Jean-Claude Sirard

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jean-claude-sirard
ResearcherId : B-5932-2011
IdRef : 124317901
0000-0001-9854-4652
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	Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells Christine van Linge , Katina Hulme , Hessel Peters-Sengers , Jean-Claude Sirard , Wil Goessens International Journal of Molecular Sciences, 2023, 25 (1), pp.309. ⟨10.3390/ijms25010309⟩ Article dans une revue hal-04462460v1
	Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function. Melanie Mondeme , Yasmine Zeroual , Daphne Soulard , Benjamin Hennart , Delphine Beury Journal of Leukocyte Biology, 2023, Journal of Leukocyte Biology, pp.qiad125. ⟨10.1093/jleuko/qiad125⟩ Article dans une revue hal-04474406v1
	Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence Vikrant Minhas , Arnau Domenech , Dimitra Synefiaridou , Daniel Straume , Max Brendel PLoS Biology, 2023, 21 (1), pp.e3001990. ⟨10.1371/journal.pbio.3001990⟩ Article dans une revue hal-04462466v1
	Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity Mélanie Mondemé , Christophe Carnoy , Jean-Claude Sirard , Christelle Faveeuw Infection and Immunity, 2023, 91 (2), pp.e00503-22. ⟨10.1128/iai.00503-22⟩ Article dans une revue hal-04238526v1
	Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq Liselot Dewachter , Julien Dénéréaz , Xue Liu , Vincent de Bakker , Charlotte Costa eLife, 2022, 11, ⟨10.7554/eLife.75607⟩ Article dans une revue hal-04462473v1
	TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium Isabelle Fleurot , Raquel López-Gálvez , Pascal Barbry , Antoine Guillon , Mustapha Si-Tahar Journal of Cystic Fibrosis, 2022, 21 (2), pp.e117-e121. ⟨10.1016/j.jcf.2021.08.002⟩ Article dans une revue hal-03556846v1
	The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia Robin Michelet , Moreno Ursino , Sandrine Boulet , Sebastian Franck , Fiordiligie Casilag Pharmaceutics, 2021, 13 (5), pp.601. ⟨10.3390/pharmaceutics13050601⟩ Article dans une revue hal-03215662v1
	mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin I. Ramirez-Moral , X. Yu , J. M. Butler , M. van Weeghel , N. A. Otto Mucosal Immunology, 2021, 14 (3), pp.594-604. ⟨10.1038/s41385-021-00377-8⟩ Article dans une revue hal-03258194v1
	The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced infection in cigarette smoke-exposed mice Magdiel Pérez-Cruz , Bachirou Koné , Rémi Porte , Christophe Carnoy , Julien Tabareau PLoS ONE, 2021, 16 (3), ⟨10.1371/journal.pone.0236216⟩ Article dans une revue hal-03258191v1
	A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice Sebastian Franck , Robin Michelet , Fiordiligie Casilag , Jean Claude Sirard , Sebastian G. Wicha Pharmaceutics, 2021, 13 (4), pp.1-12. ⟨10.3390/pharmaceutics13040469⟩ Article dans une revue hal-03258185v1
	Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa Raquel López-Gálvez , Isabelle Fleurot , Pablo Chamero , Sascha Trapp , Olivier Michel American Journal of Respiratory Cell and Molecular Biology, 2021, 65 (4), pp.378-389. ⟨10.1165/rcmb.2021-0125OC⟩ Article dans une revue hal-03258174v1
	The Biosynthetic Monophosphoryl Lipid A Enhances the Therapeutic Outcome of Antibiotic Therapy in Pneumococcal Pneumonia. Fiordiligie Casilag , Laura Matarazzo , Sebastian Franck , Martin Figeac , Robin Michelet ACS Infectious Diseases, 2021, Online ahead of print. ⟨10.1021/acsinfecdis.1c00176⟩ Article dans une revue inserm-03288018v1
	Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling Claire Mackowiak , Tiffany Marchiol , Hana Cipcic Paljetak , Louis Fauconnier , Jennifer Palomo ImmunoHorizons , 2021, 5 (5), pp.273 - 283. ⟨10.4049/immunohorizons.2000095⟩ Article dans une revue hal-03429701v1
	Live attenuated Bordetella pertussis vaccine candidate BPZE1 transiently protects against lethal pneumococcal disease in mice Thomas Belcher , Hana Kammoun , Loïc Coutte , Anne-Sophie Debrie , Nathalie Mielcarek Vaccine, inPress, ⟨10.1016/j.vaccine.2021.01.025⟩ Article dans une revue hal-03372774v1
	Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling Claire Mackowiak , Tiffany Marchiol , Hana Cipcic Paljetak , Louis Fauconnier , Jennifer Palomo ImmunoHorizons , 2021, 5 (5), pp.273-283. ⟨10.4049/immunohorizons.2000095⟩ Article dans une revue hal-03258180v1
	Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection Wanhai Qin , Xanthe Brands , Cornelis Van’t Veer , Alex F. de Vos , Jean Claude Sirard PLoS Pathogens, 2021, 17 (4), ⟨10.1371/journal.ppat.1009491⟩ Article dans une revue hal-03258188v1
	The GM-CSF released by airway epithelial cells orchestrates the mucosal adjuvant activity of flagellin Aneesh Vijayan , Laurye van Maele , Delphine Fougeron , Delphine Cayet , Jean Claude Sirard Journal of Immunology, 2020, pp.ji2000746 Article dans une revue inserm-02957765v1
	Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae Robin A. Sorg , Clement Gallay , Laurye van Maele , Jean Claude Sirard , Jan-Willem Veening Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (44), pp.27608-27619. ⟨10.1073/pnas.1920015117⟩ Article dans une revue hal-03258211v1
	Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4 Anne-Sophie Debrie , Nathalie Mielcarek , Sophie Lecher , Xavier Roux , Jean Claude Sirard Journal of Immunology, 2019, pp.ji1901102. ⟨10.4049/jimmunol.1901102⟩ Article dans une revue inserm-02398404v1
	Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir Anne-France Georgel , Delphine Cayet , Andrés Pizzorno , Manuel Rosa-Calatrava , Christophe Paget Antiviral Research, 2019, 168, pp.28-35. ⟨10.1016/j.antiviral.2019.05.002⟩ Article dans une revue inserm-02144074v1
	A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume Sebastian Franck , Tania Fuhrmann-Selter , Jan Joseph , Robin Michelet , Fiordiligie Casilag Talanta, 2019, 201, pp.253-258. ⟨10.1016/j.talanta.2019.03.098⟩ Article dans une revue inserm-02144087v1
	Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants Marina Elizabeth Biedma , Delphine Cayet , Julien Tabareau , Andrés Rossi , Karolina Ivičak-Kocjan Vaccine, 2019, 37 (4), pp.652-663. ⟨10.1016/j.vaccine.2018.12.009⟩ Article dans une revue inserm-02078833v1
	Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia Laura Matarazzo , Fiordiligie Casilag , Rémi Porte , Frederic Wallet , Delphine Cayet Frontiers in Immunology, 2019, 10, pp.723. ⟨10.3389/fimmu.2019.00723⟩ Article dans une revue inserm-02144080v1
	Toll‐like receptor 4 signaling in hematopoietic‐lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01 Laurye van Maele , Delphine Fougeron , Delphine Cayet , Aurélie Chalon , Diego Piccioli European Journal of Immunology, 2019, 49 (12), pp.2134-2145. ⟨10.1002/eji.201948234⟩ Article dans une revue inserm-02398403v1
	Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection Ranin Beshara , Valentin Sencio , Daphnée Soulard , Adeline Barthélémy , Josette Fontaine PLoS Pathogens, 2018, 14 (10), pp.e1007360. ⟨10.1371/journal.ppat.1007360⟩ Article dans une revue inserm-02078841v1
	Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation Fabien Bastaert , Saadé Kheir , Vinciane Saint-Criq , Bérengère Villeret , Pham My-Chan Dang Frontiers in Immunology, 2018, 9, pp.1675. ⟨10.3389/fimmu.2018.01675⟩ Article dans une revue inserm-02078851v1
	Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae Khalil Farhat , Gwennaëlle Bodart , Chantal Charlet-Renard , Christophe Desmet , Michel Moutschen Frontiers in Immunology, 2018, 9, pp.2175. ⟨10.3389/fimmu.2018.02175⟩ Article dans une revue inserm-02078849v1
	Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages. Catherine Sabatel , Coraline Radermecker , Laurence Fievez , Genevieve Paulissen , Svetoslav Chakarov Immunity, 2017, 46 (3), pp.457-473. ⟨10.1016/j.immuni.2017.02.016⟩ Article dans une revue inserm-01529380v1
	Compartmentalized Antimicrobial Defenses in Response to Flagellin Aneesh Vijayan , Martin Rumbo , Christophe Carnoy , Jean-Claude Sirard Trends in Microbiology, 2017, 9, pp.143 - 153. ⟨10.1016/j.tim.2017.10.008⟩ Article dans une revue inserm-01671191v1
	Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22. Rémi Porte , Laurye van Maele , Natalia Muñoz-Wolf , Benoit Foligné , Laure Dumoutier Infection and Immunity, 2017, 85 (2), pp.e00806-16. ⟨10.1128/IAI.00806-16⟩ Article dans une revue inserm-01529315v1
	Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner. Agustina Errea , Delphine Cayet , Philippe Marchetti , Cong Tang , Jerome Kluza PLoS ONE, 2016, 11 (11), pp.e0163694. ⟨10.1371/journal.pone.0163694⟩ Article dans une revue inserm-01529298v1
	Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion. Natalia Muñoz-Wolf , Analía Rial , Delphine Fougeron , Julien Tabareau , Jean-Claude Sirard Future Microbiology, 2016, 11 (9), pp.1167-77. ⟨10.2217/fmb-2016-0045⟩ Article dans une revue inserm-01529275v1
	Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model. Carolina Iraporda , David E Romanin , Ana A Bengoa , Agustina J Errea , Delphine Cayet Frontiers in Immunology, 2016, 7, pp.651. ⟨10.3389/fimmu.2016.00651⟩ Article dans une revue inserm-01529366v1
	Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells. Agathe Goubard , Caroline Loïez , Jun Abe , Caroline Fichel , Stéphanie Herwegh Infection and Immunity, 2015, 83 (5), pp.2053-64. ⟨10.1128/IAI.02339-14⟩ Article dans une revue inserm-01182906v1
	Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract Delphine Fougeron , Laurye van Maele , Pascal Songhet , Delphine Cayet , David Hot Vaccine, 2015, 33 (29), pp.3331-41. ⟨10.1016/j.vaccine.2015.05.022⟩ Article dans une revue inserm-01182907v1
	A toll-like receptor 5 agonist improves the efficacy of antibiotics in the treatment of primary and influenza-associated pneumococcal mouse infections. Rémi Porte , Delphine Fougeron , Natalia Muñoz-Wolf , Julien Tabareau , Anne-France Georgel Antimicrobial Agents and Chemotherapy, 2015, 59 (10), pp.6064-6072. ⟨10.1128/AAC.01210-15⟩ Article dans une revue inserm-01182908v1
	Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5 Magdalena Matusiak , Nina van Opdenbosch , Lieselotte Vande Walle , Jean-Claude Sirard , Thirumala-Devi Kanneganti Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (5), pp.6. ⟨10.1073/pnas.1417945112⟩ Article dans une revue inserm-01182904v1
	Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection. Stoyan Ivanov , Joelle Renneson , Josette Fontaine , Adeline Barthelemy , Christophe Paget Journal of Virology, 2013, 87 (12), pp.6911-24. ⟨10.1128/JVI.02943-12⟩ Article dans une revue inserm-00926618v1
	Airway structural cells regulate TLR5-mediated mucosal adjuvant activity. Laurye van Maele , Delphine Fougeron , Laure Janot , Arnaud Didierlaurent , Delphine Cayet Mucosal Immunology, 2013, epub ahead of print. ⟨10.1038/mi.2013.66⟩ Article dans une revue inserm-00925663v1
	In vivo germination of Bacillus anthracis spores during murine cutaneous infection. Jean-Philippe Corre , Alejandro Piris-Gimenez , Marie Moya-Nilges , Gregory Jouvion , Agnes Fouet Journal of Infectious Diseases, 2013, 207 (3), pp.450-7. ⟨10.1093/infdis/jis686⟩ Article dans une revue inserm-00926617v1
	The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon. Maria L. Knudsen , Daniel X. Johansson , Linda Kostic , Eva K. L. Nordström , Karin Tegerstedt PLoS ONE, 2013, 8 (6), pp.e65964. ⟨10.1371/journal.pone.0065964⟩ Article dans une revue inserm-00925649v1
	Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection. Griselda Moreno , Agustina Errea , Laurye van Maele , Roy Roberts , Hélène Léger Microbes and Infection, 2013, 15 (10-11), pp.708-18. ⟨10.1016/j.micinf.2013.06.010⟩ Article dans une revue inserm-00925669v1
	NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. Boas Felmy , Pascal Songhet , Emma Marie Caroline Slack , Andreas J. Müller , Marcus Kremer PLoS ONE, 2013, 8 (10), pp.e77204. ⟨10.1371/journal.pone.0077204⟩ Article dans une revue inserm-00925654v1
	Transgenic mouse model harboring the transcriptional fusion ccl20-luciferase as a novel reporter of pro-inflammatory response. Martina Crispo , Laurye van Maele , Julien Tabareau , Delphine Cayet , Agustina Errea PLoS ONE, 2013, 8 (11), pp.e78447. ⟨10.1371/journal.pone.0078447⟩ Article dans une revue inserm-00925644v1
	Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity. Juan M. Marqués , Analía Rial , Natalia Muñoz , Francois-Xavier Pellay , Laurye van Maele Immunobiology, 2012, 217 (4), pp.420-9. ⟨10.1016/j.imbio.2011.10.012⟩ Article dans une revue inserm-00926614v1
	Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide. Stoyan Ivanov , Josette Fontaine , Christophe Paget , Elodie Macho Fernandez , Laurye van Maele Journal of Infectious Diseases, 2012, 206 (5), pp.723-34. ⟨10.1093/infdis/jis413⟩ Article dans une revue inserm-00926616v1
	IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality. Laure Dumoutier , Magali de Heusch , Ciriana Orabona , Naoko Satoh-Takayama , Gerard Eberl European Journal of Immunology, 2011, 41 (4), pp.1075-85. ⟨10.1002/eji.201040878⟩ Article dans une revue inserm-00926611v1
	The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea. Kathrin Endt , Bärbel Stecher , Samuel Chaffron , Emma Slack , Nicolas Tchitchek PLoS Pathogens, 2010, 6 (9), pp.e1001097. ⟨10.1371/journal.ppat.1001097⟩ Article dans une revue inserm-00520162v1
	IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium. Pascal Songhet , Manja Barthel , Till A Röhn , Laurye van Maele , Delphine Cayet PLoS ONE, 2010, 5 (11), pp.e13804. ⟨10.1371/journal.pone.0013804⟩ Article dans une revue inserm-00926613v1
	TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. Laurye van Maele , Christophe Carnoy , Delphine Cayet , Pascal Songhet , Laure Dumoutier Journal of Immunology, 2010, 185 (2), pp.1177-85. ⟨10.4049/jimmunol.1000115⟩ Article dans une revue inserm-00495564v1
	Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection. Natalia Munoz , Laurye van Maele , Juan Marqués , Analia Rial , Jean-Claude Sirard Infection and Immunity, 2010, 78 (10), pp.4226-4233. ⟨10.1128/IAI.00224-10⟩ Article dans une revue inserm-00520159v1
	The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells Céline Beauvillain , Francesca Meloni , Jean-Claude Sirard , Simon Blanchard , Ulrich Jarry Journal of Hepatology, 2010, 52 (5), pp.644-51. ⟨10.1016/j.jhep.2009.11.031⟩ Article dans une revue inserm-00926610v1
	Toll-like receptor 5- and lymphotoxin beta receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics. Jean-Claude Sirard , Arnaud Didierlaurent , Delphine Cayet , Frédéric Sierro , Martin Rumbo Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1789 (5), pp.386-94. ⟨10.1016/j.bbagrm.2009.03.001⟩ Article dans une revue inserm-00385296v1
	Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin. Laure Janot , Jean-Claude Sirard , Thomas Secher , Nicolas Noulin , Lizette Fick European Journal of Immunology, 2009, 39 (6), pp.1587-96. ⟨10.1002/eji.200838907⟩ Article dans une revue inserm-00385299v1
	Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. Arnaud Didierlaurent , John Goulding , Seema Patel , Robert Snelgrove , Lionel Low Journal of Experimental Medicine, 2008, 205 (2), pp.323-9. ⟨10.1084/jem.20070891⟩ Article dans une revue inserm-00227540v1
	Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity. Clément Nempont , Delphine Cayet , Martin Rumbo , Coralie Bompard , Vincent Villeret Journal of Immunology, 2008, 181 (3), pp.2036-2043. ⟨10.4049/jimmunol.181.3.2036⟩ Article dans une revue inserm-00309796v1
	A key role of dendritic cells in probiotic functionality. Benoit Foligne , Georgia Zoumpopoulou , Joelle Dewulf , Amena Ben Younes , Fabrice Chareyre PLoS ONE, 2007, 2 (3), pp.e313. ⟨10.1371/journal.pone.0000313⟩ Article dans une revue inserm-00177781v1
	Nod-like receptors: cytosolic watchdogs for immunity against pathogens. Jean-Claude Sirard , Cécile Vignal , Rodrigue Dessein , Mathias Chamaillard PLoS Pathogens, 2007, 3 (12), pp.e152. ⟨10.1371/journal.ppat.0030152⟩ Article dans une revue inserm-00223906v1
	Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells. Aizhen Guo , Melissa A. Lasaro , Jean-Claude Sirard , Jean-Pierre Kraehenbuhl , Dieter M. Schifferli Microbiology, 2007, 153 (Pt 4), pp.1059-69. ⟨10.1099/mic.0.2006/000331-0⟩ Article dans une revue inserm-00177727v1
	Pathogen-specific TLR signaling in mucosa: mutual contribution of microbial TLR agonists and virulence factors. Jean-Claude Sirard , Mariela Bayardo , Arnaud Didierlaurent European Journal of Immunology, 2006, 36, pp.260-3. ⟨10.1002/eji.200535777⟩ Article dans une revue inserm-00000042v1
	Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium. Rachel A. Luu , Komal Gurnani , Renu Dudani , Rajagopal Kammara , Henk van Faassen Journal of Immunology, 2006, 177 (3), pp.1516-1525. ⟨10.4049/jimmunol.177.3.1516⟩ Article dans une revue inserm-00177783v1
	Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5. Martin Rumbo , Clément Nempont , Jean-Pierre Kraehenbuhl , Jean-Claude Sirard FEBS Letters, 2006, 580 (12), pp.2976-84. ⟨10.1016/j.febslet.2006.04.036⟩ Article dans une revue inserm-00071278v1
	Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Marie Le Borgne , Nathalie Etchart , Anne Goubier , Sergio A. Lira , Jean Claude Sirard Immunity, 2006, 24, pp.191-201. ⟨10.1016/j.immuni.2006.01.005⟩ Article dans une revue inserm-00000041v1
	Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Arnaud Didierlaurent , Brian Brissoni , Dominique Velin , Natalia Aebi , Aubry Tardivel Molecular and Cellular Biology, 2006, 26, pp.735-42. ⟨10.1128/MCB.26.3.735-742.2006⟩ Article dans une revue inserm-00000043v1
	Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells. Martin Rumbo , Françoise Courjault-Gautier , Frédéric Sierro , Jean-Claude Sirard , Emanuela Felley-Bosco FEBS Journal, 2005, 272 (2), pp.444-53. ⟨10.1111/j.1742-4658.2004.04484.x⟩ Article dans une revue inserm-00000045v1
	Innate and acquired plasticity of the intestinal immune system. Arnaud Didierlaurent , Michel Simonet , Jean-Claude Sirard Cellular and Molecular Life Sciences, 2005, 62 (12), pp.1285-7. ⟨10.1007/s00018-005-5032-4⟩ Article dans une revue inserm-00000044v1
	How the gut links innate and adaptive immunity. Martin Rumbo , Pascale Anderle , Arnaud Didierlaurent , Frédéric Sierro , Nathalie Debard Annals of the New York Academy of Sciences, 2004, 1029, pp.16-21. ⟨10.1196/annals.1309.003⟩ Article dans une revue inserm-00223904v1
	Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa. Hugo Cruz Ramos , Martin Rumbo , Jean-Claude Sirard Trends Microbiol, 2004, 12 (11), pp.509-17. ⟨10.1016/j.tim.2004.09.002⟩ Article dans une revue inserm-00000046v1
	Interaction of pathogenic bacteria with rabbit appendix M cells: bacterial motility is a key feature in vivo Marta Marchetti , Jean Claude Sirard , Philippe Sansonetti , Eric Pringault , Sophie Kerneis Microbes and Infection, 2004, 6 (6), pp.521-528. ⟨10.1016/j.micinf.2004.02.009⟩ Article dans une revue hal-02675770v1

Jean-Claude Sirard

Présentation

Domaines de recherche

Compétences

Publications

Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells

Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function.

Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence

Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium

The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia

mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced infection in cigarette smoke-exposed mice

A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice

Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa

The Biosynthetic Monophosphoryl Lipid A Enhances the Therapeutic Outcome of Antibiotic Therapy in Pneumococcal Pneumonia.

Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling

Live attenuated Bordetella pertussis vaccine candidate BPZE1 transiently protects against lethal pneumococcal disease in mice

Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling

Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

The GM-CSF released by airway epithelial cells orchestrates the mucosal adjuvant activity of flagellin

Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae

Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4

Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir

A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume

Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants

Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia

Toll‐like receptor 4 signaling in hematopoietic‐lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01

Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection

Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation

Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae

Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.

Compartmentalized Antimicrobial Defenses in Response to Flagellin

Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.

Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.

Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model.

Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells.

Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract

A toll-like receptor 5 agonist improves the efficacy of antibiotics in the treatment of primary and influenza-associated pneumococcal mouse infections.

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.

Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.

In vivo germination of Bacillus anthracis spores during murine cutaneous infection.

The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon.

Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection.

NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.

Transgenic mouse model harboring the transcriptional fusion ccl20-luciferase as a novel reporter of pro-inflammatory response.

Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity.

Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide.

IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality.

The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea.

IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium.

TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.

Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection.

The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells

Toll-like receptor 5- and lymphotoxin beta receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics.

Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.

Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.

Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity.

A key role of dendritic cells in probiotic functionality.

Nod-like receptors: cytosolic watchdogs for immunity against pathogens.

Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells.

Pathogen-specific TLR signaling in mucosa: mutual contribution of microbial TLR agonists and virulence factors.

Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.

Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5.

Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.

Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.

Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells.

Innate and acquired plasticity of the intestinal immune system.

How the gut links innate and adaptive immunity.

Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa.

Interaction of pathogenic bacteria with rabbit appendix M cells: bacterial motility is a key feature in vivo