Alexandre Harlé

Heloïse Pina, Julia Salleron, Pauline Gilson, Marie Husson, Marie Rouyer, et al.. Intraoperative prediction of non‑sentinel lymph node metastases in breast cancer using cytokeratin 19 mRNA copy number: A retrospective analysis. Molecular and Clinical Oncology, Spandidos Publications, 2022, 16 (3), pp.58. ⟨10.3892/mco.2022.2491⟩. ⟨hal-03538820⟩

Alexandre Harlé, Pauline Gilson, Jean-Louis Merlin. Detection of microsatellite instability: State of the art and future applications in circulating tumour DNA (ctDNA). Cancers, MDPI, 2021, 13 (7), pp.1491. ⟨10.3390/cancers13071491⟩. ⟨hal-03408458⟩

Alexandre Harlé, Pauline Gilson, Chloé Saurel, Julia Salleron, Marie Husson, et al.. Evaluation of the Idylla ctEGFR mutation assay to detect EGFR mutations in plasma from patients with non-small cell lung cancers. Scientific Reports, Nature Publishing Group, 2021, 11, pp.10470. ⟨10.1038/s41598-021-90091-z⟩. ⟨hal-03408465⟩

Julie Dardare, Andréa Witz, Jean-Louis Merlin, Agathe Bochnakian, Paul Toussaint, et al.. Epithelial to mesenchymal transition in patients with pancreatic ductal adenocarcinoma: State-of-the-art and therapeutic opportunities. Pharmaceuticals, MDPI, 2021, 14 (8), pp.740. ⟨10.3390/ph14080740⟩. ⟨hal-03408471⟩

Xavier Sastre-Garau, Mamadou Diop, Fernando Martin, Gilles Dolivet, Frédéric Marchal, et al.. A NGS-based blood test for the diagnosis of invasive HPV-associated carcinomas with extensive viral genomic characterization. Clinical Cancer Research, American Association for Cancer Research, 2021, 27 (19), pp.5307-5316. ⟨10.1158/1078-0432.CCR-21-0293⟩. ⟨hal-03408468⟩

Florence Koeppel, Etienne Muller, Alexandre Harlé, Celine Guien, Pierre Sujobert, et al.. Standardisation of pathogenicity classification for somatic alterations in solid tumours and haematologic malignancies. European Journal of Cancer, Elsevier, 2021, 159, pp.1-15. ⟨10.1016/j.ejca.2021.08.047⟩. ⟨hal-03408473⟩

Jacques Thomas, Léa Leufflen, Virginie Chesnais, Ségolène Diry, Jessica Demange, et al.. Identification of specific tumor markers in vulvar carcinoma through extensive human papillomavirus DNA characterization using next generation sequencing method. Journal of Lower Genital Tract Disease, Wiley-Blackwell: No OnlineOpen, 2020, 24 (1), pp.53-60. ⟨10.1097/LGT.0000000000000498⟩. ⟨hal-02425858⟩

Xavier Sastre-Garau, Alexandre Harlé. Pathology of HPV-associated head and neck carcinomas: Recent data and perspectives for the development of specific tumor markers. Frontiers in Oncology, Frontiers, 2020, 10, pp.528957. ⟨10.3389/fonc.2020.528957⟩. ⟨hal-03079066⟩

Voreak Suybeng, Florence Koeppel, Alexandre Harlé, Etienne Rouleau. Comparison of pathogenicity prediction tools on somatic variants. Journal of Molecular Diagnostics, American Society for Investigative Pathology (ASIP), 2020, 22 (12), pp.1383-1392. ⟨10.1016/j.jmoldx.2020.08.007⟩. ⟨hal-02958864⟩

Julie Dardare, Andréa Witz, Jean-Louis Merlin, Pauline Gilson, Alexandre Harlé. SMAD4 and the TGFβ pathway in patients with pancreatic ductal adenocarcinoma. International Journal of Molecular Sciences, MDPI, 2020, 21 (10), pp.3534. ⟨10.3390/ijms21103534⟩. ⟨hal-02617115⟩

Pauline Gilson, Julien Levy, Marie Rouyer, Jessica Demange, Marie Husson, et al.. Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancers. Scientific Reports, Nature Publishing Group, 2020, 10, pp.16386. ⟨10.1038/s41598-020-73421-5⟩. ⟨hal-02957897⟩

Kevin Litchfield, Stacey Stanislaw, Lisa Gallegos, Andrew Rowan, Desiree Schnidrig, et al.. Representative sequencing: Unbiased sampling of solid tumor tissue. Cell Reports, Elsevier Inc, 2020, 31 (5), pp.107550. ⟨10.1016/j.celrep.2020.107550⟩. ⟨hal-02565183⟩

Claire Franczak, Andréa Witz, Karen Geoffroy, Jessica Demange, Marie Rouyer, et al.. Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer. PLoS ONE, Public Library of Science, 2020, 15 (1), pp.e0227294. ⟨10.1371/journal.pone.0227294⟩. ⟨hal-02961025⟩

Claire Franczak, Ludovic Dubouis, Pauline Gilson, Marie Husson, Marie Rouyer, et al.. Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma. PLoS ONE, Public Library of Science, 2019, 14 (2), pp.e0212801. ⟨10.1371/journal.pone.0212801⟩. ⟨hal-02053754⟩

Stéphane Busca, Julia Salleron, Romain Boidot, Jean-Louis Merlin, Alexandre Harlé. Somatic substitution signature as an innovative tool in lung cancer diagnosis. Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.14561. ⟨10.1038/s41598-019-51155-3⟩. ⟨hal-02325054⟩

Claire Franczak, Shaun Kandathil, Pauline Gilson, Marie Husson, Marie Rouyer, et al.. Uncommon mutational profiles of metastatic colorectal cancer detected during routine genotyping using next generation sequencing. Scientific Reports, Nature Publishing Group, 2019, 9, pp.7083. ⟨10.1038/s41598-019-43646-0⟩. ⟨hal-02125314⟩

Vincent Massard, Alexandre Harlé, Lionel Uwer, Jean-Louis Merlin. Mutations du gène ESR1 : du fondamental à la clinique. Oncologie, Springer Verlag, 2019, 21 (1-4), pp.29-32. ⟨10.3166/onco-2019-0027⟩. ⟨hal-02325099⟩

Charlène Thiébaut, Amand Chesnel, Jean-Louis Merlin, Maelle Chesnel, Agnès Leroux, et al.. Dual epigenetic regulation of ERα36 expression in breast cancer cells. International Journal of Molecular Sciences, MDPI, 2019, 20 (11), pp.2637. ⟨10.3390/ijms20112637⟩. ⟨hal-02145413⟩

Pauline Gilson, Guillaume Drouot, Andréa Witz, Jean-Louis Merlin, Philippe Becuwe, et al.. Emerging roles of DDB2 in cancer. International Journal of Molecular Sciences, MDPI, 2019, 20 (20), pp.5168. ⟨10.3390/ijms20205168⟩. ⟨hal-02325073⟩

Aurélien Lambert, Julia Salleron, Maëva Lion, Marie Rouyer, Nicolas Lozano, et al.. Comparison of three real-time PCR assays for the detection of PIK3CA somatic mutations in formalin-fixed paraffin embedded tissues of patients with breast carcinomas. Pathology and Oncology Research, Springer Verlag, 2019, 25 (3), pp.1117-1123. ⟨10.1007/s12253-018-0538-x⟩. ⟨hal-01930792⟩

Pauline Gilson, Claire Franczak, Ludovic Dubouis, Marie Husson, Marie Rouyer, et al.. Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation. PLoS ONE, Public Library of Science, 2019, 14 (7), pp.e0219204. ⟨10.1371/journal.pone.0219204⟩. ⟨hal-02171684⟩

Claire Franczak, Pierre Filhine-Tresarrieu, Pauline Gilson, Jean-Louis Merlin, Lewis Au, et al.. Technical considerations for circulating tumor DNA detection in oncology. Expert Review of Molecular Diagnostics, Expert Reviews (formerly Future Drugs), 2019, 19 (2), pp.121-135. ⟨10.1080/14737159.2019.1568873⟩. ⟨hal-01987550⟩

Alexandre Harlé, Julie Guillet, Jacques Thomas, Jessica Demange, Gilles Dolivet, et al.. HPV insertional pattern as a personalized tumor marker for the optimized tumor diagnosis and follow-up of patients with HPV-associated carcinomas: a case report. BMC Cancer, BioMed Central, 2019, 19, pp.277. ⟨10.1186/s12885-019-5447-1⟩. ⟨hal-02086012⟩

Emmanuelle Jeannot, Alexandre Harlé, Allyson M. Holmes, Xavier Sastre-Garau. Nuclear factor I X is a recurrent target for HPV16 insertions in anal carcinomas. Genes, Chromosomes and Cancer, Wiley, 2018, 57 (12), pp.638-644. ⟨10.1002/gcc.22675⟩. ⟨hal-01930850⟩

Alexandre Harlé, Julie Guillet, Jacques Thomas, Xavier Sastre-Garau, Marie Rouyer, et al.. Evaluation and validation of HPV real-time PCR assay for the detection of HPV DNA in oral cytobrush and FFPE samples. Scientific Reports, Nature Publishing Group, 2018, 8, pp.11313. ⟨10.1038/s41598-018-29790-z⟩. ⟨hal-01930854⟩

Claire Franczak, Pierre Filhine-Tressarieu, Julien Broséus, Pauline Gilson, Jean-Louis Merlin, et al.. Clinical interests of circulating tumor DNA in oncology. Archives of Medical Research, Elsevier, 2018, 49 (5), pp.297-305. ⟨10.1016/j.arcmed.2018.10.007⟩. ⟨hal-01930849⟩

Marie-Anne Loriot, Joseph Ciccolini, Fabienne Thomas, Chantal Barin-Le-Guellec, Bernard Royer, et al.. Dépistage du déficit en dihydropyrimidine déshydrogénase (DPD) et sécurisation des chimiothérapies à base de fluoropyrimidines : mise au point et recommandations nationales du GPCO-Unicancer et du RNPGx. Bulletin du Cancer, John Libbey Eurotext, 2018, 105 (4), pp.397-407. ⟨10.1016/j.bulcan.2018.02.001⟩. ⟨hal-01930855⟩

Delphine Serre, Julia Salleron, Marie Husson, Agnès Leroux, Pauline Gilson, et al.. Accelerated BRAF mutation analysis using a fully automated PCR platform improves the management of patients with metastatic melanoma. Oncotarget, Impact journals, 2018, 9 (63), pp.32232-32237. ⟨10.18632/oncotarget.25957⟩. ⟨hal-03249247⟩

Guillaume Vogin, Jean-Louis Merlin, Alexandra Rousseau, Didier Peiffert, Alexandre Harlé, et al.. Absence of correlation between radiation-induced CD8 T-lymphocyte apoptosis and sequelae in patients with prostate cancer accidentally overexposed to radiation. Oncotarget, Impact journals, 2018, 9 (66), pp.32680-32689. ⟨10.18632/oncotarget.26001⟩. ⟨hal-01930852⟩

Alexandre Harlé, Claire Franczak. Authors’ Reply to Uguen: “Comparison of five different assays for the detection of BRAF mutations in formalin-fixed paraffin embedded tissues of patients with metastatic melanoma”. Molecular Diagnosis and Therapy, Adis, 2017, 21 (6), pp.695-696. ⟨10.1007/s40291-017-0301-0⟩. ⟨hal-01930856⟩

Claire Franczak, Julia Salleron, Cindy Dubois, Pierre Filhine-Tresarrieu, Agnès Leroux, et al.. Comparison of five different assays for the detection of BRAF mutations in formalin-fixed paraffin embedded tissues of patients with metastatic melanoma. Molecular Diagnosis and Therapy, Adis, 2017, 21 (2), pp.209-216. ⟨10.1007/s40291-017-0258-z⟩. ⟨hal-01664623⟩

Maëva Lion, Alexandre Harlé, Julia Salleron, Carole Ramacci, Mario Campone, et al.. Trastuzumab as a preoperative monotherapy does not inhibit HER2 downstream signaling in HER2-positive breast cancer. Oncology Letters, Spandidos Publications, 2016, 12 (3), pp.2028-2032. ⟨10.3892/ol.2016.4891⟩. ⟨hal-01418865⟩

Shuhui Chen, Elisa Cavazza, Catherine Barlier, Julia Salleron, Pierre Filhine-Tresarrieu, et al.. Beside P53 and PTEN: Identification of molecular alterations of the RAS/MAPK and PI3K/AKT signaling pathways in high-grade serous ovarian carcinomas to determine potential novel therapeutic targets. Oncology Letters, Spandidos Publications, 2016, 12 (5), pp.3264-3272. ⟨10.3892/ol.2016.5083⟩. ⟨hal-01418848⟩

Alexandre Harlé, Pierre Filhine-Tresarrieu, Marie Husson, Romain Boidot, Marie Rouyer, et al.. Rare RAS mutations in metastatic colorectal cancer detected during routine RAS genotyping using next generation sequencing. Targeted Oncology, Springer Verlag (Germany), 2016, 11 (3), pp.363-370. ⟨10.1007/s11523-015-0404-7⟩. ⟨hal-01241768⟩

Philippe Rauch, Jean-Louis Merlin, Lea Leufflen, Julia Salleron, Alexandre Harlé, et al.. Limited effectiveness of patent blue dye in addition to isotope scanning for identification of sentinel lymph nodes: Cross-sectional real-life study in 1024 breast cancer patients. International Journal of Surgery, Elsevier, 2016, 33, pp.177-181. ⟨10.1016/j.ijsu.2016.08.002⟩. ⟨hal-01418851⟩

Alexandre Harlé, Julia Salleron, Claire Franczak, Cindy Dubois, Pierre Filhine-Tresarrieu, et al.. Detection of BRAF mutations using a fully automated platform and comparison with high resolution melting, real-time allele specific amplification, immunohistochemistry and next generation sequencing assays, for patients with metastatic melanoma. PLoS ONE, Public Library of Science, 2016, 11 (4), pp.e0153576. ⟨10.1371/journal.pone.0153576⟩. ⟨hal-01320598⟩

Elise Pape, Delphine Michel, Julien Scala-Bertola, Thomas Schiestel, Alexandre Harlé, et al.. Effect of esomeprazole on the oral absorption of dasatinib in a patient with Philadelphia-positive acute lymphoblastic leukemia. British Journal of Clinical Pharmacology, Wiley, 2016, 81 (6), pp.1195-1196. ⟨10.1111/bcp.12895⟩. ⟨hal-01718101⟩

Alexandre Harlé, Julia Salleron, Géraldine Perkins, Camilla Pilati, Hélène Blons, et al.. Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers.. British Journal of Cancer, Cancer Research UK, 2015, 113 (4), pp.680-685. ⟨10.1038/bjc.2015.250⟩. ⟨hal-01241758⟩

Anne-Sophie Chretien, Alexandre Harlé, Magali Meyer-Lefebvre, Marie Rouyer, Marie Husson, et al.. Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer. Cancer Medicine, Wiley, 2013, 2 (1), pp.11-20. ⟨10.1002/cam4.47⟩. ⟨hal-00763929⟩

Alexandre Harlé, Benoît Busser, Marie Rouyer, Valentin Harter, Pascal Genin, et al.. Comparison of COBAS 4800 KRAS, TaqMan PCR and High Resolution Melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas. Virchows Archiv, Springer Verlag, 2013, 462 (3), pp.329-335. ⟨10.1007/s00428-013-1380-x⟩. ⟨hal-00733883⟩

Alexandre Harlé, Cindy Dubois, Marie Rouyer, Jean-Louis Merlin. Validation de méthode selon la norme ISO 15189 et le SH GTA 04 : application à la détection des mutations KRAS par méthode TaqMan. Annales de Biologie Clinique, John Libbey Eurotext, 2013, 71 (5), pp.603-607. ⟨10.1684/abc.2013.0869⟩. ⟨hal-00974859⟩

Alexandre Harlé, Maëva Lion, Marie Husson, Cindy Dubois, Jean-Louis Merlin. Validation de méthode selon la norme ISO 15189 et le SH GTA 04 : application à l'extraction et au dosage quantitatif de l'ADN par méthode spectrophotométrique. Annales de Biologie Clinique, John Libbey Eurotext, 2013, 71 (5), pp.608-614. ⟨10.1684/abc.2013.0891⟩. ⟨hal-00974857⟩

Alexandre Harlé, Jean-Louis Merlin. Biomarqueurs prédictifs de réponse aux thérapies ciblées en oncologie. Annales de Biologie Clinique, John Libbey Eurotext, 2013, 71 (1), pp.89-97. ⟨10.1684/abc.2013.0906⟩. ⟨hal-00974848⟩

Jean-Louis Merlin, Alexandre Harlé, Maëva Lion, Carole Ramacci, Agnès Leroux. Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins.. Oncology Reports, Spandidos Publications, 2013, 30 (4), pp.1943-1948. ⟨10.3892/or.2013.2645⟩. ⟨hal-00866242⟩

Alexandre Harlé, Maeva Lion, Nicolas Lozano, Marie Husson, Valentin Harter, et al.. Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: Correlation with clinicopathological criteria. Oncology Reports, Spandidos Publications, 2013, 29 (3), pp.1043-1052. ⟨10.3892/or.2013.2229⟩. ⟨hal-00823892⟩

Alexandre Harlé, Maëva Lion, Nicolas Lozano, Jean-Louis Merlin. Signification clinique, diagnostique et intérêt théranostique des mutations du gène PIK3CA dans le cancer du sein. Bulletin du Cancer, John Libbey Eurotext, 2013, 100 (10), pp.947-954. ⟨10.1684/bdc.2013.1827⟩. ⟨hal-00974881⟩

Charlène Thiébaut, Chloé Morel, Alexandre Harlé, Amand Chesnel, Agnès Leroux, et al.. From ERα66 to ERα36: a new predictive marker for cancer progression and therapeutic response in breast tumors ?. Colloque Interrégional Grand-Est de Recherche Translationnelle en Oncologie ONCOTRANS, CGE, Feb 2017, Besançon, France. ⟨hal-01667636⟩

Alexandre Harlé, Delphine Serre, Julia Salleron, Marie Husson, Agnès Leroux, et al.. Abstract 2719: Accelerated BRAF mutation analysis using a fully automated PCR platform improves the management of patients with metastatic melanoma : MELFAST trial. AACR Annual Meeting 2017, Apr 2017, Washington, DC, United States. pp.2719-2719, ⟨10.1158/1538-7445.AM2017-2719⟩. ⟨hal-03029979⟩

Charlène Thiébaut, Clémence Chamard-Jovenin, Amand Chesnel, Chloé Morel, Isabelle Grillier-Vuissoz, et al.. ERα36 expression: a key breast cancer risk factor?. 2nd EACR-OECI Conference Making it Personal - Cancer Precision Medicine, Mar 2017, Amsterdam, Netherlands. ⟨hal-01665545⟩

Charlène Thiébault, Chloé Morel, Alexandre Harlé, Amand Chesnel, Clémence Chamard-Jovenin, et al.. L’expression d’ER$\alpha$36: un nouveau marqueur de transformation néoplasique et de progression tumorale mammaire ?. 18e Journée Scientifique de la Ligue contre le cancer, Nov 2017, Illkirch, France. ⟨hal-02994508⟩

Charlène Thiébaut, Chloé Morel, Alexandre Harlé, Amand Chesnel, Agnès Leroux, et al.. From ERα66 to ERα36: a new predictive marker for cancer progression and therapeutic response in breast tumors ?. 10e Forum du Cancéropôle du Grand-Est, Nov 2016, Nancy, France. ⟨hal-01416426⟩

Charlène Thiébaut, Chloé Morel, Alexandre Harlé, Amand Chesnel, Agnès Leroux, et al.. From ERα66 to ERα36: a new predictive marker for cancer progression and therapeutic response in breast tumors ?. 21st World Congress on Advances in Oncology and 19th International Symposium on Molecular Medicine, Oct 2016, Athens, Greece. ⟨hal-01416456⟩

Shuhui Chen, Elisa Cavazza, Catherine Barlier, Pierre Filhine-Tresarrieu, Céline Gavoille, et al.. Identification of druggable targets in high-grade epithelial ovarian cancer (EOC) using next generation sequencing (NGS)–based molecular diagnostic.. ASCO 2016 annual meeting, Jun 2016, Chicago, IL, United States. pp.abstr e17076. ⟨hal-01320591⟩

Chloé Morel, Alexandre Harlé, Amand Chesnel, Clémence Chamard-Jovenin, Alain Jung, et al.. From ERalpha66 to ERalpha36 : a new predcitive marker for cancer progression and therapeutic response in breast tumors . 9e Forum du Cancéropôle du Grand Est, Nov 2015, Strasbourg, France. ⟨hal-01241778⟩

Jean-Louis Merlin, Marie Husson, Marie Rouyer, Agnès Leroux, Alexandre Harlé. Detection of rare somatic mutational profiles in metastatic colorectal cancer (mCRC) during routine RAS sequencing using next generation sequencing (NGS). ASCO 2015 annual meeting, May 2015, Chicago, IL, United States. pp.abstr 11055. ⟨hal-01241769⟩

Shuhui Chen, Elisa Cavazza, Catherine Barlier, Pierre Filhine-Tresarrieu, Céline Gavoille, et al.. Investigation of druggable molecular targets in high grade ovarian tumors using next generation sequencing (NGS). 9e Forum du Cancéropôle du Grand Est, Nov 2015, Strasbourg, France. ⟨hal-01241780⟩

Alexandre Harlé, Marie Husson, Marie Rouyer, Agnès Leroux, Jean-Louis Merlin. Detection of rare somatic mutational profiles in metastatic colorectal cancer (mCRC) during routine RAS next generation sequencing (NGS). 4ème Colloque Inter-Régional Grand-Est de Recherche Translationnelle en Oncologie, Oncotrans 2015, Jun 2015, Dijon, France. ⟨hal-01241773⟩

Alexandre Harlé, Romain Boidot, Marie Rouyer, Sandy Chevrier, Vincent Massard, et al.. Detection of KRAS, NRAS and BRAF somatic mutations in circulating tumor DNA using two assays of Next Generation Sequencing (NGS) for patients with metastatic colorectal cancer. 4ème Colloque Inter-Régional Grand-Est de Recherche Translationnelle en Oncologie, Oncotrans 2015, Jun 2015, Dijon, France. ⟨hal-01241774⟩

Alexandre Harlé, Marie Husson, Marie Rouyer, Agnès Leroux, Jean-Louis Merlin. Testing of KRAS, NRAS, BRAF and PIK3CA somatic mutations on FFPE tumors samples using bidirectionnal ultra-deep pyrosequencing. American Association for Cancer Research Annual meeting, AACR 2014, Apr 2014, San Diego (CA), United States. ⟨hal-01099669⟩

Jean-Louis Merlin, Alexandre Harlé, Anne-Sophie Chrétien, Carole Rammacci, Agnès Leroux. Activation of P38MAP kinase in estrogen-positive invasive breast cancers: Relation with HER2 and downstream signaling phosphorylated proteins expression. 2013 ASCO Annual Meeting, May 2013, Chicago, Il, United States. pp.CDROM. ⟨hal-00831927⟩

Alexandre Harlé, Maeva Lion, Nicolas Lozano, Marie Husson, Valentin Harter, et al.. PIK3CA exon 9 and 20 mutations analysis in breast cancers using PCR-HRM and PCR-ARMS: relations with clinicopathologic criteria. 14e Journées du Groupe de Pharmacologie Clinique Oncologique, Nov 2012, Paris, France. ⟨hal-00747745⟩

Alexandre Harlé, Jean-Louis Merlin. Comparaison des techniques COBAS KRAS 4800 et PCR TaqMan pour la détection des mutations somatiques du gène KRAS - Application dans le processus d'accréditation des laboratoires de biologie médicale selon la norme ISO 15189. 14e Journées du Groupe de Pharmacologie Clinique Oncologique, Nov 2012, Paris, France. ⟨hal-00747747⟩

Alexandre Harlé, Nicolas Lozano, Cyrielle Nicolaizeau, Maeva Lion, Marie Husson, et al.. Highly sensitive determination of PIK3CA exon 9 and 20 hotspot mutations in breast tumors. Annual Meeting of the American Society of Clinical Oncology, ASCO'2012, Jun 2012, Chicago, Illinois, United States. pp.CDROM. ⟨hal-00747400⟩

Alexandre Harlé, Jean-Louis Merlin. Comparison of COBAS 4800 KRAS, PCR TaqMan, and PCR high-resolution melting assays for the detection of KRAS somatic mutations in formalin-fixed paraffin-embedded colorectal tumors. Annual Meeting of the American Society of Clinical Oncology, ASCO'2012, Jun 2012, Chicago, Illinois, United States. pp.CDROM. ⟨hal-00747449⟩

Anne-Sophie Chrétien, Alexandre Harlé, Magali Meyer-Lefebvre, Marie Rouyer, Marie Husson, et al.. Optimization of routine KRAS mutation testing procedure for rational individualized first line targeted therapy selection in metastatic colorectal cancer. 2ème Colloque Inter-régional Grand-Est de Recherche Translationnelle en Oncologie, ONCOTRANS 2011, Sep 2011, Nancy, France. ⟨hal-00747885⟩

Alexandre Harlé, Julien Scala-Bertola, Nicolas Gambier, Jean-Yves Jouzeau, Pierre Gillet, et al.. Development of a simple method for the simultaneous determination of imatinib, norimatinib, dasatinib and nilotinib in human plasma by hplc photodiode array detector.. 2ème Colloque Inter-régional Grand-Est de Recherche Translationnelle en Oncologie, ONCOTRANS 2011, Sep 2011, Nancy, France. ⟨hal-00747903⟩

Anne-Sophie Chrétien, Alexandre Harlé, Magali Meyer-Lefebvre, Marie Rouyer, Marie Husson, et al.. Analyse des mutations KRAS dans les cancers colorectaux métastatiques : Optimisation des techniques et des délais pour la sélection rationnelle d'une première ligne thérapeutique. Carrefour Pathologie 2011, Nov 2011, Paris, France. pp.CDROM, ⟨10.1016/j.annpat.2011.09.039⟩. ⟨hal-00747865⟩

Alexandre Harlé. Cell-free DNA in the management of colorectal cancer. Florence Schaffner, Jean-Louis Merlin et Nikolas von Bubnoff. Tumor Liquid Biopsies, 215, Springer, pp.253-261, 2020, Recent Results in Cancer Research, 978-3-030-26438-3. ⟨10.1007/978-3-030-26439-0_13⟩. ⟨hal-02325084⟩

Alexandre Harlé. Marqueurs de réponse aux thérapies ciblées et personnalisation thérapeutique dans les cancers colorectaux métastatiques. Médecine humaine et pathologie. Université de Lorraine, 2014. Français. ⟨NNT : 2014LORR0267⟩. ⟨tel-01751299⟩

Alexandre Harlé. Marqueurs de réponse aux thérapies ciblées et personnalisation thérapeutique dans les cancers colorectaux métastatiques. Cancer. Université de Lorraine, 2014. Français. ⟨tel-01100524⟩

Alexandre Harlé. Recherche de biomarqueurs en cancérologie : Recherche préclinique sur le rôle de la protéine DDB2 dans les cancers du pancréas, recherche translationnelle et clinique sur le déploiement des analyses de l’ADN tumoral circulant. Cancer. Université de Lorraine, 2021. ⟨tel-03111110⟩