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Alain Bruhat -Directeur de Recherche INRAE


 

BRUHAT, Alain                               Directeur de Recherche à INRAE

 

Né le 29 mai 1964, à Montluçon (03)   Centre Auvergne-Rhône-Alpes - Site de Theix

 

Tel : +33 4 73 62 41 50                     UMR 1019 INRAE-Université Clermont Auvergne

 

alain.bruhat@inrae.fr                      Unité de Nutrition Humaine (UNH)

 

                                                   Equipe PROTEOSTASIS

 

Titres universitaires :

 

24 janvier 2002 : Habilitation à Diriger les Recherches, U. d’Auvergne, Clermont-Fd.

 

22 décembre 1992 : Doctorat de Biologie Cellulaire et Moléculaire, INSERM U384, U. Blaise Pascal, Clermont-Fd.

 

Activité de recherche :

 

Depuis 2011: Directeur de Recherche 2ème classe INRAE dans l’UMR 1019 INRA/UCA (A. Mazur) à Theix, équipe PROTEOSTASIS (P. Fafournoux). « Etude des mécanismes d’adaptation à un stress nutritionnel».

 

1997-2011 : Chargé de Recherche 1ère classe INRAE dans l’UMR 1019 INRA/Université Clermont I, (J.M Chardigny) à Theix, équipe Gènes-Nutriments (P. Fafournoux). «Etude des mécanismes d’adaptation à un stress nutritionnel».

 

1996-1997 : 2ème Post-doctorat dans l’UR238 INRA (M. Ferrara) à Theix, équipe « Gènes-Nutriments » (P. Fafournoux). «Etude de la régulation de l'expression des gènes par les acides aminés chez les mammifères».

 

1993-1995 : 1er Post-doctorat au Friedrich Miescher Institut à Bàle (Suisse), équipe de J.P. Jost. «Etude de la régulation par l’oestradiol de la fixation sur l’ADN méthylé d'une protéine répresseur du gène vitellogenine II de poulet».

 

1988-1992 : Doctorat (allocation MENRT) dans l’U384 INSERM (B. Dastugue) à Clermont-Fd, équipe de J.L. Couderc. «Etude de la régulation de la transcription du gène β3 tubuline par l'ecdysone dans une lignée de cellules de Drosophile en culture».

 

Activité d’enseignement :

 

Depuis 2008 : co-responsable de l’UE3 « Nutrition, Signalisation et Expression génique » du Master Biologie Santé de l’Université Clermont Auvergne. Cours dans ce module sur « Stress cellulaire, protéines HSP, stress du réticulum endoplasmique et développement de pathologies associées ». Membre du jury de soutenance de stage M2.

 

Animation et administration de la recherche :

 

Depuis 2017: Membre de l’European Society of Gene and Cell Therapy (ESGCT)

 

Depuis 2016: Membre élu du Conseil de Gestion du département INRA AlimH.

 

Depuis 2012: Membre du Club Francophone de l’Autophagie (SFTCG)

 

Depuis 2008: Co-animateur du groupe « Animation Scientifique » du CRNH Auvergne.

 

Activité d’encadrement :

 

6 encadrements ou co-encadrement de Thèse d’université

 

7 encadrements d’étudiants en M2

 

Valorisation-Brevets :

 

1 brevet national (2011) et 2 brevets internationaux (2013, 2016)

 

Publications (articles à comité de lecture):

 

67 publications internationales / h-index : 28

 


Journal articles59 documents

  • Eva Delbrel, Abdoulaye Soumare, Adnan Naguez, Rabab Label, Olivier Bernard, et al.. HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis. Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.17939. ⟨10.1038/s41598-018-36063-2⟩. ⟨hal-01974137⟩
  • Alain Bruhat, Cedric Chaveroux, Valerie Carraro, Celine Jousse, Julien Averous, et al.. Réguler l’expression d’un transgène thérapeutique par un régime alimentaire carencé en un acide aminé indispensable. Tuning transgene expression with an artificial diet: a compelling resource in gene therapy.. médecine/sciences, EDP Sciences, 2017, 33 (2), pp.136-139. ⟨10.1051/medsci/20173302007⟩. ⟨hal-01595228⟩
  • Morgane Louessard, Isabelle Bardou, Eloïse Lemarchand, Audrey Thiebaut, Jérôme Parcq, et al.. Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death. Cell Death and Differentiation, Nature Publishing Group, 2017, 24 (9), pp.1518-1529. ⟨10.1038/cdd.2017.35⟩. ⟨inserm-01586769⟩
  • Alain Bruhat, Cédric Chaveroux, Valérie Carraro, Céline Jousse, Julien Averous, et al.. Réguler l’expression d’un transgène thérapeutique par un régime alimentaire carencé en un acide aminé indispensable. médecine/sciences, EDP Sciences, 2017, 33 (2), pp.136-139. ⟨10.1051/medsci/20173302007⟩. ⟨hal-02952253⟩
  • Florent Mesclon, Sarah Lambert-Langlais, Valérie Carraro, Laurent Parry, Isabelle Hainault, et al.. Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells. Oncotarget, Impact journals, 2017, 8 (16), pp.27440-27453. ⟨10.18632/oncotarget.15828⟩. ⟨hal-02952250⟩
  • Alain Bruhat, Pierre Fafournoux. The CCAAT/enhancer-binding protein–ATF response elements-luciferase mouse model, an innovative tool to monitor the integrated stress response pathway in vivo. Current Opinion in Clinical Nutrition and Metabolic Care, Lippincott, Williams & Wilkins, 2017, 20 (3), pp.175-180. ⟨10.1097/MCO.0000000000000359⟩. ⟨hal-01595543⟩
  • Florent Mesclon, Sarah Lambert-Langlais, Valerie Carraro, Laurent Parry, Isabelle Hainault, et al.. Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells. Oncotarget, Impact journals, 2017, 8 (16), pp.27440-27453. ⟨10.18632/oncotarget.15828⟩. ⟨hal-01594828⟩
  • Cédric Chaveroux, Carmen Sarcinelli, Virginie Barbet, Sofiane Belfeki, Audrey Barthelaix, et al.. Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway. Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep27278⟩. ⟨hal-02379652⟩
  • Julien Averous, Sarah Lambert-Langlais, Florent Mesclon, Valerie Carraro, Laurent Parry, et al.. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. Scientific Reports, Nature Publishing Group, 2016, 6, pp.27698. ⟨10.1038/srep27698⟩. ⟨hal-01438154⟩
  • Daniel Klionsky, Kotb Ko, Akihisa Abe, Md Joynal Jo, Hagai Abeliovich, et al.. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, Taylor & Francis, 2016, 12 (1), pp.1-222. ⟨10.1080/15548627.2015.1100356⟩. ⟨hal-01921322⟩
  • Alexis Bretin, Jessica Carrière, Guillaume Dalmasso, Agnes Bergougnoux, Wafa B'Chir, et al.. Activation of the EIF2AK4-EIF2A/eIF2 alpha-ATF4 pathway triggers autophagy response to crohn disease-associated adherent-invasive escherichia coli infection. Autophagy, Taylor & Francis, 2016, 12 (5), pp.770-783. ⟨10.1080/15548627.2016.1156823⟩. ⟨hal-02640052⟩
  • Cédric Chaveroux, Carmen Sarcinelli, Virginie Barbet, Sofiane Belfeki, Audray Barthelaix, et al.. Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway. Scientific Reports, Nature Publishing Group, 2016, 6, ⟨10.1038/srep27278⟩. ⟨hal-01595359⟩
  • Yuki Muranishi, Laurent Parry, Julien Averous, Anne Terrisse, Anne-Catherine Maurin, et al.. Method for collecting mouse milk without exogenous oxytocin stimulation. Biotechniques, Eaton Publishing, 2016, 60 (1), ⟨10.2144/000114373⟩. ⟨hal-02952379⟩
  • Cédric Chaveroux, Alain Bruhat, Valérie Carraro, Céline Jousse, Julien Averous, et al.. Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids. Nature Biotechnology, Nature Publishing Group, 2016, 34 (7), pp.746-751. ⟨10.1038/nbt.3582⟩. ⟨hal-02952372⟩
  • Cedric Chaveroux, Alain Bruhat, Valerie Carraro, Celine Jousse, Julien Averous, et al.. Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids. Nature Biotechnology, Nature Publishing Group, 2016, 34, pp.746-751. ⟨10.1038/nbt.3582⟩. ⟨hal-01594469⟩
  • Julien Averous, Sarah Lambert-Langlais, Florent Mesclon, Valérie Carraro, Laurent Parry, et al.. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep27698⟩. ⟨hal-02952365⟩
  • Yuki Muranishi, Laurent Parry, Julien Averous, Anne Terrisse, Anne-Catherine Maurin, et al.. Method for collecting mouse milk without exogenous oxytocin stimulation. Biotechniques, Eaton Publishing, 2016, 60 (1), pp.47-49. ⟨10.2144/000114373⟩. ⟨hal-01274509⟩
  • C. Chaveroux, V. Carraro, L. Canaple, J. Averous, A.-C. Maurin, et al.. In vivo imaging of the spatiotemporal activity of the eIF2 -ATF4 signaling pathway: Insights into stress and related disorders. Science Signaling, American Association for the Advancement of Science, 2015, 8 (374), pp.rs5-rs5. ⟨10.1126/scisignal.aaa0549⟩. ⟨hal-02459218⟩
  • Alain Bruhat, Celine Jousse, Valerie Carraro, Anne-Catherine Maurin, Cedric Chaveroux, et al.. L’activation de la voie eIF2α-ATF4, une réponse adaptative au stress cellulaire. médecine/sciences, EDP Sciences, 2015, 31 (12), pp.1057-1060. ⟨10.1051/medsci/20153112002⟩. ⟨hal-01595102⟩
  • Pierre Fafournoux, Julien Averous, Alain Bruhat, Valerie Carraro, Celine Jousse, et al.. Adaptation to the availability of essential amino-acids: role of GCN2/eIF2α/ATF4 pathway. Biologie Aujourd'hui, EDP sciences, 2015, 209 (4), pp.317-23. ⟨10.1051/jbio/2016005⟩. ⟨hal-01519158⟩
  • Céline Jousse, Yuki Muranishi, Laurent Parry, Christophe Montaurier, Patrick Even, et al.. Perinatal Protein Malnutrition Affects Mitochondrial Function in Adult and Results in a Resistance to High Fat Diet-Induced Obesity. PLoS ONE, Public Library of Science, 2014, 9 (8), pp.e104896. ⟨10.1371/journal.pone.0104896⟩. ⟨hal-01365546⟩
  • Wafa B'Chir, Cedric Chaveroux, Valerie Carraro, Julien Averous, Anne-Catherine Maurin, et al.. Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation. Cellular Signalling, Elsevier, 2014, 26 (7), pp.1385 - 1391. ⟨10.1016/j.cellsig.2014.03.009⟩. ⟨hal-02638190⟩
  • Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol, Xavier Brenachot, Laurent Parry, et al.. Hypothalamic eIF2 alpha signaling regulates food intake. Cell Reports, Elsevier Inc, 2014, 6 (3), pp.438-444. ⟨10.1016/j.celrep.2014.01.006⟩. ⟨hal-02635326⟩
  • Julien Averous, Sarah Lambert-Langlais, Valerie Carraro, Ophélie Gourbeyre, Laurent Parry, et al.. Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids. Cellular Signalling, Elsevier, 2014, 26 (9), pp.1918-1927. ⟨10.1016/j.cellsig.2014.04.019⟩. ⟨hal-02631139⟩
  • Wafa B'Chir, Anne-Catherine Maurin, Valerie Carraro, Julien Averous, Celine Jousse, et al.. The eIF2 alpha/ATF4 pathway is essential for stress-induced autophagy gene expression. Nucleic Acids Research, Oxford University Press, 2013, 41 (16), pp.7683 - 7699. ⟨10.1093/nar/gkt563⟩. ⟨hal-01056786⟩
  • Anne-Catherine Maurin, Cedric Chaveroux, Sarah Langlais, Valerie Carraro, Celine Jousse, et al.. The amino acid sensor GCN2 biases macronutrient selection during aging. European Journal of Nutrition, Springer Verlag, 2012, 51 (1), pp.119 - 126. ⟨10.1007/s00394-011-0205-4⟩. ⟨hal-02645818⟩
  • Hayet Ait Ghezala, Béatrice Jolles, Samia Salhi, Katia Castrillo, Wassila Carpentier, et al.. Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFs. Nucleic Acids Research, Oxford University Press, 2012, 40 (19), pp.9557 - 9570. ⟨10.1093/nar/gks762⟩. ⟨hal-01544180⟩
  • Cedric Chaveroux, Sarah Lambert-Langlais, Laurent Parry, Valerie Carraro, Celine Jousse, et al.. Identification of GCN2 as new redox regulator for oxidative stress prevention in vivo. Biochemical and Biophysical Research Communications, Elsevier, 2011, 415 (1), pp.120 - 124. ⟨10.1016/j.bbrc.2011.10.027⟩. ⟨hal-02645943⟩
  • Julien Averous, S. Lambert-Langlais, Y. Cherasse, Valerie Carraro, Laurent Parry, et al.. Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway. Biochemical and Biophysical Research Communications, Elsevier, 2011, 413 (1), pp.24 - 29. ⟨10.1016/j.bbrc.2011.08.028⟩. ⟨hal-02650318⟩
  • Céline Jousse, Laurent Parry, Sarah Lambert‐langlais, Anne-Catherine Maurin, Julien Averous, et al.. Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome. FASEB Journal, Federation of American Society of Experimental Biology, 2011, 25 (9), pp.3271-3278. ⟨10.1096/fj.11-181792⟩. ⟨hal-02460410⟩
  • Valerie Carraro, Anne-Catherine Maurin, Sarah Lambert-Langlais, Julien Averous, Cedric Chaveroux, et al.. Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2 alpha/ATF4 Pathway. PLoS ONE, Public Library of Science, 2010, 5 (12), ⟨10.1371/journal.pone.0015716⟩. ⟨hal-02660079⟩
  • Christiane Deval, Cédric Chaveroux, Anne-Catherine Maurin, Yoan Cherasse, Laurent Parry, et al.. Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways. FEBS Journal, Wiley, 2009, 276 (3), pp.707-718. ⟨10.1111/j.1742-4658.2008.06818.x⟩. ⟨hal-02666432⟩
  • Stella Palii, C.E. Kays, Christiane Deval, Alain Bruhat, Pierre Fafournoux, et al.. Specificity of amino acid regulated gene expression: Analysis of genes subjected to either complete or single amino acid deprivation. Amino Acids, Springer Verlag, 2009, 37 (1), pp.79-88. ⟨10.1007/s00726-008-0199-2⟩. ⟨hal-02667613⟩
  • Alain Bruhat, Yoan Chérasse, Cédric Chaveroux, Anne-Catherine Maurin, Celine Jousse, et al.. Amino acids as regulators of gene expression in mammals: Molecular mechanisms. Prostaglandins, Leukotrienes and Essential Fatty Acids, Elsevier, 2009, 35 (3), pp.249-257. ⟨10.1002/biof.40⟩. ⟨hal-02664128⟩
  • Christiane Deval, Jeremie Talvas, Cédric Chaveroux, Anne-Catherine Maurin, Sylvie Mordier, et al.. Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes. Biochimie, Elsevier, 2008, 90 (11-12), pp.1716-1721. ⟨10.1016/j.biochi.2008.07.004⟩. ⟨hal-02665914⟩
  • Yoan Cherasse, Cédric Chaveroux, Celine Jousse, Anne-Catherine Maurin, Valerie Carraro, et al.. Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP. FEBS Letters, Wiley, 2008, 582 (10), pp.1537-1541. ⟨10.1016/j.febslet.2008.03.050⟩. ⟨hal-02656794⟩
  • Celine Jousse, Christiane Deval, Anne-Catherine Maurin, Laurent Parry, Yoan Cherasse, et al.. TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (21), pp.15851-15861. ⟨10.1074/jbc.M611723200⟩. ⟨hal-02663945⟩
  • Alain Bruhat, Yoan Cherasse, Anne-Catherine Maurin, Wolfgang Breitwieser, Laurent Parry, et al.. ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation. Nucleic Acids Research, Oxford University Press, 2007, 35 (4), pp.1312-1321. ⟨10.1093/nar/gkm038⟩. ⟨hal-02658676⟩
  • Yoan Cherasse, Anne-Catherine Maurin, Cédric Chaveroux, Celine Jousse, Valerie Carraro, et al.. The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. Nucleic Acids Research, Oxford University Press, 2007, 35 (17), pp.5954-5965. ⟨10.1093/nar/gkm642⟩. ⟨hal-02658408⟩
  • Anne-Catherine Maurin, Celine Jousse, Julien Averous, Laurent Parry, Alain Bruhat, et al.. The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metabolism, Elsevier, 2005, 1 (4), pp.273-277. ⟨10.1016/j.cmet.2005.03.004⟩. ⟨hal-02454718⟩
  • Julien Averous, Anne-Catherine Maurin, Alain Bruhat, Celine Jousse, Celine Arliguie, et al.. Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR. FEBS Letters, Wiley, 2005, 579 (12), pp.2609-2614. ⟨10.1016/j.febslet.2005.03.077⟩. ⟨hal-02682908⟩
  • Anne-Catherine Maurin, Celine Jousse, Julien Averous, Laurent Parry, Alain Bruhat, et al.. The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metabolism, Elsevier, 2005, 1 (4), pp.273-277. ⟨hal-02677489⟩
  • Anne-Catherine Maurin, Celine Jousse, Michelle Balage, Julien Averous, Laurent Parry, et al.. La kinase GCN2 régule le comportement alimentaire des omnivores afin de maintenir l’homéostasie des acides aminés. médecine/sciences, EDP Sciences, 2005, 21 (10), pp.799-801. ⟨hal-02681321⟩
  • C. Jousse, Julien Averous, Alain Bruhat, Valérie Carraro, Sylvie Mordier, et al.. Amino acids as regulators of gene expression : Molecular mechanisms. Biochemical and Biophysical Research Communications, Elsevier, 2004, 313 (2), pp.447-452. ⟨hal-02679439⟩
  • Julien Averous, Alain Bruhat, Valerie Carraro, Celine Jousse, Gerald Thiel, et al.. Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (7), pp.5288-5297. ⟨10.1074/jbc.M311862200⟩. ⟨hal-02683570⟩
  • Julien Averous, Alain Bruhat, Sylvie Mordier, Pierre Fafournoux. Recent advances in the understanding of amino acid regulation of gene expression. Journal of Nutrition, American Society for Nutrition, 2003, 133 (6S), pp.2040S-2045S. ⟨hal-02673076⟩
  • Dominique Dardevet, I. Rieu, Pierre Fafournoux, Claire Sornet, Lydie Combaret, et al.. Leucine : A key amino acid in ageing-associated sarcopeniau?. Nutrition Research Reviews, Cambridge University Press (CUP), 2003, 16 (1), pp.61-70. ⟨hal-02676366⟩
  • Alain Bruhat, Julien Averous, Valerie Carraro, Can Zhong, Andreas M. Reimold, et al.. Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2002, 277 (50), pp.48107-48114. ⟨10.1074/jbc.M206149200⟩. ⟨hal-02683499⟩
  • C. Jousse, Alain Bruhat. Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR. Nucleic Acids Research, Oxford University Press, 2001, 29 (21), pp.4341-4351. ⟨10.1093/nar/29.21.4341⟩. ⟨hal-02940973⟩
  • Céline Jousse, Alain Bruhat, Marc Ferrara, Pierre Fafournoux. Evidence for Multiple Signaling Pathways in the Regulation of Gene Expression by Amino Acids in Human Cell Lines. Journal of Nutrition, American Society for Nutrition, 2000, 130 (6), pp.1555-1560. ⟨10.1093/jn/130.6.1555⟩. ⟨hal-02941622⟩
  • C. Jousse, Alain Bruhat, Marc Ferrara, Pierre Fafournoux. Evidence for multiple signaling pathways in the regulation of gene expression by amino acids in human cell lines. Journal of Nutrition, American Society for Nutrition, 2000, 130, pp.1555-1560. ⟨hal-02691090⟩
  • Pierre Fafournoux, Alain Bruhat, C. Jousse. Amino acid regulation of gene expression. Biochemical Journal, Portland Press, 2000, 351, 12 p. ⟨hal-02684190⟩
  • Alain Bruhat, Valérie Carraro, Andreas Reimold, Marc Ferrara, Pierre Fafournoux. Amino Acids Control Mammalian Gene Transcription: Activating Transcription Factor 2 Is Essential for the Amino Acid Responsiveness of the CHOP Promoter. Molecular and Cellular Biology, American Society for Microbiology, 2000, 20 (19), pp.7192-7204. ⟨10.1128/mcb.20.19.7192-7204.2000⟩. ⟨hal-02941593⟩
  • C. Jousse, Alain Bruhat, H.P. Harding, Marc Ferrara, D. Ron, et al.. Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response. FEBS Letters, Wiley, 1999, 448, pp.211-216. ⟨hal-02691123⟩
  • C. Jousse, Alain Bruhat, Pierre Fafournoux. Amino acid regulation of gene expression. Current Opinion in Clinical Nutrition and Metabolic Care, Lippincott, Williams & Wilkins, 1999, 2, pp.297-301. ⟨hal-02684376⟩
  • Alain Bruhat, C. Jousse, Pierre Fafournoux. Amino acid limitation regulates gene expression. Proceedings of the Nutrition Society, Cambridge University Press (CUP), 1999, 58, 8 p. ⟨hal-02684379⟩
  • Céline Jousse, Alain Bruhat, Marc Ferrara, Pierre Fafournoux. Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression. Biochemical Journal, Portland Press, 1998, 334 (1), pp.147-153. ⟨10.1042/bj3340147⟩. ⟨hal-02941605⟩
  • C. Jousse, Alain Bruhat, Marc Ferrara, Pierre Fafournoux. Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression. Biochemical Journal, Portland Press, 1998, 334, pp.147-153. ⟨hal-02695981⟩
  • Alain Bruhat, Celine Jousse, Xiao-Zhong Wang, David Ron, Marc Ferrara, et al.. Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1997, 272 (28), pp.17588-17593. ⟨10.1074/jbc.272.28.17588⟩. ⟨hal-02695708⟩

Conference papers10 documents

  • Anne-Catherine Maurin, Wafa B'Chir, Laurent Parry, Valerie Carraro, Florent Mesclon, et al.. The GCN2 kinase activates early events of autophagy. 8. Proteasome & Autophagy, Institut National de Recherche Agronomique (INRA). UMR Unité de Nutrition Humaine (1019).; Centre de Recherche en Nutrition Humaine (CRNH). FRA., Apr 2018, Clermont-Ferrand, France. 90 p. ⟨hal-01786043⟩
  • Alain Bruhat. Le sensing par GCN2 : la souris CARE-LUC, un outil pour visualiser l’activation de la voie GCN2-eIF2a-ATF4. JFN 2018, Journées Francophones de Nutrition, Nov 2018, Nice, France. ⟨hal-01937086⟩
  • Jérémy Tournayre, Laurent Parry, Anne-Catherine Maurin, Julien Averous, Alain Bruhat, et al.. Identification de marques épigénétiques marqueurs de prédisposition aux maladies métaboliques. JOBIM 2018 Journées Ouvertes Biologie, Informatique et Mathématiques, Jul 2018, Marseille, France. ⟨hal-01930383⟩
  • Pierre Fafournoux, Julien Averous, Alain Bruhat, Valerie Carraro, Celine Jousse, et al.. Mécanismes d’adaptation à la disponibilité en acides aminés indispensables : rôles de la voie GCN2/eIF2/ATF4. Société de Biologie, Société de Biologie. FRA., Dec 2015, Paris, France. ⟨hal-02796515⟩
  • Florent Mesclon, Sarah Langlais, Valerie Carraro, Laurent Parry, Cedric Chaveroux, et al.. Identification des mécanismes moléculaires impliqués dans la résistance des cellules à une carence en acides aminés. 2emes Assises Inter-Régionales De Nutrition et Métabolisme, Institut National de Recherche Agronomique (INRA). UMR Unité de Nutrition Humaine (1019).; Laboratoire de recherche en Cardiovasculaire, Métabolisme, Diabétologie et Nutrition (CarMeN). Lyon, FRA.; Université Joseph Fourier (Grenoble 1) (UJF). Grenoble, FRA.; Centre de Recherche en Nutrition Humaine (CRNH). FRA.; Centre de Recherche en Nutrition Humaine (CRNH). FRA., Nov 2015, Saint Galmier, France, France. ⟨hal-01237880⟩
  • Pierre Fafournoux, Julien Averous, Alain Bruhat, Valerie Carraro, Celine Jousse, et al.. Amino acid sensig: The EIF2A signaling in health and disease. 1. Congress of Physiology and Integrative Biologie and 84. Congress of French Physiological Society (SFP), Société de Physiologie. Vieillevigne, FRA., May 2015, Strasbourg, France. 92 p., ⟨10.1111/apha.12520⟩. ⟨hal-02742614⟩
  • Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol-Desmet, Xavier Brenachot, Laurent Parry, et al.. Hypothalamic eIF2 alpha signaling regulates food intake. Assises du département Alimh, Jan 2014, Arêches, France. n.p. ⟨hal-01065490⟩
  • Celine Jousse, Julien Averous, Anne-Catherine Maurin, Yoan Cherasse, Christiane Deval, et al.. Régulation de l'expression des gènes par les acides aminés, aspects in vitro et in vivo. Journée Scientifique du CNRH D'Auvergne, Apr 2004, Theix, France. ⟨hal-02760814⟩
  • Julien Averous, Alain Bruhat, Valérie Carraro, C. Jousse, Pierre Fafournoux. Les facteurs de transcription ATF2 et ATF4 sont impliqués dans la régulation du gène chop par la carence en acides aminés. 5. Réunion, Jun 2003, Clermont-Ferrand, France. ⟨hal-02763975⟩
  • Julien Averous, Alain Bruhat, Sylvie Mordier, Pierre Fafournoux. Recent advances in the understanding of amino acid regulation of gene expression. 2. Workshop on the Assessment of Adequate Intake of Dietary Amino Acids, Oct 2002, Honolulu, United States. ⟨hal-02828538⟩

Poster communications10 documents

  • Julien Averous, Sarah Lambert-Langlais, Florent Mesclon, Valerie Carraro, Laurent Parry, et al.. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. 1.edition Target of Rapamycin science club in France, le "TOR de France", May 2018, Nice, France. 2018. ⟨hal-01811435⟩
  • Alain Bruhat, Pierre Fafournoux. Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids. ESGCT XXV Anniversary Congress, Oct 2017, Berlin, Germany. 2017, ⟨10.1038/nbt.3582⟩. ⟨hal-02737715⟩
  • Anne-Catherine Maurin, Wafa B'Chir, Vanessa Reinhardt, Laurent Parry, Valerie Carraro, et al.. The GCN2 kinase is required for activating autophagy in response to indispensable amino acid deficiencies. 7. Proteasomes & Autophagy Workshop, Apr 2016, Clermont-Ferrand, France. 320 p., 2016, 7th Proteasomes & Autophagy Workshop. ⟨hal-01305347⟩
  • Alexis Bretin, Jessica Carrière, Guillaume Dalmasso, Agnes Bergougnoux, Wafa B'Chir, et al.. Activation of the EIF2AK4-EIF2A/eIF2 alpha-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive escherichia coli infection. 7. Proteasomes and Autophagy Workshop, Apr 2016, clermont-ferrand, France. 320 p., 2016, 7th Proteasomes and Autophagy Workshop. ⟨hal-02740425⟩
  • Florent Mesclon, Sarah Langlais, Valerie Carraro, Laurent Parry, Cedric Chaveroux, et al.. Identification of molecular mechanisms involved in cancer cell resistance to amino acid deprivation. Cancer and Metabolism conference, ABCAM 2015, Sep 2015, Cambridge, United Kingdom. 2015. ⟨hal-02739369⟩
  • A. Bretin, J. Carrière, Marion Dalmasso, N. Barnich, A. Bergougnoux, et al.. Activation of the GCN2/eIF2alpha/ATF4 signaling pathway triggers autophagy response to infection with Crohn's disease-associated adherent-invasive Escherichia coli. 10. Congress of ECCO. Inflammatory Bowel Diseases, Feb 2015, Barcelone, Spain. Journal of Crohn's and Colitis, 9, 2015, 10th Congress of ECCO. Inflammatory Bowel Diseases. ⟨hal-02740431⟩
  • Alain Bruhat, Cedric Chaveroux, Valerie Carraro, Julien Averous, Celine Jousse, et al.. Génération d’un modèle de souris transgénique pour visualiser en temps réel l’activation de la voie eIF2α/ATF4 lors d’un stress nutritionnel. Assises du Département Alimh, Jan 2014, Arêches, France. 2014, Assises du Département Alimh. ⟨hal-01190022⟩
  • Cedric Chaveroux, Alain Bruhat, Valerie Carraro, Julien Averous, Celine Jousse, et al.. Development and optimization of a new gene regulation system controlled by nutrition applicable for gene therapy. Congrès de la Société Française de Thérapie Cellulaire et Génique (SFTCG), Mar 2014, Toulouse, France. 2014. ⟨hal-02740006⟩
  • Wafa B'Chir, Anne-Catherine Maurin, Julien Averous, Celine Jousse, Yuki Muranishi, et al.. The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression. EMBO Conference, Autophagy: Molecular Mechanisms, Physiology and Pathology, May 2013, Hurtigruten, Norway. 2013. ⟨hal-02748854⟩
  • Thuy Thi Thu Nguyen, Jessica Carrière, Guillaume Dalmasso, Anne-Catherine Maurin, Alain Bruhat, et al.. The GCN2/eIF2α/ATF4 signaling pathway is necessary for autophagy response to infection with Crohn’s disease-associated adherent-invasive Escherichia coli. 6. Journée scientifique du CNRH Auvergne, Nov 2013, Clermont - Ferrand, France. 2013, 6ème Journée scientifique du CNRH Auvergne. ⟨hal-02750413⟩

Book sections3 documents

  • Julien Averous, Celine Jousse, Anne-Catherine Maurin, Alain Bruhat, Pierre Fafournoux. Adaptation to Amino Acid Availability: Role of GCN2 in the Regulation of Physiological Functions and in Pathological Disorders. The molecular nutrition of amino acids and proteins, Academic Press, 368 p., 2016, 9780128021675. ⟨hal-02799663⟩
  • Julien Averous, Sarah Langlais, Cedric Chaveroux, Laurent Parry, Valerie Carraro, et al.. Cellular adaptation to amino acid availability: mechanisms involved in the regulation of gene expression. Amino acids in human nutrition and health, CABI Publishing, pp.14, 2012, 978-1-84593-798-0. ⟨hal-02805890⟩
  • Sylvie Mordier, Alain Bruhat, Julien Averous, Pierre Fafournoux. Cellular adaptation to amino acid availability : Mechanisms involved in the regulation of gene expression and protein metabolism. Cell and molecular response to stress. Volume 3 : Sensing, signalling and cell adaptation, 3, Elsevier, 2002, 0-444-51147-4. ⟨hal-02826696⟩

Directions of work or proceedings1 document

  • Alain Bruhat, Cedric Chaveroux, Valerie Carraro, Celine Jousse, Julien Averous, et al.. Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids. European Society of Gene and Cell Therapy (ESCGT) Congress, Oct 2017, Berlin, Germany. 28 (12), Mary Ann Liebert, pp.A61-A61, 2017, Human Gene Therapy, ⟨10.1089/hum.2017.29055.abstracts⟩. ⟨hal-02786230⟩

Patents2 documents

  • Pierre Fafournoux, Alain Bruhat, Celine Jousse, Anne-Catherine Maurin, Julien Averous. Inducible expression cassette, and uses thereof. Patent n° : US 2014/0322184 A1. 2014. ⟨hal-02792534⟩
  • Pierre Fafournoux, Alain Bruhat, Celine Jousse, Anne-Catherine Maurin, Julien Averous. Cassette d’expression inductible et ses utilisations. N° de brevet: EP2776568 A1. 2011. ⟨hal-02809468⟩