legros. Reconstruction of brain networks involved in magnetophosphene perception using dense electroencephalography. BioEM2018, Jun 2018, Portorož, Slovenia. ⟨hal-01736007⟩
  • M. Corbacio, A. G. Legros, A. Beuter, J. Weller, S. Dubois, et al.. Effects of a Power-line Frequency Magnetic Field on Human Cognitive Processing: Preliminary Results. Lawson Research Day, Mar 2009, London, Canada. ⟨hal-00401310⟩
  • A. Legros, D. Mcnamee, A. Beuter, S. Brown, S. Dubois, et al.. Physiological and neuro-behavioral effects of an exposure to a 60 Hz magnetic field at 1800 microtesla. Bioelectromagnetics Society, Jun 2008, San Diego, United States. ⟨hal-00401302⟩
  • A. Legros, D. Mcnamee, A. Beuter, D. Goulet, M. Plante, et al.. Power-Line frequency Magnetic Fields Effects on Human Neurophysiology and Motor Behaviors. URSI International Union of Radio Science, Jul 2007, Ottawa, Canada. ⟨hal-00401227⟩
  • A. Legros, D. Mcnamee, A. Beuter, D. Goulet, M. Plante, et al.. Human acute exposure to a 60 Hz, 1800 microtesla magnetic field: physiological, neurophysiological and behavioral effects. The Bioelectromagnetics Society, Jun 2007, Kanazawa, Japan. ⟨hal-00401230⟩
  • A. Legros, A. Beuter, D. Goulet, M. Plante, Fs Prato, et al.. Biophysical effects of a 60 Hz Magnetic field: from neurophysiology to motor behaviour. Bioelectromagnetism Society, Jun 2006, Cancun, Mexico. ⟨hal-00401206⟩
  • C. Geny, A. Legros, M. Charif, V. Gonzales, G. Garrigues, et al.. Analyse cinématique de la bradykinésie des syndromes parkinsoniens : étude préliminaire. Société de Neurologie, 2006, Genève, Suisse. ⟨hal-00401209⟩
  • A. Legros, A. Beuter, D. Goulet, M. Plante, F. S Prato, et al.. Proposal to study biophysical effects of a 60 Hz magnetic field: From neurophysiology to motor behaviors. The Bioelectromagnetics Society, Jun 2006, Cancun, Mexico. ⟨hal-00401180⟩
  • A. Legros, A. Beuter, L. Keenliside, D. Goulet, M. Plante, et al.. Neurophysiological and behavioral effects of human acute exposure to a 60 Hz magnetic field up to 1800 µT: Preliminary results. 4th Workshop on Biological Effects of Electromagnetic Fields, Oct 2006, Demokritos, Greece. ⟨hal-00401171⟩
  • C. Geny, A. Legros, M. Charif, V. Gonzales, G. Garrigues, et al.. Analyse cinématique de la bradykinésie des syndromes parkinsoniens. Journées Neurologiques de Langue Française, Apr 2006, Toulouse, France. ⟨hal-00401159⟩
  • A. Legros, A. Beuter. L'exposition à un champ magnétique de 1000 µT à 50 Hz peut-elle être détectée dans le tremblement physiologique humain ?. Société Française de Radioprotection, Jun 2005, Nantes, France. ⟨hal-00401120⟩
  • A. Legros, P. Gaillot, D. Nguyen, D. Goulet, M. Plante, et al.. Could a 50 Hz, 1000 µT magnetic field have a transient effect on human physiological tremor?. The Bioelectromagnetics Society, Jun 2005, Dublin, Ireland. ⟨hal-00401116⟩
  • A. Legros, P. Gaillot, D. Nguyen, D. Goulet, M. Plante, et al.. Could human physiological tremor be transiently modified by the switch of a 50 Hz, 1000 µT MF?. Bioelectromagnetism Society, Jun 2005, Dublin, Ireland. ⟨hal-00401154⟩

Preprints, Working Papers, ...2 documents

  • M. -E. Boulanger, G. -Q. Zheng, M. Lizaire, A. Legros, A. Gourgout, et al.. Transport signatures of the pseudogap critical point in the cuprate superconductor Bi 2 Sr 2−x La x CuO 6+δ. 2020. ⟨hal-03060548⟩
  • Julien Modolo, Mahmoud Hassan, Alexandre Legros. MAGNETOPHOSPHENES: ETUDE DES MECANISMES PAR ELECTROENCEPHALOGRAPHIE HAUTE RESOLUTION. 2018. ⟨hal-01766503⟩