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Structural Basis for DNA Gyrase Interaction with Coumermycin A1

Arnaud Vanden Broeck , Alastair G Mcewen , Yassmine Chebaro , Noelle Potier , Valerie Lamour
Journal of Medicinal Chemistry, 2018, 62 (8), pp.4225-4231. ⟨10.1021/acs.jmedchem.8b01928⟩
Article dans une revue hal-02402192v1

Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification

Olga Kolaj-Robin , A Mcewen , Jean Cavarelli , Bertrand Séraphin
FEBS Journal, 2015, 282 (5), pp.819-833. ⟨10.1111/febs.13199⟩
Article dans une revue hal-02179589v1
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Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site

Elise Naudin , Alastair G. Mcewen , Sophia K. Tan , Pierre Poussin-Courmontagne , Jean Louis Schmitt , et al.
Journal of the American Chemical Society, 2021, 143 (9), pp.3330-3339. ⟨10.1021/jacs.0c10053⟩
Article dans une revue hal-03196564v1
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A structural signature motif enlightens the origin and diversification of nuclear receptors

Brice Beinsteiner , Gabriel V Markov , Stéphane Erb , Yassmine Chebaro , Alastair G Mcewen , et al.
PLoS Genetics, 2021, 17 (4), pp.e1009492. ⟨10.1371/journal.pgen.1009492⟩
Article dans une revue hal-03222330v1

Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor

Judit Osz , Alastair McEwen , Pierre Poussin-Courmontagne , Emmanuel Moutier , Catherine Birck , et al.
Scientific Reports, 2015, 5 (1), pp.8216. ⟨10.1038/srep08216⟩
Article dans une revue hal-03714548v1
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A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress

Eric Moeglin , Dominique Desplancq , Audrey Stoessel , Christian Massute , Jeremy Ranniger , et al.
Cancers, 2021, 13 (13), pp.3317. ⟨10.3390/cancers13133317⟩
Article dans une revue hal-03453976v1

The SOUL family of heme-binding proteins: Structure and function 15 years later

Brian J. Goodfellow , Filipe Freire , Ana Luisa Carvalho , Susana S. Aveiro , Peggy Charbonnier , et al.
Coordination Chemistry Reviews, 2021, 448, pp.214189. ⟨10.1016/j.ccr.2021.214189⟩
Article dans une revue hal-03364400v1

Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis

G Peng , A Mcewen , V Olieric , Céline Schmitt , Sébastien Albrecht , et al.
Proteins, 2017, 85 (8), pp.1413-1421. ⟨10.1002/prot.25301⟩
Article dans une revue hal-02161625v1
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FFAT motif phosphorylation controls formation and lipid transfer function of inter‐organelle contacts

Thomas Di Mattia , Arthur Martinet , Souade Ikhlef , Alastair G Mcewen , Yves Nominé , et al.
EMBO Journal, 2020, 39 (23), ⟨10.15252/embj.2019104369⟩
Article dans une revue hal-03045974v1

A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor retinoic X receptor alpha

Jérôme Eberhardt , Alastair Mcewen , W Bourguet , Dino Moras , Annick Dejaegere
Acta crystallographica Section F : Structural biology communications [2014-..], 2019, 75 (Pt 2), pp.98-104. ⟨10.1107/S2053230X18018022⟩
Article dans une revue hal-03676415v1

Crystal Structure of Staphopain C from Staphylococcus aureus

Malgorzata Magoch , Alastair McEwen , Valeria Napolitano , Benedykt Władyka , Grzegorz Dubin
Molecules, 2023, 28 (11), pp.4407. ⟨10.3390/molecules28114407⟩
Article dans une revue hal-04158826v1

The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers

Nada Lallous , Pierre Legrand , Alastair McEwen , Santiago Ramón-Maiques , Jean-Pierre Samama , et al.
PLoS ONE, 2011, 6 (11), pp.e27599. ⟨10.1371/journal.pone.0027599⟩
Article dans une revue hal-03714507v1
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Monitoring the Production of High Diffraction-Quality Crystals of Two Enzymes in Real Time Using In Situ Dynamic Light Scattering

Raphaël de Wijn , Kévin Rollet , Sylvain Engilberge , Alastair G Mcewen , Oliver Hennig , et al.
Crystals, 2020, 10 (2), pp.65. ⟨10.3390/cryst10020065⟩
Article dans une revue hal-02464277v1
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Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins

Katia Zanier , Sebastian Charbonnier , Abdellahi Ould M'Hamed Ould Sidi , Alastair G Mcewen , Maria Giovanna Ferrario , et al.
Science, 2013, 339 (6120), pp.694-698. ⟨10.1126/science.1229934⟩
Article dans une revue hal-03049110v1

On the Structure and Function of the Phytoene Desaturase CRTI from Pantoea ananatis, a Membrane-Peripheral and FAD-Dependent Oxidase/Isomerase

Patrick Schaub , Qiuju Yu , Sandra Gemmecker , Pierre Poussin-Courmontagne , Justine Mailliot , et al.
PLoS ONE, 2012, 7 (6), pp.e39550. ⟨10.1371/journal.pone.0039550⟩
Article dans une revue hal-03714517v1
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Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR–RXR

Judit Osz , Alastair G Mcewen , Maxime Bourguet , Frédéric Przybilla , Carole Peluso-Iltis , et al.
Nucleic Acids Research, 2020, 48 (17), pp.9969 - 9985. ⟨10.1093/nar/gkaa697⟩
Article dans une revue hal-03032811v1

Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins

Katia Zanier , Sebastian Charbonnier , Abdellahi Ould M'Hamed Ould Sidi , Alastair Mcewen , Maria Giovanna Ferrario , et al.
Science, 2013, 339 (6120), pp.694-698. ⟨10.1126/science.1229934⟩
Article dans une revue hal-03406375v1
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Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA

Abdul Kareem Mohideen Patel , Pierre Vilela , Tajith Baba Shaik , Alastair G Mcewen , Isabelle Hazemann , et al.
Nucleic Acids Research, 2023, 51 (16), pp.8864-8879. ⟨10.1093/nar/gkad632⟩
Article dans une revue hal-04234634v1
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A novel nuclear receptor subfamily enlightens the origin of heterodimerization

Brice Beinsteiner , Gabriel V Markov , Maxime Bourguet , Alastair G Mcewen , Stéphane Erb , et al.
BMC Biology, 2022, 20 (1), pp.217. ⟨10.1186/s12915-022-01413-0⟩
Article dans une revue hal-03843774v1

The crystal structure of the 5′ functional domain of the transcription riboregulator 7SK

Denise Martinez-Zapien , Pierre Legrand , Alastair McEwen , Florence Proux , Tristan Cragnolini , et al.
Nucleic Acids Research, 2017, pp.gkw1351. ⟨10.1093/nar/gkw1351⟩
Article dans une revue hal-03714539v1

Forced Evolution of a Herbicide Detoxifying Glutathione Transferase

David Dixon , Alastair McEwen , Adrian Lapthorn , Robert Edwards
Journal of Biological Chemistry, 2003, 278 (26), pp.23930-23935. ⟨10.1074/jbc.M303620200⟩
Article dans une revue hal-03714263v1
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Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP

Christopher Browning , Alastair Mcewen , Kotaro Mori , Taiyo Yokoi , Dino Moras , et al.
Journal of Pesticide Science, 2021, 46 (1), pp.88-100. ⟨10.1584/jpestics.D20-095⟩
Article dans une revue hal-03704464v1
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Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation

Emmanuel Salomon , Marjorie Schmitt , Elisabeth Mouray , Alastair G Mcewen , Lotfi Bounaadja , et al.
Bioorganic Chemistry, 2020, 98, pp.103750. ⟨10.1016/j.bioorg.2020.103750⟩
Article dans une revue hal-02530528v1

Modulation of RXR-DNA complex assembly by DNA context

Judit Osz , Alastair G Mcewen , Justine Wolf , Pierre Poussin-Courmontagne , Carole Peluso-Iltis , et al.
Molecular and Cellular Endocrinology, 2019, 481, pp.44-52. ⟨10.1016/j.mce.2018.11.008⟩
Article dans une revue hal-02383165v1
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TRAF4 Is a Novel Phosphoinositide-Binding Protein Modulating Tight Junctions and Favoring Cell Migration

Adrien Rousseau , Alastair G Mcewen , Pierre Poussin-Courmontagne , Didier Rognan , Yves Nominé , et al.
PLoS Biology, 2013, 11 (12), pp.e1001726. ⟨10.1371/journal.pbio.1001726⟩
Article dans une revue inserm-02131600v1