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Alexandre Harlé

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Publications

Validation of the Idylla GeneFusion assay to detect fusions and MET exon-skipping in non-small cell lung cancers

Pauline Gilson , Celso Pouget , Richard Belmonte , Smahane Fadil , Jessica Demange
Scientific Reports, 2023, 13 (1), pp.12909. ⟨10.1038/s41598-023-39749-4⟩
Article dans une revue hal-04301700v1

Personalized follow-up of circulating DNA in resected stage III/IV melanoma: PERCIMEL multicentric prospective study protocol

Lionnel Geoffrois , Alexandre Harlé , Nassim Sahki , Aleksandra Sikanja , Florence Granel-Brocard
BMC Cancer, 2023, 23 (1), pp.554. ⟨10.1186/s12885-023-11029-4⟩
Article dans une revue hal-04301664v1

Prediction of adjuvant gemcitabine sensitivity in resectable pancreatic adenocarcinoma using the GemPred RNA signature: An ancillary study of the PRODIGE-24/CCTG PA6 clinical trial

Rémy Nicolle , Jean-Baptiste Bachet , Alexandre Harlé , Juan Iovanna , Pascal Hammel
Journal of Clinical Oncology, 2023, 13 (1), pp.18741. ⟨10.1200/JCO.22.02668⟩
Article dans une revue hal-04301719v1
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ESR1 gene mutations and liquid biopsy in ER-positive breast cancers: A small step forward, a giant leap for personalization of endocrine therapy?

Margaux Betz , Vincent Massard , Pauline Gilson , Andréa Witz , Julie Dardare
Cancers, 2023, 15 (21), pp.5169. ⟨10.3390/cancers15215169⟩
Article dans une revue hal-04295094v1

CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines

Andréa Witz , Julie Dardare , Aurélie Francois , Marie Husson , Marie Rouyer
Scientific Reports, 2023, 13 (1), pp.18741. ⟨10.1038/s41598-023-45964-w⟩
Article dans une revue hal-04295078v1
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Deciphering tumour heterogeneity: From tissue to liquid biopsy

Pauline Gilson , Jean-Louis Merlin , Alexandre Harlé
Cancers, 2022, 14 (6), pp.1384. ⟨10.3390/cancers14061384⟩
Article dans une revue hal-03893328v1

Place de l’ADN tumoral circulant dans la prise en charge des cancers : entre défis et nouvelles perspectives

Paul Toussaint , Julie Dardare , Alexandre Harlé , Aurélien Lambert , Julien Levy
Innovations & Thérapeutiques en Oncologie, 2022, 8 (3), pp.147-156. ⟨10.1684/ito.2022.0318⟩
Article dans une revue hal-03901656v1
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Development of a clinical-biological model to assess tumor progression in metastatic pancreatic cancer: Post hoc analysis of the PRODIGE4/ACCORD11 trial

Julie Egea , Julia Salleron , Sophie Gourgou , Ahmet Ayav , Valérie Laurent
Cancers, 2022, 14 (20), pp.5068. ⟨10.3390/cancers14205068⟩
Article dans une revue hal-03901662v1

Intraoperative prediction of non‑sentinel lymph node metastases in breast cancer using cytokeratin 19 mRNA copy number: A retrospective analysis

Heloïse Pina , Julia Salleron , Pauline Gilson , Marie Husson , Marie Rouyer
Molecular and Clinical Oncology, 2022, 16 (3), pp.58. ⟨10.3892/mco.2022.2491⟩
Article dans une revue hal-03538820v1

DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy

Julie Dardare , Andréa Witz , Margaux Betz , Aurélie Francois , Morgane Meras
Frontiers in Oncology, 2022, 12, pp.1052163. ⟨10.3389/fonc.2022.1052163⟩
Article dans une revue hal-03901664v1
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Detection of microsatellite instability: State of the art and future applications in circulating tumour DNA (ctDNA)

Pauline Gilson , Jean-Louis Merlin , Alexandre Harlé
Cancers, 2021, 13 (7), pp.1491. ⟨10.3390/cancers13071491⟩
Article dans une revue hal-03408458v1

A NGS-based blood test for the diagnosis of invasive HPV-associated carcinomas with extensive viral genomic characterization

Xavier Sastre-Garau , Mamadou Diop , Fernando Martin , Gilles Dolivet , Frédéric Marchal
Clinical Cancer Research, 2021, 27 (19), pp.5307-5316. ⟨10.1158/1078-0432.CCR-21-0293⟩
Article dans une revue hal-03408468v1
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Standardisation of pathogenicity classification for somatic alterations in solid tumours and haematologic malignancies

Florence Koeppel , Etienne Muller , Alexandre Harlé , Celine Guien , Pierre Sujobert
European Journal of Cancer, 2021, 159, pp.1-15. ⟨10.1016/j.ejca.2021.08.047⟩
Article dans une revue hal-03408473v1

Evaluation of the Idylla ctEGFR mutation assay to detect EGFR mutations in plasma from patients with non-small cell lung cancers

Alexandre Harlé , Pauline Gilson , Chloé Saurel , Julia Salleron , Marie Husson
Scientific Reports, 2021, 11, pp.10470. ⟨10.1038/s41598-021-90091-z⟩
Article dans une revue hal-03408465v1
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Epithelial to mesenchymal transition in patients with pancreatic ductal adenocarcinoma: State-of-the-art and therapeutic opportunities

Julie Dardare , Andréa Witz , Jean-Louis Merlin , Agathe Bochnakian , Paul Toussaint
Pharmaceuticals, 2021, 14 (8), pp.740. ⟨10.3390/ph14080740⟩
Article dans une revue hal-03408471v1

Pathology of HPV-associated head and neck carcinomas: Recent data and perspectives for the development of specific tumor markers

Xavier Sastre-Garau , Alexandre Harlé
Frontiers in Oncology, 2020, 10, pp.528957. ⟨10.3389/fonc.2020.528957⟩
Article dans une revue hal-03079066v1
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SMAD4 and the TGFβ pathway in patients with pancreatic ductal adenocarcinoma

Julie Dardare , Andréa Witz , Jean-Louis Merlin , Pauline Gilson , Alexandre Harlé
International Journal of Molecular Sciences, 2020, 21 (10), pp.3534. ⟨10.3390/ijms21103534⟩
Article dans une revue hal-02617115v1

Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancers

Pauline Gilson , Julien Levy , Marie Rouyer , Jessica Demange , Marie Husson
Scientific Reports, 2020, 10, pp.16386. ⟨10.1038/s41598-020-73421-5⟩
Article dans une revue hal-02957897v1
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Comparison of pathogenicity prediction tools on somatic variants

Voreak Suybeng , Florence Koeppel , Alexandre Harlé , Etienne Rouleau
Journal of Molecular Diagnostics, 2020, 22 (12), pp.1383-1392. ⟨10.1016/j.jmoldx.2020.08.007⟩
Article dans une revue hal-02958864v1

Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer

Claire Franczak , Andréa Witz , Karen Geoffroy , Jessica Demange , Marie Rouyer
PLoS ONE, 2020, 15 (1), pp.e0227294. ⟨10.1371/journal.pone.0227294⟩
Article dans une revue hal-02961025v1

Representative sequencing: Unbiased sampling of solid tumor tissue

Kevin Litchfield , Stacey Stanislaw , Lisa Gallegos , Andrew Rowan , Desiree Schnidrig
Cell Reports, 2020, 31 (5), pp.107550. ⟨10.1016/j.celrep.2020.107550⟩
Article dans une revue hal-02565183v1

Identification of specific tumor markers in vulvar carcinoma through extensive human papillomavirus DNA characterization using next generation sequencing method

Jacques Thomas , Léa Leufflen , Virginie Chesnais , Ségolène Diry , Jessica Demange
Journal of Lower Genital Tract Disease, 2020, 24 (1), pp.53-60. ⟨10.1097/LGT.0000000000000498⟩
Article dans une revue hal-02425858v1

Uncommon mutational profiles of metastatic colorectal cancer detected during routine genotyping using next generation sequencing

Claire Franczak , Shaun Kandathil , Pauline Gilson , Marie Husson , Marie Rouyer
Scientific Reports, 2019, 9, pp.7083. ⟨10.1038/s41598-019-43646-0⟩
Article dans une revue hal-02125314v1

Mutations du gène ESR1 : du fondamental à la clinique

Vincent Massard , Alexandre Harlé , Lionel Uwer , Jean-Louis Merlin
Oncologie, 2019, 21 (1-4), pp.29-32. ⟨10.3166/onco-2019-0027⟩
Article dans une revue hal-02325099v1

Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation

Pauline Gilson , Claire Franczak , Ludovic Dubouis , Marie Husson , Marie Rouyer
PLoS ONE, 2019, 14 (7), pp.e0219204. ⟨10.1371/journal.pone.0219204⟩
Article dans une revue hal-02171684v1

Comparison of three real-time PCR assays for the detection of PIK3CA somatic mutations in formalin-fixed paraffin embedded tissues of patients with breast carcinomas

Aurélien Lambert , Julia Salleron , Maëva Lion , Marie Rouyer , Nicolas Lozano
Pathology and Oncology Research, 2019, 25 (3), pp.1117-1123. ⟨10.1007/s12253-018-0538-x⟩
Article dans une revue hal-01930792v1
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Dual epigenetic regulation of ERα36 expression in breast cancer cells

Charlène Thiébaut , Amand Chesnel , Jean-Louis Merlin , Maelle Chesnel , Agnès Leroux
International Journal of Molecular Sciences, 2019, 20 (11), pp.2637. ⟨10.3390/ijms20112637⟩
Article dans une revue hal-02145413v1

HPV insertional pattern as a personalized tumor marker for the optimized tumor diagnosis and follow-up of patients with HPV-associated carcinomas: a case report

Alexandre Harlé , Julie Guillet , Jacques Thomas , Jessica Demange , Gilles Dolivet
BMC Cancer, 2019, 19, pp.277. ⟨10.1186/s12885-019-5447-1⟩
Article dans une revue hal-02086012v1

Technical considerations for circulating tumor DNA detection in oncology

Claire Franczak , Pierre Filhine-Tresarrieu , Pauline Gilson , Jean-Louis Merlin , Lewis Au
Expert Review of Molecular Diagnostics, 2019, 19 (2), pp.121-135. ⟨10.1080/14737159.2019.1568873⟩
Article dans une revue hal-01987550v1

Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma

Claire Franczak , Ludovic Dubouis , Pauline Gilson , Marie Husson , Marie Rouyer
PLoS ONE, 2019, 14 (2), pp.e0212801. ⟨10.1371/journal.pone.0212801⟩
Article dans une revue hal-02053754v1
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Emerging roles of DDB2 in cancer

Pauline Gilson , Guillaume Drouot , Andréa Witz , Jean-Louis Merlin , Philippe Becuwe
International Journal of Molecular Sciences, 2019, 20 (20), pp.5168. ⟨10.3390/ijms20205168⟩
Article dans une revue hal-02325073v1

Somatic substitution signature as an innovative tool in lung cancer diagnosis

Stéphane Busca , Julia Salleron , Romain Boidot , Jean-Louis Merlin , Alexandre Harlé
Scientific Reports, 2019, 9 (1), pp.14561. ⟨10.1038/s41598-019-51155-3⟩
Article dans une revue hal-02325054v1

Dépistage du déficit en dihydropyrimidine déshydrogénase (DPD) et sécurisation des chimiothérapies à base de fluoropyrimidines : mise au point et recommandations nationales du GPCO-Unicancer et du RNPGx

Marie-Anne Loriot , Joseph Ciccolini , Fabienne Thomas , Chantal Barin-Le-Guellec , Bernard Royer
Bulletin du Cancer, 2018, 105 (4), pp.397-407. ⟨10.1016/j.bulcan.2018.02.001⟩
Article dans une revue hal-01930855v1

Accelerated BRAF mutation analysis using a fully automated PCR platform improves the management of patients with metastatic melanoma

Delphine Serre , Julia Salleron , Marie Husson , Agnès Leroux , Pauline Gilson
Oncotarget, 2018, 9 (63), pp.32232-32237. ⟨10.18632/oncotarget.25957⟩
Article dans une revue hal-03249247v1

Evaluation and validation of HPV real-time PCR assay for the detection of HPV DNA in oral cytobrush and FFPE samples

Alexandre Harlé , Julie Guillet , Jacques Thomas , Xavier Sastre-Garau , Marie Rouyer
Scientific Reports, 2018, 8, pp.11313. ⟨10.1038/s41598-018-29790-z⟩
Article dans une revue hal-01930854v1

Nuclear factor I X is a recurrent target for HPV16 insertions in anal carcinomas

Emmanuelle Jeannot , Alexandre Harlé , Allyson M. Holmes , Xavier Sastre-Garau
Genes, Chromosomes & Cancer, 2018, 57 (12), pp.638-644. ⟨10.1002/gcc.22675⟩
Article dans une revue hal-01930850v1

Absence of correlation between radiation-induced CD8 T-lymphocyte apoptosis and sequelae in patients with prostate cancer accidentally overexposed to radiation

Guillaume Vogin , Jean-Louis Merlin , Alexandra Rousseau , Didier Peiffert , Alexandre Harlé
Oncotarget, 2018, 9 (66), pp.32680-32689. ⟨10.18632/oncotarget.26001⟩
Article dans une revue hal-01930852v1

Clinical interests of circulating tumor DNA in oncology

Claire Franczak , Pierre Filhine-Tressarieu , Julien Broséus , Pauline Gilson , Jean-Louis Merlin
Archives of Medical Research, 2018, 49 (5), pp.297-305. ⟨10.1016/j.arcmed.2018.10.007⟩
Article dans une revue hal-01930849v1

Authors’ Reply to Uguen: “Comparison of five different assays for the detection of BRAF mutations in formalin-fixed paraffin embedded tissues of patients with metastatic melanoma”

Alexandre Harlé , Claire Franczak
Molecular Diagnosis and Therapy, 2017, 21 (6), pp.695-696. ⟨10.1007/s40291-017-0301-0⟩
Article dans une revue hal-01930856v1

Comparison of five different assays for the detection of BRAF mutations in formalin-fixed paraffin embedded tissues of patients with metastatic melanoma

Claire Franczak , Julia Salleron , Cindy Dubois , Pierre Filhine-Tresarrieu , Agnès Leroux
Molecular Diagnosis and Therapy, 2017, 21 (2), pp.209-216. ⟨10.1007/s40291-017-0258-z⟩
Article dans une revue hal-01664623v1

Limited effectiveness of patent blue dye in addition to isotope scanning for identification of sentinel lymph nodes: Cross-sectional real-life study in 1024 breast cancer patients

Philippe Rauch , Jean-Louis Merlin , Lea Leufflen , Julia Salleron , Alexandre Harlé
International Journal of Surgery, 2016, 33, pp.177-181. ⟨10.1016/j.ijsu.2016.08.002⟩
Article dans une revue hal-01418851v1

Detection of BRAF mutations using a fully automated platform and comparison with high resolution melting, real-time allele specific amplification, immunohistochemistry and next generation sequencing assays, for patients with metastatic melanoma

Alexandre Harlé , Julia Salleron , Claire Franczak , Cindy Dubois , Pierre Filhine-Tresarrieu
PLoS ONE, 2016, 11 (4), pp.e0153576. ⟨10.1371/journal.pone.0153576⟩
Article dans une revue hal-01320598v1

Rare RAS mutations in metastatic colorectal cancer detected during routine RAS genotyping using next generation sequencing

Alexandre Harlé , Pierre Filhine-Tresarrieu , Marie Husson , Romain Boidot , Marie Rouyer
Targeted Oncology, 2016, 11 (3), pp.363-370. ⟨10.1007/s11523-015-0404-7⟩
Article dans une revue hal-01241768v1

Beside P53 and PTEN: Identification of molecular alterations of the RAS/MAPK and PI3K/AKT signaling pathways in high-grade serous ovarian carcinomas to determine potential novel therapeutic targets

Shuhui Chen , Elisa Cavazza , Catherine Barlier , Julia Salleron , Pierre Filhine-Tresarrieu
Oncology Letters, 2016, 12 (5), pp.3264-3272. ⟨10.3892/ol.2016.5083⟩
Article dans une revue hal-01418848v1

Trastuzumab as a preoperative monotherapy does not inhibit HER2 downstream signaling in HER2-positive breast cancer

Maëva Lion , Alexandre Harlé , Julia Salleron , Carole Ramacci , Mario Campone
Oncology Letters, 2016, 12 (3), pp.2028-2032. ⟨10.3892/ol.2016.4891⟩
Article dans une revue hal-01418865v1
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Effect of esomeprazole on the oral absorption of dasatinib in a patient with Philadelphia-positive acute lymphoblastic leukemia

Elise Pape , Delphine Michel , Julien Scala-Bertola , Thomas Schiestel , Alexandre Harlé
British Journal of Clinical Pharmacology, 2016, 81 (6), pp.1195-1196. ⟨10.1111/bcp.12895⟩
Article dans une revue hal-01718101v1

Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers.

Alexandre Harlé , Julia Salleron , Géraldine Perkins , Camilla Pilati , Hélène Blons
British Journal of Cancer, 2015, 113 (4), pp.680-685. ⟨10.1038/bjc.2015.250⟩
Article dans une revue hal-01241758v1

Validation de méthode selon la norme ISO 15189 et le SH GTA 04 : application à l'extraction et au dosage quantitatif de l'ADN par méthode spectrophotométrique

Alexandre Harlé , Maëva Lion , Marie Husson , Cindy Dubois , Jean-Louis Merlin
Annales de Biologie Clinique, 2013, 71 (5), pp.608-614. ⟨10.1684/abc.2013.0891⟩
Article dans une revue hal-00974857v1

Validation de méthode selon la norme ISO 15189 et le SH GTA 04 : application à la détection des mutations KRAS par méthode TaqMan

Alexandre Harlé , Cindy Dubois , Marie Rouyer , Jean-Louis Merlin
Annales de Biologie Clinique, 2013, 71 (5), pp.603-607. ⟨10.1684/abc.2013.0869⟩
Article dans une revue hal-00974859v1

Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins.

Jean-Louis Merlin , Alexandre Harlé , Maëva Lion , Carole Ramacci , Agnès Leroux
Oncology Reports, 2013, 30 (4), pp.1943-1948. ⟨10.3892/or.2013.2645⟩
Article dans une revue hal-00866242v1

Biomarqueurs prédictifs de réponse aux thérapies ciblées en oncologie

Alexandre Harlé , Jean-Louis Merlin
Annales de Biologie Clinique, 2013, 71 (1), pp.89-97. ⟨10.1684/abc.2013.0906⟩
Article dans une revue hal-00974848v1

Signification clinique, diagnostique et intérêt théranostique des mutations du gène PIK3CA dans le cancer du sein

Alexandre Harlé , Maëva Lion , Nicolas Lozano , Jean-Louis Merlin
Bulletin du Cancer, 2013, 100 (10), pp.947-954. ⟨10.1684/bdc.2013.1827⟩
Article dans une revue hal-00974881v1

Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: Correlation with clinicopathological criteria

Alexandre Harlé , Maeva Lion , Nicolas Lozano , Marie Husson , Valentin Harter
Oncology Reports, 2013, 29 (3), pp.1043-1052. ⟨10.3892/or.2013.2229⟩
Article dans une revue hal-00823892v1

Comparison of COBAS 4800 KRAS, TaqMan PCR and High Resolution Melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas

Alexandre Harlé , Benoît Busser , Marie Rouyer , Valentin Harter , Pascal Genin
Virchows Archiv, 2013, 462 (3), pp.329-335. ⟨10.1007/s00428-013-1380-x⟩
Article dans une revue hal-00733883v1

Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer

Anne-Sophie Chretien , Alexandre Harlé , Magali Meyer-Lefebvre , Marie Rouyer , Marie Husson
Cancer Medicine, 2013, 2 (1), pp.11-20. ⟨10.1002/cam4.47⟩
Article dans une revue hal-00763929v1

CICLADES: Monitoring of ESR1, PIK3CA and AKT1 ctDNA mutations during real-life follow-up of patients with advanced breast cancer treated with endocrine therapy

Vincent Massard , Lionel Uwer , Julia Salleron , Mathilde Deblock , Anne Kieffer
San Antonio Breast Cancer Symposium, Dec 2018, San Antonio, TX, United States. pp.OT1-03-02-OT1-03-02, ⟨10.1158/1538-7445.SABCS18-OT1-03-02⟩
Communication dans un congrès hal-03030007v1

Abstract 2719: Accelerated BRAF mutation analysis using a fully automated PCR platform improves the management of patients with metastatic melanoma : MELFAST trial

Alexandre Harlé , Delphine Serre , Julia Salleron , Marie Husson , Agnès Leroux
AACR Annual Meeting 2017, Apr 2017, Washington, DC, United States. pp.2719-2719, ⟨10.1158/1538-7445.AM2017-2719⟩
Communication dans un congrès hal-03029979v1

ERα36 expression: a key breast cancer risk factor?

Charlène Thiébaut , Clémence Chamard-Jovenin , Amand Chesnel , Chloé Morel , Isabelle Grillier-Vuissoz
2nd EACR-OECI Conference Making it Personal - Cancer Precision Medicine, Mar 2017, Amsterdam, Netherlands
Communication dans un congrès hal-01665545v1

From ERα66 to ERα36: a new predictive marker for cancer progression and therapeutic response in breast tumors ?

Charlène Thiébaut , Chloé Morel , Alexandre Harlé , Amand Chesnel , Agnès Leroux
Colloque Interrégional Grand-Est de Recherche Translationnelle en Oncologie ONCOTRANS, CGE, Feb 2017, Besançon, France
Communication dans un congrès hal-01667636v1

L’expression d’ER$\alpha$36: un nouveau marqueur de transformation néoplasique et de progression tumorale mammaire ?

Charlène Thiébault , Chloé Morel , Alexandre Harlé , Amand Chesnel , Clémence Chamard-Jovenin
18e Journée Scientifique de la Ligue contre le cancer, Nov 2017, Illkirch, France
Communication dans un congrès hal-02994508v1

Identification of druggable targets in high-grade epithelial ovarian cancer (EOC) using next generation sequencing (NGS)–based molecular diagnostic.

Shuhui Chen , Elisa Cavazza , Catherine Barlier , Pierre Filhine-Tresarrieu , Céline Gavoille
ASCO 2016 annual meeting, Jun 2016, Chicago, IL, United States. pp.abstr e17076
Communication dans un congrès hal-01320591v1

From ERα66 to ERα36: a new predictive marker for cancer progression and therapeutic response in breast tumors ?

Charlène Thiébaut , Chloé Morel , Alexandre Harlé , Amand Chesnel , Agnès Leroux
21st World Congress on Advances in Oncology and 19th International Symposium on Molecular Medicine, Oct 2016, Athens, Greece
Communication dans un congrès hal-01416456v1

From ERα66 to ERα36: a new predictive marker for cancer progression and therapeutic response in breast tumors ?

Charlène Thiébaut , Chloé Morel , Alexandre Harlé , Amand Chesnel , Agnès Leroux
10e Forum du Cancéropôle du Grand-Est, Nov 2016, Nancy, France
Communication dans un congrès hal-01416426v1

Investigation of druggable molecular targets in high grade ovarian tumors using next generation sequencing (NGS)

Shuhui Chen , Elisa Cavazza , Catherine Barlier , Pierre Filhine-Tresarrieu , Céline Gavoille
9e Forum du Cancéropôle du Grand Est, Nov 2015, Strasbourg, France
Communication dans un congrès hal-01241780v1

Detection of rare somatic mutational profiles in metastatic colorectal cancer (mCRC) during routine RAS sequencing using next generation sequencing (NGS)

Jean-Louis Merlin , Marie Husson , Marie Rouyer , Agnès Leroux , Alexandre Harlé
ASCO 2015 annual meeting, May 2015, Chicago, IL, United States. pp.abstr 11055
Communication dans un congrès hal-01241769v1

From ERalpha66 to ERalpha36 : a new predcitive marker for cancer progression and therapeutic response in breast tumors

Chloé Morel , Alexandre Harlé , Amand Chesnel , Clémence Chamard-Jovenin , Alain Jung
9e Forum du Cancéropôle du Grand Est, Nov 2015, Strasbourg, France
Communication dans un congrès hal-01241778v1

Detection of rare somatic mutational profiles in metastatic colorectal cancer (mCRC) during routine RAS next generation sequencing (NGS)

Alexandre Harlé , Marie Husson , Marie Rouyer , Agnès Leroux , Jean-Louis Merlin
4ème Colloque Inter-Régional Grand-Est de Recherche Translationnelle en Oncologie, Oncotrans 2015, Jun 2015, Dijon, France
Communication dans un congrès hal-01241773v1

Detection of KRAS, NRAS and BRAF somatic mutations in circulating tumor DNA using two assays of Next Generation Sequencing (NGS) for patients with metastatic colorectal cancer

Alexandre Harlé , Romain Boidot , Marie Rouyer , Sandy Chevrier , Vincent Massard
4ème Colloque Inter-Régional Grand-Est de Recherche Translationnelle en Oncologie, Oncotrans 2015, Jun 2015, Dijon, France
Communication dans un congrès hal-01241774v1

Testing of KRAS, NRAS, BRAF and PIK3CA somatic mutations on FFPE tumors samples using bidirectionnal ultra-deep pyrosequencing

Alexandre Harlé , Marie Husson , Marie Rouyer , Agnès Leroux , Jean-Louis Merlin
American Association for Cancer Research Annual meeting, AACR 2014, Apr 2014, San Diego (CA), United States
Communication dans un congrès hal-01099669v1

Activation of P38MAP kinase in estrogen-positive invasive breast cancers: Relation with HER2 and downstream signaling phosphorylated proteins expression

Jean-Louis Merlin , Alexandre Harlé , Anne-Sophie Chrétien , Carole Rammacci , Agnès Leroux
2013 ASCO Annual Meeting, May 2013, Chicago, Il, United States. pp.CDROM
Communication dans un congrès hal-00831927v1

Highly sensitive determination of PIK3CA exon 9 and 20 hotspot mutations in breast tumors

Alexandre Harlé , Nicolas Lozano , Cyrielle Nicolaizeau , Maeva Lion , Marie Husson
Annual Meeting of the American Society of Clinical Oncology, ASCO'2012, Jun 2012, Chicago, Illinois, United States. pp.CDROM
Communication dans un congrès hal-00747400v1

Comparison of COBAS 4800 KRAS, PCR TaqMan, and PCR high-resolution melting assays for the detection of KRAS somatic mutations in formalin-fixed paraffin-embedded colorectal tumors

Alexandre Harlé , Jean-Louis Merlin
Annual Meeting of the American Society of Clinical Oncology, ASCO'2012, Jun 2012, Chicago, Illinois, United States. pp.CDROM
Communication dans un congrès hal-00747449v1

PIK3CA exon 9 and 20 mutations analysis in breast cancers using PCR-HRM and PCR-ARMS: relations with clinicopathologic criteria

Alexandre Harlé , Maeva Lion , Nicolas Lozano , Marie Husson , Valentin Harter
14e Journées du Groupe de Pharmacologie Clinique Oncologique, Nov 2012, Paris, France
Communication dans un congrès hal-00747745v1

Comparaison des techniques COBAS KRAS 4800 et PCR TaqMan pour la détection des mutations somatiques du gène KRAS - Application dans le processus d'accréditation des laboratoires de biologie médicale selon la norme ISO 15189

Alexandre Harlé , Jean-Louis Merlin
14e Journées du Groupe de Pharmacologie Clinique Oncologique, Nov 2012, Paris, France
Communication dans un congrès hal-00747747v1

Analyse des mutations KRAS dans les cancers colorectaux métastatiques : Optimisation des techniques et des délais pour la sélection rationnelle d'une première ligne thérapeutique

Anne-Sophie Chrétien , Alexandre Harlé , Magali Meyer-Lefebvre , Marie Rouyer , Marie Husson
Carrefour Pathologie 2011, Nov 2011, Paris, France. pp.CDROM, ⟨10.1016/j.annpat.2011.09.039⟩
Communication dans un congrès hal-00747865v1

Development of a simple method for the simultaneous determination of imatinib, norimatinib, dasatinib and nilotinib in human plasma by hplc photodiode array detector.

Alexandre Harlé , Julien Scala-Bertola , Nicolas Gambier , Jean-Yves Jouzeau , Pierre Gillet
2ème Colloque Inter-régional Grand-Est de Recherche Translationnelle en Oncologie, ONCOTRANS 2011, Sep 2011, Nancy, France
Communication dans un congrès hal-00747903v1

Optimization of routine KRAS mutation testing procedure for rational individualized first line targeted therapy selection in metastatic colorectal cancer

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2ème Colloque Inter-régional Grand-Est de Recherche Translationnelle en Oncologie, ONCOTRANS 2011, Sep 2011, Nancy, France
Communication dans un congrès hal-00747885v1

Cell-free DNA in the management of colorectal cancer

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Florence Schaffner, Jean-Louis Merlin et Nikolas von Bubnoff. Tumor Liquid Biopsies, 215, Springer, pp.253-261, 2020, Recent Results in Cancer Research, 978-3-030-26438-3. ⟨10.1007/978-3-030-26439-0_13⟩
Chapitre d'ouvrage hal-02325084v1