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The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies
Timothée Blin
,
Christelle Parent
,
Gabrielle Pichon
,
Antoine Guillon
,
Youenn Jouan
Article dans une revue
hal-04484465v1
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Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects
Thomas Sécher
,
Elsa Bodier-Montagutelli
,
Christelle Parent
,
Laura Bouvart
,
Mélanie Cortes
Article dans une revue
hal-03687448v1
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Therapeutic antibodies – natural and pathological barriers and strategies to overcome them
Yara Al Ojaimi
,
Timothée Blin
,
Juliette Lamamy
,
Matthieu Gracia
,
Aubin Pitiot
Article dans une revue
hal-03531953v1
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Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
Claire Mackowiak
,
Tiffany Marchiol
,
Hana Cipcic Paljetak
,
Louis Fauconnier
,
Jennifer Palomo
Article dans une revue
hal-03429701v1
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Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives
Alexie Mayor
,
Adélaïde Chesnay
,
Guillaume Desoubeaux
,
David Ternant
,
Nathalie Heuzé-Vourc'H
Article dans une revue
hal-03485350v1
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Immune Checkpoint and Anti-Angiogenic Antibodies for the Treatment of Non-Small Cell Lung Cancer in the European Union and United States
Marion Ferreira
,
Thomas Secher
,
Nathalie Heuzé-Vourc'H
,
Karen Reckamp
Article dans une revue
hal-03382451v1
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Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
Claire Mackowiak
,
Tiffany Marchiol
,
Hana Cipcic Paljetak
,
Louis Fauconnier
,
Jennifer Palomo
Article dans une revue
hal-03258180v1
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MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands
Marion Pavlovic
,
Christelle Gross
,
Chahinaize Chili
,
Thomas Secher
,
Emmanuel Treiner
Article dans une revue
hal-03154944v1
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Inhalation of Immuno-Therapeutics/- Prophylactics to Fight Respiratory Tract Infections: An Appropriate Drug at the Right Place!
Thomas Secher
,
Alexie Mayor
,
Nathalie Heuzé-Vourc'H
Article dans une revue
hal-02439828v1
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The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure
Nadine Waldschmitt
,
Sho Kitamoto
,
Thomas Secher
,
Vassiliki Zacharioudaki
,
Olivier Boulard
Article dans une revue
hal-02126570v1
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Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917
Clémence Massip
,
Priscilla Branchu
,
Nadège Bossuet-Greif
,
Camille V Chagneau
,
Déborah Gaillard
Article dans une revue
inserm-02320208v1
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In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration
Thomas Secher
,
Emilie Dalonneau
,
Marion Ferreira
,
Christelle Parent
,
Nicolas Azzopardi
Article dans une revue
hal-02179896v1
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Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics
A. Guillon
,
Thomas Secher
,
L.A. Dailey
,
L. Vecellio
,
M. de Monte
Article dans une revue
hal-02439838v1
|
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Therapeutic antibodies: A new era in the treatment of respiratory diseases?
Thomas Secher
,
L. Guilleminault
,
K. Reckamp
,
I. Amanam
,
L. Plantier
Article dans une revue
hal-02439820v1
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The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice
Thomas Secher
,
Isabelle Maillet
,
Claire Mackowiak
,
Jessica Le Bérichel
,
Amandine Philippeau
Article dans une revue
hal-02126575v1
|
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Mu and delta opioid receptor knockout mice show increased colonic sensitivity
David Reiss
,
R.A. Ceredig
,
Thomas Secher
,
J. Boué
,
Frédérick Barreau
Article dans une revue
hal-01607491v1
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The food contaminant deoxynivalenol exacerbates the genotoxicity of gut microbiota
Delphine Payros
,
Ulrich Dobrindt
,
Patricia Martin-Bizon
,
Thomas Secher
,
Ana-Paula Loureiro-Bracarense
Article dans une revue
hal-01608529v1
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Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction
Thomas Secher
,
Sahar Kassem
,
Mehdi Benamar
,
Isabelle Bernard-Cadenat
,
Michèle Boury
Article dans une revue
hal-02624001v1
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DNA Inversion Regulates Outer Membrane Vesicle Production in Bacteroides fragilis
Haruyuki Nakayama-Imaohji
,
Katsuhiko Hirota
,
Hisashi Yamasaki
,
Saori Yoneda
,
Hirofumi Nariya
Article dans une revue
hal-02632202v1
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Early settlers: which E. coli strains do you not want at birth?
Thomas Secher
,
Camille Brehin
,
Eric Oswald
Article dans une revue
hal-01602829v1
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Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin
Thomas Secher
,
Delphine Payros
,
Camille Brehin
,
Michèle Boury
,
Claude Watrin
Article dans une revue
hal-02634629v1
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Retrograde trafficking inhibitor of Shiga toxins reduces morbidity and mortality of mice infected with enterohemorrhagic Escherichia coli
Thomas Secher
,
Ayaka Shima
,
Karen Hinsinger
,
Jean Christophe Cintrat
,
Ludger Johannes
Article dans une revue
hal-02640796v1
|
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Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis
Delphine Payros
,
Thomas Secher
,
Michèle Boury
,
Camille Brehin
,
Sandrine Ménard
Article dans une revue
hal-01859355v2
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IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice
Rodrigo Guabiraba
,
Anne-Gaëlle Besnard
,
Gustavo Batista Menezes
,
Thomas Secher
,
M. S. Jabir
Article dans une revue
hal-02633989v1
|
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Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells
Thomas Secher
,
Ascel Samba Louaka
,
Eric Oswald
,
Jean-Philippe Nougayrède
Article dans une revue
hal-02646496v1
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Dysbiosis, a new medical concept
Sylvain Normand
,
Thomas Secher
,
Mathias Chamaillard
Article dans une revue
hal-02180092v1
|
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Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice
Bérengère Villeret
,
Lea Brault
,
Aurélie Couturier-Maillard
,
Pauline Robinet
,
Virginie Vasseur
American journal of Clinical and Experimental Immunology, 2013, 2 (1), pp.107-116
Article dans une revue
hal-02651056v1
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NOD2 prevents emergence of disease-predisposing microbiota
Thomas Secher
,
Sylvain Normand
,
Mathias Chamaillard
Article dans une revue
hal-02180087v1
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NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.
Aurélie Couturier-Maillard
,
Thomas Secher
,
Ateequr Rehman
,
Sylvain Normand
,
Adèle de Arcangelis
Article dans une revue
hal-00944194v1
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Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity
Maïwenn Olier
,
Ingrid Marcq
,
Christel Cartier
,
Thomas Secher
,
Ulrich Dobrindt
Article dans une revue
hal-02935516v1
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Local and remote tissue injury upon intestinal ischemia and reperfusion depends on the TLR/MyD88 signaling pathway.
Tatiana Victoni
,
Fernando Rodrigues Coelho
,
Alexandre Learth Soares
,
Andressa de Freitas
,
Thomas Secher
Article dans une revue
hal-00591521v1
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Remote control of intestinal tumorigenesis by innate immunity.
Thomas Secher
,
Olivier Gaillot
,
Bernhard Ryffel
,
Mathias Chamaillard
Article dans une revue
hal-00591500v1
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Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation.
Kevin N Couper
,
Tom Barnes
,
Julius C R Hafalla
,
Valery Combes
,
Bernhard Ryffel
Article dans une revue
hal-00591502v1
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Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis.
Thomas Secher
,
Virginie Vasseur
,
Didier Marc Poisson
,
Jane A Mitchell
,
Fernando Q Cunha
Article dans une revue
hal-00404907v1
|
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Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.
Laure Janot
,
Jean-Claude Sirard
,
Thomas Secher
,
Nicolas Noulin
,
Lizette Fick
Article dans une revue
inserm-00385299v1
|
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Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.
R. Dessein
,
M. Gironella
,
Clémentine Vignal
,
L. Peyrin-Biroulet
,
H. Sokol
Article dans une revue
hal-00404858v1
|
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IL-17 receptor signaling is required to control polymicrobial sepsis.
Andressa Freitas
,
José C Alves-Filho
,
Tatiana Victoni
,
Thomas Secher
,
Henrique P Lemos
Article dans une revue
hal-00404905v1
|
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CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection.
Laure Janot
,
Thomas Secher
,
David Torres
,
Isabelle Maillet
,
Josef Pfeilschifter
Article dans une revue
hal-00318570v1
|
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Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection.
Jonathan Zalevsky
,
Thomas Secher
,
Sergei A Ezhevsky
,
Laure Janot
,
Paul M Steed
Journal of Immunology, 2007, 179 (3), pp.1872-83
Article dans une revue
hal-00318488v1
|
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Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury.
Dieudonnée Togbe
,
Silvia Schnyder-Candrian
,
Bruno Schnyder
,
Emilie Doz
,
Nicolas Noulin
Article dans une revue
hal-00318537v1
|