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48

Abderrahim MICHRAFY


 

PERSONAL SUMMARY

In 1988, I obtained my Ph.D. in applied mathematics from the University of Bordeaux, France. Then, I joined the CNRS (French Council Research Centre) in 1989 as Research Engineer in modeling and computation science. Since, I successively worked for three French laboratories in chemical and mechanical fields (LRGP, Nancy, ICA- Albi and RAPSODEE, Albi). In 2011, I successfully defended my HDR (Habilitation à Diriger des Recherches).

My research is focused on mechanical material behaviours (continuum solid mechanics and particulate solids) and on finite element modeling (FEM) of forming process. Currently in the lab. of Particulate Solids and Processes of Ecole des Mines (RAPSODEE Albi, France), I develop research work on die and roll-compaction processes for pharmaceutical and mineral applications. I was involved in different projects (regional, national and European) and in a patent filing. I supervised PhD, postdoctoral, M. Sc students and gave training courses in high graduate schools and Universities in FEM modeling and Pharmaceutical Processes. A part of publication concerned damage modeling of composite material and hot rolling process, but the most scientific production focused on powder technology and dry granulation/compaction process with more forty publications and book chapters.

 

MAIN INDUSTRIAL PROJECTS AND TRAINING PROGRAMMES

  • 2018-2021: Project funded by an Industrial Partner and the local Government of the region Midi-Pyrenees, on the damage modelling during the compaction of energetic material
  • 2017- 2020: Project funded by the Ecole des Mines and CNRS on the thermo-mechanical modeling aspects in compaction process of sensitive pharmaceutical powders to the temperature
  • 2013 - 2016: Partner of the European Project IPROCOM (the development of in silico process models for roll compaction - FP7-PEOPLE-ITN), which consists of 10 full partners and 15 ESR & ER
  • 2013 - 2015: Partner of an innovative project funded by a pharmaceutical company, a food company and the regional government. A new product for both health and nutrition was developed as part of this project, which resulted in a patent filing.
  • 2012 - 2013: Partner of industrial project with Lafarge Company on milling process modeling of mineral products
  • 2006 - 2008: Project IMCAT (Innovative Materials for CO2 Capture by Adsorption Technology) funded by the National Research Agency (ANR) and coordinated by Air-Liquid Company. Three laboratories (RAPSODEE, ICMUB, ENSCP) were implied in this research program to develop MOFs (Metal-Organic Frameworks) materials for catalysis applications.
  • 2005 - 2006: Collaborative project with the Chair of Process Engineering TU München–Weihenstephan funded by “le centre inter-universitaire Franco-Bavarois”. This project concerned “Numerical modeling of rolling compaction process” and gave opportunity to PhD students to have secondment in France and Germany (Dr. Stefan Haas & Dr. Daniela Herold from the lab. of Prof. K. Sommer). 

 

AREAS OF EXPERTISE

Elastic plastic behaviour Modeling; Computer Science; Finite Element Methods; Die & Roll Compaction process; hot rolling process; Material Characterizations


Journal articles25 documents

  • Hossam Zawbaa, Serena Schiano, Lucia Perez-Gandarillas, Crina Grosan, Abderrahim Michrafy, et al.. Computational intelligence modelling of pharmaceutical tabletting processes using bio-inspired optimization algorithms. Advanced Powder Technology, Elsevier, 2018, 29 (12), p.2966-2977. ⟨10.1016/j.apt.2018.11.008⟩. ⟨hal-01944490⟩
  • Alon Mazor, Luca Orefice, Abderrahim Michrafy, Alain de Ryck, Johannes Khinast. A combined DEM & FEM approach for modelling roll compaction process. Powder Technology, Elsevier, 2018, 337, pp.3-16. ⟨10.1016/j.powtec.2017.04.053⟩. ⟨hal-01848201⟩
  • Lucia Perez-Gandarillas, Alon Mazor, Olivier Lecoq, Abderrahim Michrafy. Compaction properties of dry granulated powders based on Drucker–Prager Cap model. Powder Technology, Elsevier, 2018, 337, pp.43-50. ⟨10.1016/j.powtec.2017.12.057⟩. ⟨hal-01700665⟩
  • Mohammad Hassan Khalid, Pezhman Kazemi, Lucia Perez-Gandarillas, Abderrahim Michrafy, Jakub Szlek, et al.. Computational intelligence models to predict porosity of tablets using minimum features. Drug Design, Development and Therapy, Dove Medical Press, 2017, 11, pp.193-202. ⟨10.2147/DDDT.S119432⟩. ⟨hal-01619260⟩
  • Lucia Perez-Gandarillas, Ana Perez-Gago, Alon Mazor, Peter Kleinebudde, Olivier Lecoq, et al.. Effect of roll-compaction and milling conditions on granules and tablet properties. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2016, 106 (SI), pp.38-49. ⟨10.1016/j.ejpb.2016.05.020⟩. ⟨hal-01609014⟩
  • Vincent Velay, Abderrahim Michrafy. An analytical model for the prediction of hot roll temperatures in a hot rolling process. Materials Science and Engineering Technology / Materialwissenschaft und Werkstofftechnik, Wiley-VCH Verlag, 2016, 47 (12), p. 1202-1215. ⟨10.1002/mawe.201600554⟩. ⟨hal-01609107⟩
  • Alon Mazor, Lucia Perez-Gandarillas, Alain de Ryck, Abderrahim Michrafy. Effect of roll compactor sealing system designs: A finite element analysis. Powder Technology, Elsevier, 2016, 289, pp.21-30. ⟨10.1016/j.powtec.2015.11.039⟩. ⟨hal-01609015⟩
  • Vivien Esnault, Abderrahim Michrafy, Daniel Heitzmann, Mohamed Michrafy, Driss Oulahna. Processing fine powders by roll press. Powder Technology, Elsevier, 2015, 270 (Part B, SI), p. 484-489. ⟨10.1016/j.powtec.2014.07.046⟩. ⟨hal-01609219⟩
  • Chuan-Yu Wu, Abderrahim Michrafy, Aleksander Mendyk, Satoru Watano. Pharmaceutical Particle Technology. Powder Technology, Elsevier, 2015, 285 (SI), p. 1. ⟨10.1016/j.powtec.2015.09.014⟩. ⟨hal-01611003⟩
  • Lucia Perez-Gandarillas, Alon Mazor, David Souriou, Olivier Lecoq, Abderrahim Michrafy. Compaction behaviour of dry granulated binary mixtures. Powder Technology, Elsevier, 2015, 285, pp.62-67. ⟨10.1016/j.powtec.2015.05.003⟩. ⟨hal-01611086⟩
  • Vivien Esnault, D. Heitzmann, M. Michrafy, Driss Oulahna, Abderrahim Michrafy. Numerical simulation of roll compaction of aerated powders. Chemical Engineering Science, Elsevier, 2013, 104, pp.717-726. ⟨10.1016/j.ces.2013.09.031⟩. ⟨hal-00936759⟩
  • Moulay S. Kadiri, Abderrahim Michrafy. The effect of punch's shape on die compaction of pharmaceutical powders. Powder Technology, Elsevier, 2013, 239, pp.467-477. ⟨10.1016/j.powtec.2013.02.022⟩. ⟨hal-01688099⟩
  • Abderrahim Michrafy, Harona Diarra, John A. Dodds, M. Michrafy, Luc Penazzi. Analysis of strain stress state in roller compaction process. Powder Technology, Elsevier, 2011, 208 (2, SI), pp.417-422. ⟨10.1016/j.powtec.2010.08.037⟩. ⟨hal-01680752⟩
  • Abderrahim Michrafy, El. Diarra, John A. Dodds, M. Michrafy. Experimental and numerical analyses of homogeneity over strip width in roll compaction. Powder Technology, Elsevier, 2011, 206 (1-2, SI), pp.154-160. ⟨10.1016/j.powtec.2010.04.030⟩. ⟨hal-01680751⟩
  • Abderrahim Michrafy, Harona Diarra, John A. Dodds. Compaction behavior of binary mixtures. Powder Technology, Elsevier, 2009, 190 (1-2), pp.146-151. ⟨10.1016/j.powtec.2008.04.066⟩. ⟨hal-01680756⟩
  • Z. Hatim, Abderrahim Michrafy, M. Elassfouri, F. Abida. Stoichiometry and particle morphology effects on the aptitude to compaction of apatitic structure powders. Powder Technology, Elsevier, 2009, 190 (1-2, SI), pp.210-214. ⟨10.1016/j.powtec.2008.04.040⟩. ⟨hal-01718078⟩
  • Gilles Dour, Farid Medjedoub, Gabriel Diaconu, Denis Girardin, Abderrahim Michrafy, et al.. Size effect in transient thermal fatigue testing and thermo-mechanical screening of coatings. International Journal of Microstructure and Materials Properties, Inderscience, 2008, 3 (2-3), pp.311-325. ⟨10.1504/IJMMP.2008.018737⟩. ⟨hal-01847804⟩
  • Abderrahim Michrafy, M. Michrafy, Moulay S. Kadiri, John A. Dodds. Predictions of tensile strength of binary tablets using linear and power law mixing rules. International Journal of Pharmaceutics, Elsevier, 2007, 333 (1-2), pp.118-126. ⟨10.1016/j.ijpharm.2006.10.008⟩. ⟨hal-01680765⟩
  • Abderrahim Michrafy, S Haas, Moulay S. Kadiri, K Sommer, John A. Dodds. The effects of ambient temperature on the compaction of pharmaceutical powders. Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, SAGE Publications, 2006, 220 (E1), pp.1-6. ⟨10.1243/095440805X73636⟩. ⟨hal-01680767⟩
  • Moulay S. Kadiri, Abderrahim Michrafy, John A. Dodds. Pharmaceutical powders compaction: Experimental and numerical analysis of the density distribution. Powder Technology, Elsevier, 2005, 157 (1-3), pp.176-182. ⟨10.1016/j.powtec.2005.05.025⟩. ⟨hal-01829580⟩
  • Abderrahim Michrafy, John A. Dodds, Moulay S. Kadiri. Wall friction in the compaction of pharmaceutical powders: measurement and effect on the density distribution. Powder Technology, Elsevier, 2004, 148 (1), pp.53-55. ⟨10.1016/j.powtec.2004.09.021⟩. ⟨hal-01680773⟩
  • Abderrahim Michrafy, Moulay S. Kadiri, John A. Dodds. Wall friction and its effects on the density distribution in the compaction of pharmaceutical excipients. Chemical Engineering Research and Design, Elsevier, 2003, 81 (A8), pp.946-952. ⟨10.1205/026387603322482185⟩. ⟨hal-01680780⟩
  • Abderrahim Michrafy, D Ringenbacher, P Tchoreloff. Modelling the compaction behaviour of powders: application to pharmaceutical powders. Powder Technology, Elsevier, 2002, 127 (3), pp.257-266. ⟨10.1016/S0032-5910(02)00119-5⟩. ⟨hal-01718086⟩
  • S Broucaret, Abderrahim Michrafy, Gilles Dour. Heat transfer and thermo-mechanical stresses in a gravity casting die - Influence of process parameters. Journal of Materials Processing Technology, Elsevier, 2001, 110 (2), pp.211-217. ⟨10.1016/S0924-0136(00)00881-5⟩. ⟨hal-01718087⟩
  • Gilles Dour, A. Broucaret, Alexis Oudin, Abderrahim Michrafy, Farhad Rezai-Aria. Rôle du poteyage et de la température initiale du moule sur les sollicitations thermomécaniques des moules permanents de fonderie. Matériaux & Techniques, EDP Sciences, 2000, p.45-50. ⟨10.1051/mattech/200088120045s⟩. ⟨hal-01847830⟩

Conference papers22 documents

  • Vivien Esnault, Mohamed Michrafy, Driss Oulahna, Abderrahim Michrafy. The flow of fine powders during roll compaction. SFGP 2013 -14ème Congrès français en génie des procédés, Oct 2013, Lyon, France. Art.2013120501-8 p. ⟨hal-01769829⟩
  • Vivien Esnault, Daniel Heitzmann, Driss Oulahna, Alain de Ryck, Abderrahim Michrafy. Modeling of aerated powder consolidation in roller compaction process. PARTEC 2013 -International Congress on Particle Technology, Apr 2013, Nürnberg, Germany. 4 p. ⟨hal-01741803⟩
  • Vivien Esnault, Daniel Heitzmann, Mohamed Michrafy, Driss Oulahna, Abderrahim Michrafy. Understanding effects of air pressure in fine powders during roll compaction process. 6th International granulation workshop, Jun 2013, Sheffield, United Kingdom. 12 p. ⟨hal-01741804⟩
  • Abderrahim Michrafy, Driss Oulahna, Olivier Lecoq. Analyse expérimentale de délaminage de comprimés bi-couches. STP 2012 -7ème Colloque Science et Technologie des Poudres, Jul 2012, Toulouse, France. 8 p. ⟨hal-01768690⟩
  • Driss Oulahna, Romain Collet, Abderrahim Michrafy, Alain de Ryck. Behavior of wetted insoluble granular materials : effect of particle shape. 5th International granulation workshop, Jun 2011, Lausanne, Switzerland. 14 p. ⟨hal-01757375⟩
  • Atef Dhaouadi, Abderrahim Michrafy, Driss Oulahna. Caractérisation mécanique de granulés d'alumine en compression uniaxiale. Matériaux 2010, Oct 2010, Nantes, France. 8 p. ⟨hal-01768697⟩
  • Abderrahim Michrafy, Toma Mihai Chitu, Driss Oulahna. Modification of granular behavior by roller compaction. WCPT6 2010 -World Congress on Particle Technology, Apr 2010, Nuremberg, Germany. 4 p. ⟨hal-01753259⟩
  • Toma Mihai Chitu, Driss Oulahna, Mehrdji Hemati, Abderrahim Michrafy. Effect of process parameters and binder nature on the mechanical properties of granules obtained in a laboratory high shear mixer. WCPT6 2010 -World Congress on Particle Technology, Apr 2010, Nuremberg, Germany. 4 p. ⟨hal-01757389⟩
  • Abderrahim Michrafy, Harona Diarra, John A. Dodds, Mohamed Michrafy, Luc Penazzi. Analysis of strain stress state in roller compaction process. STPMF 2009 -Colloque Science et Technologie des Poudres & Matériaux Frittés, May 2009, Montpellier, France. 12 p. ⟨hal-01768700⟩
  • Harona Diarra, Abderrahim Michrafy, John A. Dodds, Mohamed Michrafy. Experimental and numerical analysis of homogenenity over strip width in roll compaction. 9th International symposium on agglomeration, Jun 2009, Sheffield, United Kingdom. 14 p. ⟨hal-01757394⟩
  • Harona Diarra, Abderrahim Michrafy, John A. Dodds, Denis Marty. Three-dimensional FEM analysis of rolling compaction of pharmaceutical excipients. PSA 2008 -Particulate Systems Analysis 2008, Sep 2008, Stratford-upon-Avon, United Kingdom. 5 p. ⟨hal-01753288⟩
  • Harona Diarra, Abderrahim Michrafy, John A. Dodds. Analyse de la pression d'alimentation dans le procédé de compactage à rouleaux. 11ème congrès de la société française de génie des procédés, Oct 2007, Saint Etienne, France. 7 p. ⟨hal-01768715⟩
  • Harona Diarra, Abderrahim Michrafy, John A. Dodds. Procédé de compactage à rouleaux : analyse de la pression d'alimentation. STP 2007 -Science et technologie des poudres, May 2007, Albi, France. 6 p. ⟨hal-01769868⟩
  • Zineb Hatim, Abderrahim Michrafy, Mostafa Elassfouri, F. Abida. Stoichiometry and particles morphology effects on the aptitude to the compaction of apatitic structure powders. STP 2007 -Science et technologie des poudres, May 2007, Albi, France. 6 p. ⟨hal-01769870⟩
  • Abderrahim Michrafy, Moulay S. Kadiri, John A. Dodds. Resistance de comprimés binaires concaves : effet de courbure et proportions de mélange. STP 2007 -Science et technologie des poudres, May 2007, Albi, France. 6 p. ⟨hal-01769874⟩
  • Abderrahim Michrafy, John A. Dodds, Moulay S. Kadiri. Modelling of pharmaceutical powder compaction and its sensitivity to powder properties and tablet curvature. 11ème congrès de la société française de génie des procédés, Oct 2007, Saint Etienne, France. 7 p. ⟨hal-01769875⟩
  • Gilles Dour, Farid Medjedoub, Gabriel Diaconu, Denis Girardin, Abderrahim Michrafy, et al.. Size effect in transient thermal fatigue testing and thermo-mechanical screening of coatings. TOOL 06 -7th International tooling conference, May 2006, Torino, Italy. p.555-562. ⟨hal-01781645⟩
  • Abderrahim Michrafy, S. Haas, Moulay S. Kadiri, John A. Dodds. Effects of die and punches temperature on the compaction of pharmaceutical powders. 8th International Symposium on Agglomeration, Mar 2005, Bangkok, Thailand. p.311-316. ⟨hal-01782619⟩
  • Gabriel Diaconu, Tahar Loulou, Abderrahim Michrafy, Farhad Rezai-Aria, Denis Girardin, et al.. A normalized approach to optimize the coating/substrate couples with regards to thermal stresses : conditions for thermo-mechanical screening. 6th International Congress on Thermal Stresses, May 2005, Vienna, Austria. p.111-114. ⟨hal-01782621⟩
  • Moulay S. Kadiri, Abderrahim Michrafy, John A. Dodds. Compression des poudres pharmaceutiques : analyse expérimentale et numérique de la distribution de densité. 4ème Colloque Science et technologie des poudres -Récents progrès en génie des procédés, May 2004, Compiègne, France. 9 p. ⟨hal-01780099⟩
  • Abderrahim Michrafy, John A. Dodds, Moulay S. Kadiri. Wall friction in the compaction of pharmaceutical powders : measurement and effect on the density distribution. APHYS-2003 international conference, Oct 2003, Badajov, Spain. 5 p. ⟨hal-01781688⟩
  • S. Broucaret, Abderrahim Michrafy, Bruno Ladevie, Gilles Dour. Heat transfer in a gravity casting die influence of process parameters. Modeling of casting, welding and advanced solidification processes IX, Aug 2000, Aachen, Germany. p.705-712. ⟨hal-01796860⟩

Book sections1 document

  • Abderrahim Michrafy, A. Zavaliangos, John Cunningham. Dry granulation process modeling. Predictive Modeling of Pharmaceutical Unit Operations (chap. 4), Elsevier, p.71-97, 2017, Woodhead publishing series in biomedicine ; 87, 978-0-08-100154-7. ⟨10.1016/B978-0-08-100154-7.00004-1⟩. ⟨hal-01693629⟩